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高等学校学科创新引智计划(111-2-07): 作品数：16被引量：93H指数：6; 导出分析报告; 相关作者：陈依军张陆勇江振洲吴旭日王昀更多>>; 相关机构：中国药科大学教育部耶鲁大学更多>>; 相关期刊：《中国药科大学学报》《中国医药生物技术》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>; 相关主题：C-GLYCOSIDESTESTOSTERONE英文碳肝损伤更多>>; 相关领域：医药卫生理学生物学农业科学更多>>

Triptolide reduces prostate size and androgen level on testosterone-induced benign prostatic hyperplasia in Sprague Dawley rats被引量：8: 《Chinese Journal of Natural Medicines》2017年第5期341-346,共6页WANG Yu-Rong XU Yuan JIANG Zhen-Zhou ZHANG Lu-Yong WANG Tao; supported by National Natural Science Foundation of China(Nos.81173651,81320108029,and 81303301);the 2011’ Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education,“the 111 Project(111-2-07)”; Benign prostatic hyperplasia(BPH) is an age-related disease of unknown etiology, characterized by prostatic enlargement coincident with distinct alterations in tissue histology. In the present study, we investigated w...; 关键词：TRIPTOLIDE Benign prostatic hyperplasia ANDROGEN

The importance of start codon of nosM in nosiheptide production被引量：3: 《Chinese Journal of Natural Medicines》2015年第11期854-860,共7页JIANG Lei XUE Yan-Jiu LIU Wei-Ying MA Min WU Xu-Ri WANG Shu-Zhen CHEN Yi-Jun; supported by the grants from the"111"Project from the Ministry of Education of China and State Administration of Foreign Export Affairs of China(No.111-2-07);the National Key Project on Science and Technology of China(No.2012ZX09103101-030&2012ZX09201101-012);National Science Foundation of China(No.81172967);the Doctoral Fund from the Ministry of Education of China(No.20110096110011);the Science&Technology Pillar Program of Jiangsu Province(No.SBE201371217);the Priority Academic Program Development of Jiangsu Higher Education Institutions; The present study was designed to investigate the effects of start codon of nosM on the biosynthesis of nosiheptide. Target genes were amplified by overlap PCR. After homologous recombination to construct engineered s...; 关键词：NOSIHEPTIDE Start codon Leader peptide BIOSYNTHESIS

Inhibitory effects of Tripterygium wilfordii multiglycoside on benign prostatic hyperplasia in rats被引量：5: 《Chinese Journal of Natural Medicines》2015年第6期421-427,共7页SHEN Hai-Nan XU Yuan JIANG Zhen-Zhou HUANG Xin ZHANG Lu-Yong WANG Tao; supported by National Natural Science Foundation of China(Nos.81173651,81320108029,and 81303301);2011 Program for Excellent Scientific,Technological Innovation Team of Jiangsu Higher Education;the 111 Project(No.111-2-07); The present study was designed to evaluate the inhibitory effects of Tripterygium wilfordii multiglycoside(GTW) against testosterone-induced benign prostatic hyperplasia(BPH) in rats. A total of 45 rats were randomly ...; 关键词：Tripterygium wilfordii Multiglycoside Benign prostatic hyperplasia TESTOSTERONE DIHYDROTESTOSTERONE

Discovery of novel aromatase inhibitors using a homogeneous time-resolved fluorescence assay被引量：2: 《Acta Pharmacologica Sinica》2014年第8期1082-1092,共11页Jin-zi JI Ke-jing LAO Jie HU Tao PANG Zhen-zhou JIANG Hao-liang YUAN Jing-shan MIAO Xin CHEN Shan-shan NING Hua XIANG Yu-meng GUO MingYAN Jie HU; This project was supported by ＂National Natural Science Foundation of China＂（No 81102876, 81373179）; Major Sci- entific and Technological Special Project for Significant New Drugs Creation （No 2012ZX09504001-001）; Jiangsu Province Science and Technology Support Program of Social Devel- opment Projects （BE2012745）; and this study was partially supported by the 111 Project （111-2-07）. Thanks to Mr Peng GAO for assistance with the experiments, Mounia GUERRAM for revision in language of the manuscript, and Dr Ya-dong CHEN for valuable suggestions.; Aim： Aromatase is an important target for drugs to treat hormone-dependent diseases, including breast cancer. The aim of this study was to develop a homogeneous time-resolved fluorescence （HTRF） aromatase assay sui...; 关键词：AROMATASE breast cancer imidazolyl quinoline triptoquinone A homogeneous time-resolved fluorescence assay high-throughput screening molecular docking drug discovery

Anti-inflammatory and hepatoprotective effects of total flavonoid C-glycosides from Abrus mollis extracts被引量：10: 《Chinese Journal of Natural Medicines》2014年第8期590-598,共9页CHEN Mi WANG Tao JIANG Zhen-Zhou SHAN Chun WANG Hao WU Mei-Juan ZHANG Shuang ZHANG Yun ZHANG Lu-Yong; supported by Mega-projects of Science Research for the 11th Five-Year Plan(No.2009ZX 09103-315);12th Five-Year Plan(No.2013ZX09301-303-003);the 111 Project(No.111-2-07);2011’Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education; The aim of this study was to evaluate the anti-inflammatory and hepatoprotective effects of the total flavonoid C-glycosides isolated from Abrus mollis extracts(AME). In the anti-inflammatory tests, xylene-induced ear...; 关键词：Abrus mollis Flavonoid C-glycosides INFLAMMATION Liver injury

