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国家自然科学基金(81302905): 作品数：14被引量：176H指数：8; 导出分析报告; 相关作者：张爱华王喜军闫广利孙晖韩莹更多>>; 相关机构：黑龙江中医药大学更多>>; 相关期刊：《World Journal of Traditional Chinese Medicine》《中国中药杂志》《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》更多>>; 相关主题：TRADITIONAL_CHINESE_MEDICINE代谢组学中医方证药效物质基础中药血清药物化学更多>>; 相关领域：医药卫生自然科学总论更多>>

Small molecule metabolites:discovery of biomarkers and therapeutic targets被引量：15: 《Signal Transduction and Targeted Therapy》2023年第4期1684-1720,共37页Shi Qiu Ying Cai Hong Yao Chunsheng Lin Yiqiang Xie Songqi Tang Aihua Zhang; the generous support from the Program of Natural Science Foundation of State(Grant No.81973745,82104733,81302905);Talent Lift Engineering Project of China Association of TCM(QNRC2-B06);Natural Science Foundation of Heilongjiang Province(YQ2019H030)。; Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is wellrecognizedhallmarks of diseases. Metabolite signatures that have close proximity to subject...; 关键词：DIAGNOSIS THERAPEUTIC SMALL

Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine被引量：37: 《Engineering》2019年第1期60-68,共9页Ai-Hua Zhang Hui Sun Guang-Li Yan Ying Han Qi-Qi Zhao Xi-Jun Wang; grants from the Key Program of National Natural Science Foundation of China (81830110, 81430093, 81373930, 81673586, 81302905, and 81503386);the National Key Subject of Drug Innovation (2015ZX09101043-005 and 2015ZX09101043-011);the TCM State Administration Subject of Public Welfare (2015468004);the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province (UNPYSCT-2015118);the Young Talent Lift Engineering Project of China Association of Traditional Chinese Medicine (QNRC2-B06).; Evaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent nee...; 关键词：Chinmedomics SERUM pharmacochemistry of TCM EFFICACY Metabolomics SYNDROME Biomarkers Quality MARKERS

Chinmedomics:Newer Theory and Application被引量：4: 《Chinese Herbal Medicines》2016年第4期299-307,共9页Xi-jun Wang Ai-hua Zhang Hui Sun Guang-li Yan; Key Program of Natural Science Foundation of State(Grant No.90709019,81430093,81173500,81373930,81302905,81202639);National Key Subject of Drug Innovation(Grant No.2015ZX09101043-005,2015ZX09101043-011); The scientific interpretation of the effectiveness of traditional Chinese medicine（TCM） is a communication channel between Chinese medicine and modern medicine. The evaluation of TCM efficacy is an important prerequ...; 关键词：active constituents biomarkers Chinmedomics effectiveness traditional Chinese medicine

基于中医方证代谢组学的开心散干预老年痴呆症大鼠的效应物质动态分析被引量：12: 《世界科学技术-中医药现代化》2016年第10期1652-1669,共18页初航卢盛文孔玲韩莹韩金伟刘志东张爱华王喜军; 国家自然科学基金委重点项目(81430093):中药体内药效物质基础的系统分析方法学--中医方证代谢组学研究;负责人:王喜军;国家自然科学基金委青年科学基金项目(81302905):基于药物代谢组学的开心散防治老年痴呆症的物质基础及机制研究;负责人:张爱华;黑龙江省科技厅自然科学基金面上项目(H2015038):基于代谢组学策略研究开心散治疗AD的药效物质和作用机理;负责人:张爱华; 目的:本研究在开心散干预氯化铝联合D-半乳糖诱导老年痴呆症大鼠模型有效性的基础上,揭示开心散对老年痴呆症(AD)不同阶段干预作用的代谢物靶点,构建开心散体内成分与内源性生物标记物的网络关系,分析开心散对AD发展过程干预作用的效应...; 关键词：老年痴呆症开心散代谢组学中医方证代谢组学

Metabolomics Deciphering Therapeutic Effects and Mechanism of Traditional Chinese Medicines被引量：1: 《World Journal of Traditional Chinese Medicine》2016年第3期17-24,共8页Wei-Wei Ma Ai-Hua Zhang Hui Sun Xiang-Cai Meng Xi-Jun Wang; supported by grants from the Supporting Program of Outstanding Innovation of Heilongjiang University of Chinese Medicine(Grant No.2012RCQ15);Key Program of Natural Science Foundation of State(Grant No.81430093,81373930,81302905,81202639,81473584,90709019);National Key Subject of Drug Innovation(Grant No.2015ZX09101043-005,2015ZX09101043-011);TCM State Administration Subject of Public Welfare of(Grant No.2015468004);Natural Science Foundation of Heilongjiang Province of China(H2015038);University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province(UNPYSCT-2015118); Traditional Chinese medicine(TCM),an ancient medical system,has the advantages of multi-targeting and multi-ingredient preparations,and is different from modern pharmacology.However,because of the complexity of TCM an...; 关键词：Metabolomics Biomarkers METABOLITES Traditional Chinese medicine SYNDROMES

