国家重点基础研究发展计划(USA)

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Identification of SNPs involved in regulating a novel alternative transcript of P450 CYP6ER1 in the brown planthopper被引量：2
《Insect Science》2018年第5期726-738,共13页Zhi-Kun Liang Rui Pang Yi Dong Zhong-Xiang Sun Yan Ling Wen-Qing Zhang 
We thank Dr. Jianming Chen （Zhejiang Academy of Agri- cultural Sciences, Hangzhou, China） for providing the susceptible population and Jiaxing field-collected pop- ulation, and Dr. Ping Wang （Cornell University, USA） for his critical comments on this manuscript. This work was funded by the National Basic Research Program of China （Grant 2010CB 126200）, National Natural ScienceFoundation of China （U 1401212） and the China Postdoc- toral Science Foundation （2016M602582）.
Cytochrome P450-mediated metabolic resistance is one of the major mecha- nisms involved in insecticide resistance. Although the up-regulation of cytochrome P450 plays a vital role in insecticide metabolism, the molecu...
关键词：alternative splicing cytochrome P450 Nilaparvata lugens single nucleotidepolymorphisms （SNPs） transcription factor binding 
The molecular mechanism of SPOROCYTELESS/NOZZLE in controlling Arabidopsis ovule development被引量：10
《Cell Research》2015年第1期121-134,共14页Baoye Wei Jinzhe Zhang Changxu Pang Hao Yu Dongshu Guo Hao Jiang Mingxin Ding Zhuoyao Chen Qing Tao Hongya Gu Li-Jia Qu Genji Qin 
We thank Dr Yunde Zhao （University of California at San Diego, USA） for valuable suggestions. We thank Dr Jeff Long （University of California, Los Angeles, USA） and Dr Tomotsugu Koyama （Kyoto University, Japan） for kindly providing the seeds of tpl-1 and tcp3 tcp4 tcp5 tcp10. This work was supported by the National Key Basic Research Program of China （973- 2012CB944801）, the National Natural Science Foundation of China （31270321）, and National Transformation Science and Technology Program （2014ZX08009003-003-003）. This work was also partially supported by the 111 Project （B06001）.
Ovules are essential for plant reproduction and develop into seeds after fertilization. SPOROCYTELESS/NOZZLE （SPL/NZZ） has been known for more than 15 years as an essential factor for ovule development in Arabidopsi...
关键词：SPOROCYTELESS/NOZZLE transcriptional repressor TPL/TPR co-repressors TCP transcription factors SPOROGENESIS 
Bidirectional regulation between WDR83 and its natural antisense transcript DHPS in gastric cancer被引量：4
《Cell Research》2012年第9期1374-1389,共16页Wen-Yu Su Jiong-Tang Li Yun Cui Jie Hong Wan Du Ying-Chao Wang Yan-Wei Lin Hua Xiong Ji-Lin Wang Xuan Kong Qin-Yan Gao Li-Ping Wei Jing-Yuan Fang 
We are grateful to Dr Tim （Qing-Rong） Liu （National Institutes of Health, USA） for insightful suggestions. We thank the ENCODE Consortium, including the University of Washington ENCODE group, the transcriptome group at Affymetrix, and Cold Spring Harbor Laboratories, for providing the open-accessible transcriptome data and the labs of Michael Snyder, Mark Gerstein, and Sherman Weissman at Yale University and Peggy Farnham at University of California, Davis. This work was supported by grants from the National Basic Research Program of China （973 program; 2010CB5293 to JYF and 2007CB946904 to LPW）, the National Natural Science Foundation of China （30971330 to JYF; National Outstanding Young Investigator Award （31025014） to LPW）, the China Ministry of Science and Technology （863 Hi-Tech R＆D Program; 2007AA02ZI65 to LPW）, and the Doctor Innovation Foundation of Shanghai Jiao-Tong University School of Medicine （BXJ201117 to WYS）.
Natural antisense transcripts （NATs） exist ubiquitously in mammalian genomes and play roles in the regulation of gene expression. However, both the existence of bidirectional antisense RNA regulation and the possibi...
关键词：bidirectional regulation natural antisense transcript gastric cancer 
NOPO modulates Egr-induced JNK-independent cell death in Drosophila
《Cell Research》2012年第2期425-431,共7页Xianjue Ma Jiuhong Huang Lixia Yang Yang Yang Wenzhe Li Lei Xue 
Acknowledgments We thank Z Wang （Chinese Academy of Sciences）, L Lee （Vanderbilt University, USA）, R Wyman （Yale University, USA）, KBasler （University of Zurich, Switzerland）, M Miura （University of Tokyo, Japan）, T Igaki （Kobe University, Japan）, D Bohmann and H Jasper （University of Rochester, USA）, RK Murphey （Florida Atlantic University, USA）, Bloomington, Harvard, VDRC, Szeged, and NIG stock centers for fly stocks, M Ho （Tongji University, China） and members of Xue lab for discussion and comments. This work is supported by grants from the National Natural Science Foundation of China （30971681 and 31071294）, the National Basic Research Program of China （973 Program; 2010CB944901 and 2011CB943903）, Shanghai Pujiang Program （09PJ1409400）, the Innovation Program of Shanghai Municipal Education Commission （10ZZ27）, Program for New Century Excellent Talents in University （NCET-10-0608） and Shanghai Committee of Science and Technology （09DZ2260100） to L X.