Protective effect of total flavonoid C-glycosides from Abrus mollis extract on lipopolysaccharide-induced lipotoxicity in mice被引量：8: 《Chinese Journal of Natural Medicines》2014年第6期461-468,共8页WANG Yun JIANG Zhen-Zhou CHEN Mi WU Mei-Juan GUO Hong-Li SUN Li-Xin WANG Hao ZHANG Shuang WANG Tao ZHANG Lu-Yong; supported by the Mega-projects of Science Research for the 11th Five-Year Plan(No.2009ZX09103-315);the 12th Five-Year Plan(No.2013ZX09301-303-003);the 111 Project(No.111-2-07),the 2011’Program for Excellent Scientific;Technological Innovation Team of Jiangsu Higher Education and the Specific Fund for Public Interest Research of Traditional Chinese Medicine,Ministry of Finance(No.200707008);the National Natural Science Foundation of China(No.81172955); Abrus mollis is a widely used traditional Chinese medicine for treating acute and chronic hepatitis, steatosis, and fibrosis. It was found that the total flavonoid C-glycosides from Abrus mollis extract(AME) showed po...; 关键词：Flavonoid C-glycosides ENDOTOXIN Unfolded protein response Lipid metabolism Inflammation

芳香醇异构体在纤维素-三(3,5-二甲基苯基氨基甲酸酯)色谱柱上的手性分离(英文)被引量：3: 《中国药科大学学报》2014年第2期213-220,共8页吴旭日范宇陈依军; supported by the "111 Project" from the Ministry of Education of China and the State Administration of Foreign Expert Affairs of China(No.111-2-07);National Science and Technology Major Projects of China(No.2012ZX09103-101-030);and the Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.ZJ12009); 手性化合物的构型测定一般难度较大。本文在利用涂布纤维素-三(3,5-二甲基苯基氨基甲酸酯)(CDMPC)手性固定相的反相色谱柱Chiralcel OD-RH分析芳香醇异构体的过程中发现,芳香醇异构体的立体构型与其在手性柱上的色谱行为即洗脱顺序存在...; 关键词：CHIRALCEL OD—RH色谱柱芳香醇异构体纤维素-三(3 5二甲基苯基氨基甲酸酯)(CDMPC) 绝对构型手性识别机制

鸡骨草总黄酮碳苷对乙硫氨酸导致的小鼠脂肪肝的影响被引量：21: 《中国临床药理学与治疗学》2014年第1期1-7,共7页王昀陈蜜江振洲汪豪张陆勇; 国家"十一五"重大新药创制科技重大专项(2009ZX09103-315);国家"十二五"重大新药创制专项(2013ZX09301-303-003);高等学校学科创新引智计划(111-2-07);2011年度江苏省高等学校优秀科技创新团队(200707008);国家自然科学基金(81172955); 目的:研究鸡骨草总黄酮碳苷(AME)对乙硫氨酸(DL-E)所致小鼠脂肪肝的影响,并探讨其作用机制。方法:ICR小鼠随机分为4组:对照组,DL-E造模组,AME组和AME+DL-E组,每组8只。用AME连续灌胃给予AME组和AME+DL-E组小鼠7d,另外两组给予溶剂对照(...; 关键词：鸡骨草总黄酮碳苷肝损伤脂代谢固醇调节元件结合蛋白脂肪酸合成酶过氧化物酶体增殖物活化受体α

C-去甲-D-高甾烷甾体生物碱ABC环的合成:环巴胺的全合成研究(英文)被引量：1: 《中国天然药物》2013年第3期277-283,共7页张学丽廖雨琦蔡鹏俊姚和权孔令义孙宏斌; financially supported by the"111 Project"from the Ministry of Education of China and the State Administration of Foreign Expert Affairs of China(No.111-2-07);the program for Changjiang Scholars and Innovative Research Team in University(No.IRT1193);the program for research innovation to postgraduates of Jiangsu Province(No.02705181)~~; 本研究工作建立了一种合成环巴胺ABC环的有效方法。该方法的亮点在于扁桃酸缩醛介导的稠环酮(±)-4的拆分及IBX-介导的化合物12的多位点同步氧化。所建立的光学纯关键中间体(+)-4和2的简便合成方法为进一步合成具有生物活性的各种C-去甲...; 关键词：C-去甲-D-高甾烷甾体生物碱环巴胺合成

黄芩素抑制流感病毒A/FM1/1/47(H1N1)的一个新机理:干扰病毒中后期mRNA的合成(英文)被引量：16: 《中国天然药物》2012年第6期415-420,共6页苏真真窦洁徐志鹏郭青龙周长林; supported by the grants from the National Science and Technology Major Project Foundation of China (No. 2011ZX09102-009-05);the Fundamental Research Funds for the Central Universities (No. JKP2011018);the "111 Project"from the Ministry of Education of China and the State Administration of Foreign Expert Affairs of China (No. 111-2-07)~~; 目的:阐明黄芩素在细胞培养中对流感病毒A/FM1/1/47(H1N1)的抑制机理。方法:通过结晶紫染色实验测定黄芩素对流感病毒的抑制作用,采用不同加药方式进一步研究黄芩素对病毒复制周期不同阶段的影响。通过RT-PCR方法比较黄芩素给药组和病...; 关键词：黄芩素流感病毒抗病毒机理 mRNA合成

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