国家重点基础研究发展计划(2012CB822100)

作品数：8被引量：17H指数：2
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相关作者：张嘉宁任一鑫李辉张文轩李中军更多>>
相关机构：北京大学大连医科大学大连理工大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《化学学报》《中国免疫学杂志》《Chinese Chemical Letters》更多>>
相关主题：OLIGOSACCHARIDET细胞学说理论免疫监视肿瘤发生发展更多>>
相关领域：理学医药卫生生物学化学工程更多>>
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The rapid assembling of oligosaccharides by the developed HASP strategy
《Chinese Chemical Letters》2018年第1期69-72,共4页Yunhe Wang Shuai Meng Tingting Yue Shuchun Li Zhongjun Li 
supported by the grants from the National Natural Science Foundation of China(No. 21232002);the National Basic Research Program of China(No. 2012CB822100)
A new carrier containing three hydrophobic octadecyls was employed to improve the yield and purity of the synthesized oligosaccharides, and the applicability of hydrophobic carrier for HASP （hydrophobically assisted ...
关键词：Hydrophobically assisted switching phaseRapid oligosaccharide assemblyHPLCElution system 
An efficient ionic liquid supported divergent assembly of 3,6-branched glucosamine-containing pentasaccharide被引量：1
《Chinese Chemical Letters》2014年第12期1525-1530,共6页Ze-Shen Gao Sheng Sun Wei Li Qing Ma Qing Li Zhong-Jun Li 
supported by the National Basic Research Program of China(973 Program,No.2012CB822100);the National Key Technology R&D Program "New Drug Innovation" of China (No.2012ZX09502001-001);the National Natural Science Foundation of China(Nos.91213301,21232002)
We utilized the glycosyl acceptor tagging method with ionic liquid support for synthesis of the core segment of Clostridium botulinum C2 toxin ligand through a divergent synthetic strategy without chromatographic puri...
关键词：Ionic liquid Oligosaccharide Rapid assembling 
Synthesis of L-glucose and L-galactose derivatives from D-sugars被引量：4
《Chinese Chemical Letters》2014年第9期1220-1224,共5页Tian-Yu Xia Yang-Bing Li Zhao-Jun Yin Xiang-Bao Meng Shu-Chun Li Zhong-Jun Li 
supported by the National Basic Research Program of China(973 Program,No.2012CB822100);the National Key Technology R&D Program‘‘New Drug Innovation’’ of China(No.2012ZX09502001-001);the National Natural Science Foundation of China(Nos.20972012 and 21232002)
An efficient route to prepare L-glucose and L-galactose is described. The L-sugars are achieved by using the strategy of switching the functional groups at C1 and C5 of D-glucose and D-mannose. The oxidation and reduc...
关键词：Carbohydrates L-Hexoses Head-to-tail inversions Oxidation DECARBOXYLATION One-pot procedure 
Scalable synthesis of salidroside被引量：2
《Journal of Chinese Pharmaceutical Sciences》2014年第7期446-453,共8页梁清照 李辉 张文轩 孟祥豹 李中军 
the National Basic Research Program of China(973 Program,Grant No.2012CB822100);the National Key Technology R&D Program"New Drug Innovation"of China(Grant No.2012ZX09502001-001);the National Natural Science Foundation of China(Grant No.21232002,21072016 and 21072017)
By analyzing the key steps that restricted the industrial synthesis of salidroside, selective protection of tyrosol with different acylation reagents was adopted. The strategy facilitated the crystallization of interm...
关键词：SALIDROSIDE Acylation of tyrosol CRYSTALLIZATION Scale up feasibility Synthesis 
肿瘤逃避T细胞免疫监视的研究进展被引量：8
《中国免疫学杂志》2014年第8期1124-1128,共5页任一鑫 张嘉宁 
973计划项目(2012CB822100);国家自然科学基金(31170774)资助
免疫监视学说最早是由Ehrlich于1909年提出的，其认为免疫系统的一个关键作用是识别并清除肿瘤，之后又不断有学者（ Burnet and Thomas ）完善免疫监视学说理论，认为免疫系统能够清除新生的肿瘤病变［1］。而肿瘤能够逃避免疫监视则...
关键词：肿瘤病变 免疫监视 T细胞 逃避 Thomas 肿瘤发生发展 免疫系统 学说理论 
Neamine-heterocycle conjugates as potential anti-HIV agents
《Chinese Chemical Letters》2013年第4期273-278,共6页Ri-Bai Yan Yan-Fen Wu Jun Liu Xiao-Lian Zhang Xin-Shan Ye 
financially supported by the Ministry of Science and Technology of China(Nos.2012ZX09502001-001, 2012CB822100,and 2012CB720604);the National Natural Science Foundation of China(Nos.81025008 and 30921001)
A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV...
关键词：AMINOGLYCOSIDE ANTI-HIV Neamine SYNTHESIS 
基于Diels-Alder生物正交反应的蛋白质快速位点特异性标记方法被引量：1
《化学学报》2012年第21期2208-2212,共5页王玥 叶新山 
科技部"973"计划(No.2012CB822100);"重大新药创制"科技重大专项(No.2012ZX09502001-001)资助~~
蛋白质的位点特异性修饰近年来取得了重要进展.本文对该领域新近发展的利用高张力烯烃或炔烃与四嗪类化合物的Diels-Alder生物正交反应,通过基因编码的方式在蛋白质中位点特异性地插入其中一个组分,从而实现蛋白质的快速荧光标记进行了...
关键词：蛋白质标记 荧光探针 生物正交反应 四嗪 基因编码 非天然氨基酸 
Synthesis of an antimetastatic tetrasaccharide β-D-Gal-(1→4)-β-d-GlcpNAc-(1→6)-α-D-Manp-(1→6)-β-D-Manp-OMe被引量：1
《Chinese Chemical Letters》2012年第12期1371-1374,共4页Kai Jun Liao Xiao Feng Jin Xiang Bao Meng Chen Li Zhong Jun Li 
supported by the National Basic Research Program of China(973 program,No.2012CB822100);the National Natural Science Foundation of China(No.20972012)
An antimetastatic tetrasaccharide β-D-Gal-（1 → 4）-β-D- GlcpNAc-（1 →6）-α-D-Manp-（1 → 6）-β-D-Manp-OMe, was syn- thesized with two approaches. The first approach was a conventional method employing thioglyc...
关键词：Antimetastatic tetrasaccharide THIOGLYCOSIDE Koenigs-Knorr method Azidoiodo-glycosylation 2-Iodo-2-deoxyl-actosyl azide β-Methyl mannoside 
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