Tumor necrosis factor （TNF） family ligands play essential roles in regulating a variety of cellular processes includ- ing proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger （Eg...
关键词：cTNF JNK NOPO CASPASE cell death 
Exogenous plant MIR168a specifically targets mammalian LDLRAPI： evidence of cross-kingdom regulation by microRNA被引量：167
《Cell Research》2012年第1期107-126,共20页Lin Zhang Dongxia Hou Xi Chen Donghai Li Lingyun Zhu Yuj ing Zhang Jing Li Zhen Bian Xiangying Liang Xing Cai Yuan Yin Cheng Wang Tianfu Zhang Dihan Zhu Dianmu Zhang Jie Xu Qun Chen Yi Ba Jing Liu Qiang Wang Jianqun Chen Jin Wang Meng Wang Qipeng Zhang Junfeng Zhang Ke Zen Chen-Yu Zhang 
We thank Dr Daniel Wu （Yale University, USA） and Dr Zheng- Gang Liu （Cancer Research Institute, NIH, USA） for critical reading of the manuscript and discussion of data. This work was supported by grants from the National Natural Science Foundation of China （90813035, 30890044, 30771036, 30772484, 30725008, 30890032, 31071232, 31000323, and 90608010）, the National Basic Research Program of China （973 Program 2006CB503909, 2007CB815701, 2007CB815703, 2007CB815705, and 2007CB815804; 863 Program 2006AA02Z177 and 2006AA10A121）, and the Natural Science Foundation of Jiangsu Province （BK2008021）.
Our previous studies have demonstrated that stable microRNAs （miRNAs） in mammalian serum and plasma are actively secreted from tissues and cells and can serve as a novel class of biomarkers for diseases, and act as ...
关键词：MICRORNA MIR168a LDLRAP1 low-density lipoprotein MICROVESICLE cross-kingdom 
TRAIL receptor mediates inflammatory cytokine release in an NF-κB-dependent manner被引量：14
《Cell Research》2009年第6期758-767,共10页Wanhu Tang Weimin Wang Yaxi Zhang Shilian Liu Yanxin Liu Dexian Zheng 
We thank Drs Hongbing Shu （Wuhan University, China）, Jiandong Li （University of Rochester Medical Center, USA）, Andrew Thorbum （University of Colorado Comprehensive Cancer Center, USA） and Andreas Strasser （The Walter and Eliza Hall Institute of Medical Research, Australia） for the generous gifts of the constructs. This work was partially supported by the National Natural Science Foundation of China （Grants 30571687 and 30721063） and the State Key Basic Research Program of China （Grant 2007CB507404）.
In the present article, we report that DR4 or DR5 overexpression dramatically activates the release of the inflammatory cytokines IL-8, TNF-α, CCL20, MIP-2 and MIP-1β in an NF-κB-dependent manner in 293T, MDA-MB-23...
关键词：TRAIL receptor INFLAMMATION CYTOKINE NF-ΚB 
A large-scale functional approach to uncover human genes and pathways in Drosophila被引量：5
《Cell Research》2008年第11期1114-1127,共14页Rong Xu Kejing Deng Yi Zhu Yue Wu Jing Ren Min Wan Shouyuan Zhao Xiaohui Wu Min Han Yuan Zhuang Tian Xu 
We are grateful to Xizhi Ma, Junnian Zhou, Tianhong Xu, Xu Liu, Xu Ding, Yang Liu, Ying Peng, Congwu Chi, Yiying Shang, Mingyao Ying, Sheng Ding, Lei Sun, Lei Tian, Huanhu Zhu, Hua Huang, Hongmei Li, and Xiaomo Wu for cDNA constructs and partial transgenic work, and Lihui Zhou （East China University of Science and Technology, China） for scanning electron microscopy. We thank Duc Nguyen （Yale University, USA） for critical reading and editing of this manuscript. This work is supported by grants from the National Natural Science Foundation of China （Grant Nos. 30030080, 39970408 and 30470840）, National Basic Research Program of China （973） （Grant No. 2006CB806700）.
We demonstrate the feasibility of performing a systematic screen for human gene functions in Drosophila by assaying for their ability to induce overexpression phenotypes. Over 1 500 transgenic fly lines corresponding ...
关键词：DROSOPHILA human gene GAL4/UAS genetic screen RPL8 insulin signaling 
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