国家自然科学基金(30571909)

作品数:7被引量:35H指数:3
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相关作者:陶陆阳陈溪萍杨丽刘冉张运阁更多>>
相关机构:苏州大学更多>>
相关期刊:《Neuroscience Bulletin》《中华神经医学杂志》《法医学杂志》更多>>
相关主题:CENTRAL_NERVOUS_SYSTEM大鼠脑LC3DEGENERATIONCATHEPSIN更多>>
相关领域:医药卫生更多>>
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NF-κB与神经系统损害的研究进展被引量:4
《法医学杂志》2008年第6期453-456,共4页张运阁 陶陆阳 
国家自然科学基金项目(30571909);江苏省"青蓝工程"骨干教师项目(BU134701);苏州大学医学发展基金(EE134615)资助
神经系统损害在法医学鉴定实践中较为常见,同时也是法医学鉴定的难点之一。近年来,国内外学者试图通过核转录因子-κB(nuclear factor-kappa B,NF-κB)的激活情况来为神经系统损害程度的法医学鉴定提供客观依据,并研究在神经系统损伤后...
关键词:法医学 NF—κB 综述[文献类型] 创伤 神经系统 神经系统疾病 
Regulation of axonal regeneration following the central nervous system injury in adult mammalian被引量:3
《Neuroscience Bulletin》2008年第6期395-400,共6页刘冉 陈溪萍 陶陆阳 
supported by the National Natural Science Foundation of China(No.30571909,No.30872666);the Youth Teacher Foundation of Jiangsu Pro-vince(No.BU134701);China,and the Medical Development Foundation of Soochow University(No.EE134615)
It has been well established that the recovery ability of central nervous system (CNS) is very poor in adult mammals. As a result, CNS trauma generally leads to severe and persistent functional deficits. Thus, the i...
关键词:central nervous system ADULT REGENERATION REGULATION brain injury 
NF-KB信号通路在脑损伤修复中的作用被引量:3
《中华神经医学杂志》2008年第6期642-645,共4页杨丽 倪宏 陈溪萍 陶陆阳 
国家自然科学基金(30571909);江苏省自然科学基金(BK2007509);江苏省“青蓝工程”优秀骨干教师项目(BU134701);苏州大学医学发展基金(EE134615)
核因子NF-KB(nuclear factor-kappa B,NF-KB)在感染和免疫反应及控制细胞分化和凋亡中起着重要的作用,这些作用在神经系统中很明显。神经元及其临近的细胞通过NF-KB通路表达不同的功能.这些功能包括从神经系统损伤后各种细胞的联...
关键词:脑修复 核因子-KB 神经保护 
Autophagy is activated and might protect neurons from degeneration after traumatic brain injury被引量:11
《Neuroscience Bulletin》2008年第3期143-149,共7页张延波 李生兴 陈溪萍 杨丽 张运阁 刘冉 陶陆阳 
This work was supported by the National Natural Science Foundation of China (No. 30571909); the Youth Teacher Foundation of Jiangsu Province (No. BU134701); Medical Development Foundation of Soochow University (No. EE 134615); We also thank Jin-Sheng YANG for his help in polishing the English language.
Objective To investigate changes of autophagy after traumatic brain injury (TBI) and its possible role. Methods Rat TBI model was established by controlled cortical injury system. Autophagic double membrane structur...
关键词:AUTOPHAGY apoptosis traumatic brain injury LC3 BECLINL NEURODEGENERATION 
Roles of NF-κB in central nervous system damage and repair被引量:3
《Neuroscience Bulletin》2007年第5期307-313,共7页杨丽 陶陆阳 陈溪萍 
National Natural Science Foundation of China (No. 30571909); the Youth Teacher's Research Foundation of Jiangsu Province, China (No. BU 134701 ); the Medical Development Foundation of Soochow University (No. EE134615).
NF-κB family is a kind of nuclear factors in B lymphocyte that can bind to the immunoglobulin κ-chain enhancer and enhance transcriptional activity. NF-κB/Rel proteins, as a dimeric transcription factor, control th...
关键词:NF-ΚB central nervous system INJURY REPAIR 
大鼠脑外伤后溶酶体酶Cathepsin-B和D的表达被引量:10
《法医学杂志》2006年第6期404-406,410,F0002,共5页张延波 陈溪萍 陶陆阳 秦正红 李生兴 杨丽 杨菊 张运阁 刘冉 
国家自然科学基金资助项目(30571909);国家博士后基金资助项目(32134006)
目的研究大鼠脑外伤后溶酶体酶cathepsin-B和-D是否被激活及其不同时段表达变化,阐述其与凋亡执行因子caspase-3表达的关系,并探讨对脑外伤诊断及形成时间的意义。方法采用自由落体打击法建立脑外伤动物模型,并对模型及对照样本进行免...
关键词:脑外伤 溶酶体 cathepsin—B cathepsin—D caspase-3 
Electroencephalogram and evoked potential parameters examined in Chinese mild head injury patients for forensic medicine被引量:1
《Neuroscience Bulletin》2006年第3期165-170,共6页Xi-Ping CHEN Lu-Yang TAO Andrew CN CHEN 
This work was supported in part by grants from National Natural Science Foundation of China (No. 30571909); China Postdoctoral Science Foundation (No. 32134006); Foundation of Soozhow University (No. Q4134405).
Objective To evaluate the usefulness of quantitative electroencephalogram (QEEG), flash visual evoked potential (F-VEP) and auditory brainstem responses (ABR) as indicators of general neurological status. Method...
关键词:mild traumatic brain injury CONCUSSION PATIENTS ELECTROENCEPHALOGRAM evoked potentials forensic 
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