云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(30925042)

国家自然科学基金(30925042): 作品数：10被引量：87H指数：5; 导出分析报告; 相关作者：陈道峰程志红卢燕何常明沈路路更多>>; 相关机构：复旦大学更多>>; 相关期刊：《Chinese Journal of Natural Medicines》《中草药》《World Journal of Traditional Chinese Medicine》《Journal of Chinese Pharmaceutical Sciences》更多>>; 相关主题：POLYSACCHARIDESANTI-COMPLEMENTBUPLEURUM抗补体活性FEVER更多>>; 相关领域：医药卫生理学更多>>

Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling被引量：16: 《Chinese Journal of Natural Medicines》2019年第9期641-649,共9页LIU Zhen-Zhen WENG Hong-Bo ZHANG Li-Jie PAN Ling-Yu SUN Wei CHEN Hai-Xia CHEN Mei-Yu ZENG Tao ZHANG Yun-Yi CHEN Dao-Feng LI Hong; funded by the National Natural Science Foundation of China(Nos.81673658,81274165 and 30925042);Ministry of Science and Technology of China(No.2018ZX09735003-002);the Science and Technology Commission of Shanghai Municipality(No.12JC1400800); Bupleurum polysaccharides(BPs)is isolated from Bupleurum smithii var.parvifolium,a key traditional Chinese medicine.The study was to investigate the effects of BPs on diabetic kidney injury.After two intraperitoneal i...; 关键词：RENAL injury Bupleurum:High-mobility group box TOLL-LIKE receptor 4 Inflammation RENAL FIBROSIS POLYSACCHARIDES

Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities被引量：22: 《Acta Pharmaceutica Sinica B》2018年第2期218-227,共10页Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen; supported by grants from the National Natural Science Foundation of China(81330089,30925042,and 30801508);the Ministry of Science and Technology of China(2012ZX09301001-003); Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysac...; 关键词：Houttuynia cordata POLYSACCHARIDES FEVER Acute lung injury Anti-complementary

Polymyxin B as an inhibitor of lipopolysaccharides contamination of herb crude polysaccharides in mononuclear cells: 《Chinese Journal of Natural Medicines》2017年第7期487-494,共8页LU Xiao-Xiao JIANG Yi-Fan LI Hong OU Ying-Ye ZHANG Zhi-De DI Hong-Ye CHEN Dao-Feng ZHANG Yun-Yi; supported by the National Natural Science Foundation of China(Nos.81330089,30925042,and 81274165);the State Key Program for New Drugs from the Ministry of Science and Technology,China(No.2012ZX09301001-003);the Science and Technology Commission of Shanghai Municipality(Nos.10XD1405900 and 12JC1400800); Lipopolysaccharides(LPS) contamination in herbal crude polysaccharides is inevitable. The present study was performed to explore the effect of polymyxin B on abolishing the influence of LPS contamination in mononuclea...; 关键词：Lipopolysaccharide POLYMYXIN B BUPLEURUM CHINENSIS polysaccharides Mouse PERITONEAL macrophages RAW264.7 cells

ISOLATION, CHARACTERIZATION AND MEDICAL PROPERTIES OF ANTICOMPLEMENT AGENTS FROM TRADITIONAL CHINESE MEDICINES: 《World Journal of Traditional Chinese Medicine》2015年第4期70-71,共2页Daofeng Chen; The National Natural Science Foundation of China(NO.81330089 and 30925042); The inappropriate activation of complement system may cause some life-threatening symptoms such as rheumatoid arthritis,systemic lupus erythematosus(SLE)and acute respiratory distress syndrome(ARDS).In our efforts to ...; 关键词：SLE CHARACTERIZATION AND MEDICAL PROPERTIES OF ANTICOMPLEMENT AGENTS FROM TRADITIONAL CHINESE MEDICINES

Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides被引量：1: 《Acta Pharmaceutica Sinica B》2015年第4期316-322,共7页Mulu Wu Hong Li Yunyi Zhang Daofeng Chen; supported by grants from the National Natural Science Foundation of China (Nos. 81274165, 81330089 and 30925042);the State Key Program for Innovative Drugs from the Ministry of Science and Technology of the people’s Republic of China (No. 2012ZX09301001-003);the Science and Technology Commission of Shanghai Municipality (Nos. 12JC1400800 and 10XD1405900);Fudan's Undergraduate Research Opportunities Program (Xiyuan, No. 102305); Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of compleme...; 关键词：ELISA Complement C3c SURAMIN Bupleurum smithti var. parvifolium Bupleurum chinense POLYSACCHARIDES