Novel chinmedomics strategy for discovering effective constituents from ShenQiWan acting on ShenYangXu syndrome被引量：15: 《Chinese Journal of Natural Medicines》2016年第8期561-581,共21页ZHOU Xiao-Hang ZHANG Ai-Hua WANG Liang TAN Yun-Long GUAN Yu HAN Ying SUN Hui WANG Xi-Jun; supported by the Key Program of Natural Science Foundation of State(Nos.81430093,81173500,81373930,81302905,81202639);National Key Subject of Drug Innovation(Nos.2015ZX09101043-005,2015ZX09101043-011);the Natural Science Foundation of Heilongjiang Province of China(H2015038);Youth Innovative Talent Program of Heilongjiang Province of China(UNPYSCT-2015118); Elucidation of the efficacy of traditional Chinese medicine(TCM) is of importance for scientists of modern medicine to understand the value of TCM clinical experience, and it is necessary to have a biological language...; 关键词：Chinmedomics ShenQiWan ShenYangXu syndrome Metabolomics Serum pharmacochemistry

中药有效性评价与药效物质基础发现被引量：11: 《世界科学技术-中医药现代化》2016年第5期719-723,共5页张爱华孙晖闫广利王喜军; 国家自然科学基金委重点项目(81430093):中药体内药效物质基础的系统分析方法学--中医方证代谢组学研究;负责人:王喜军;国家自然科学基金委面上项目(81373930):基于代谢标记物及代谢经路的生脉散防治老年性痴呆的药效物质基础及作用机制研究;负责人:王喜军;国家自然科学基金委青年基金项目(81302905):基于药物代谢组学的开心散防治老年痴呆症的物质基础及机制研究;负责人:张爱华;科学技术部"重大新药创制"国家科技重大专项(2015ZX09101043-005;2015ZX09101043-011):中药经典名方整合作用机制关键技术研究;负责人:王喜军; 中药有效性是中医药治疗优势的根本体现,而有效性的科学阐释是沟通中医学与现代医学科学的渠道,中药有效性评价是发现药效物质基础的前提。因此急需建立一种生物学语言,把中药的有效性科学地表达出来,让现代生命科学领域认识和接受中医...; 关键词：中医方证代谢组学中药血清药物化学有效性评价药效物质基础生物标记物

Pharmacokinetics Applications of Traditional Chinese Medicines: 《World Journal of Traditional Chinese Medicine》2016年第1期42-47,共6页Qiu-Ju Li Ai-Hua Zhang Hui Sun Xi-Jun Wang; supported by grants from the Key Program of Natural Science Foundation of State(Grant No.81430093,90709019,81373930,81173500,81302905,81202639);Natural Science Foundation of Heilongjiang Province of China(H2015038); Traditional Chinese medicine(TCM) has been widely used in many oriental countries for thousands of years and played an indispensable role in the prevention and treatment of diseases, especially the complicated and chr...; 关键词：Traditional Chinese medicine PHARMACOKINETICS Drug discovery Active constituents

Metabolomics and Its Potential in Drug Discovery and Development From TCM被引量：3: 《World Journal of Traditional Chinese Medicine》2015年第4期26-32,共7页Hang Chu Ai-Hua Zhang Ying Han Xi-Jun Wang; supported by grants from the Key Program of Natural Science Foundation of State(Grant No.81430093,90709019,81373930,81173500,81302905,81202639);Natural Science Foundation of Heilongjiang Province of China(H2015038); Metabolomics, an omic science in systems biology, is the comprehensive profiling of metabolic changes occurring in living systems and has been widely used in the modern research of traditional Chinese medicine(TCM). T...; 关键词：Metabolomics traditional Chinese medicine FORMULAE BIOMARKER drug discovery

UPLC-Q-TOF/MS-based metabolomic studies on the toxicity mechanisms of traditional Chinese medicine Chuanwu and the detoxification mechanisms of Gancao, Baishao, and Ganjiang被引量：23: 《Chinese Journal of Natural Medicines》2015年第9期687-698,共12页DONG Hui YAN Guang-Li HAN Ying SUN Hui ZHANG Ai-Hua LI Xian-Na WANG Xi-Jun; supported by the Key Program of National Natural Science Foundation of China(Nos.81430093,81173500,81373930,81302905,81102556,and 81202639);National Key Subject of Drug Innovation(Nos.2015ZX09101043-005 and 2015ZX09101043-011);Heilongjiang University of Chinese Medicine Scientific Research Fund Projects(No.201307);Application Technology and Development of Youth Talents Project of Harbin,China(2014RFQXJ116); Chuanwu(CW), a famous traditional Chinese medicine(TCM) from the mother roots of Aconitum carmichaelii Debx..(Ranunculaceae), has been used for the treatment of various diseases. Unfortunately, its toxicity is frequen...; 关键词：Metabolomics Aconitum Chuanwu Detoxification Compatibility

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