虎杖的抗补体活性蒽醌类成分及其作用靶点被引量：17: 《中草药》2013年第18期2502-2507,共6页沈路路卢燕程志红陈道峰; 国家自然科学基金资助项目(30925042);科技部重大专项资助项目(2009ZX09502-013);<中国药典>国家药品标准提高研究项目(369;虎杖); 目的研究虎杖Polygonum cuspidatum中的抗补体活性蒽醌类成分及其作用靶点。方法采用溶血试验法进行抗补体活性成分的导向分离，对所得化合物进行抗补体活性测定，并利用补体缺失血清鉴定主要活性化合物的作用靶点。结果从虎杖醋酸...; 关键词：虎杖蒽醌类化合物抗补体活性大黄素迷人醇

广藿香的抗补体活性成分被引量：14: 《中国中药杂志》2013年第13期2129-2135,共7页阮姝楠卢燕陈道峰; 国家自然科学基金项目(30925042);国家"重大新药创制"科技重大专项(2009ZX09502-013); 采用硅胶、Sephadex LH-20等柱色谱方法对广藿香进行抗补体活性导向分离与鉴定,从乙酸乙酯部位和正丁醇部位共分离鉴定了15个黄酮、1个三萜和2个酚酸类成分,包括5-羟基-3,7,3',4'-四甲氧基黄酮(1)、5-羟基-7,3',4'-三甲氧基-二氢黄酮(2)...; 关键词：广藿香化学成分抗补体活性黄酮槲皮素-7 3′ 4′-三甲醚

山豆根中黄酮类成分的LC/MS定性分析与HPLC含量测定(英文)被引量：20: 《中国天然药物》2013年第6期690-698,共9页何常明程志红陈道峰; supported by the National Natural Science Foundation(Nos.30672597,30925042);the State Key Program for the Innovative Drugs from the Ministry of Science and Technology(No.2009ZX09502-013),China~~; 目的:建立山豆根中黄酮类成分的定性、定量分析方法,完善药材质量控制手段。方法:以HPLC-DAD-ESI-MS方法,对山豆根中黄酮类成分进行在线分离与定性鉴定;以HPLC方法同时测定山豆根药材中5个主要活性黄酮的含量。结果:从山豆根中共鉴定了1...; 关键词：山豆根黄酮定性分析含量测定 LC MS HPLC

Anti-complement constituents of Commelina communis and their targets in complement activation cascade: 《Journal of Chinese Pharmaceutical Sciences》2012年第6期577-581,共5页金家宏程志红陈道峰; National Natural Science Foundation for ExcellentYouth (Grant No.30925042);State Key Program for the InnovativeDrugs from the Ministry of Science and Technology (Grant No.2009ZX09502-013 and 2009ZX09301-011); Anti-complement activity guided fractionation led to the isolation of 24 compounds from Commelina communis.Bioassay showed that six compounds inhibited the classical pathway and alternative pathway with CH 50 values o...; 关键词：Commelina communis Chemical constituents Complement inhibitor Action targets

Simultaneous determination of six steroidal saponins and one ecdysone in Asparagus filicinus using high performance liquid chromatography coupled with evaporative light scattering detection被引量：2: 《Acta Pharmaceutica Sinica B》2012年第3期267-273,共7页Libo Zhou Zhihong Cheng Daofeng Chen; This investigation was supported by the grants from the Science and Technology Commission of Shanghai Municipality(04DZ19806);the Natural Science Foundation of China(30925042);the State Key Program from the Ministry of Science and Technology,China(2009ZX09502-013).; A high-performance liquid chromatography coupled with an evaporative light scattering detector(HPLC-ELSD)has been developed to evaluate the quality of Asparagus filicinus through a simultaneous determination of six st...; 关键词：HPLC-ELSD Asparagus filicinus Steroidal saponin ECDYSONE Aspafiliosides Filiasparoside A 20-HYDROXYECDYSONE Quality evaluation

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