云南高校图书馆联盟文献共享服务平台- 高等学校学科创新引智计划(B07023)

高等学校学科创新引智计划(B07023): 作品数：11被引量：26H指数：3; 导出分析报告; 相关作者：沈杰唐赟李卫华程飞雄更多>>; 相关机构：京都大学华东理工大学更多>>; 相关期刊：《Science China Chemistry》《农药学学报》《Chinese Chemical Letters》《Acta Pharmaceutica Sinica B》更多>>; 相关主题：ACTIVATORSALDEHYDESENAMINESIMAGINGAMYLOID更多>>; 相关领域：化学工程理学医药卫生自动化与计算机技术更多>>

Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s disease被引量：2: 《Acta Pharmaceutica Sinica B》2020年第4期646-666,共21页Xiaokang Li Jian Lu Yixiang Xu Jiaying Wang Xiaoxia Qiu Lei Fan Baoli Li Wenwen Liu Fei Mao Jin Zhu Xu Shen Jian Li; provided by the National Sciences and Technology Major Project of China,(2018ZX09711002-003-010);the National Natural Science Foundation of China,(81872747,21672064);the 111 Project(B07023,China);the Chinese Postdoctoral Science Foundation(2018M641946);the Shanghai Sailing Program(19YF1412600,China);the Shanghai Morning Light Program(18CG33,China);the National Special Fund for State Key Laboratory of Bioreactor Engineering(2060204,China);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX18_1600,China).; Drug repurposing is an efficient strategy for new drug discovery.Our latest study found that nitazoxanide(NTZ),an approved anti-parasite drug,was an autophagy activator and could alleviate the symptom of Alzheimer’s ...; 关键词：Alzheimer’s disease AUTOPHAGY NITAZOXANIDE Β-AMYLOID Tau protein

In sights into the antineoplastic mechanism of Chelidonium majus via systems pharmacology approach被引量：1: 《Frontiers of Electrical and Electronic Engineering in China》2019年第1期42-53,共12页Xinzhe Xiao Zehui Chen Zengrui Wu Tianduanyi Wang Weihua Li Guixia Liu Bo Zhang Yun Tang; the National Key Research and Development Program of China (No. 2016YFA0502304);the National Natural Science Foundation of China (Nos. 81673356 and U1603122);the 111 Project (No. B07023).; Background: The antineoplastic activity of Chelidonium majus has been reported, but its mechanism of action (MoA) is unsuspected. The emerging theory of systems pharmacology may be a useful approach to analyze the com...; 关键词：SYSTEMS phannacology MECHANISM of action TRADITIONAL Chinese MEDICINE Chelidonium majus

A pinacol boronate caged NIAD-4 derivative as a near-infrared fluorescent probe for fast and selective detection of hypochlorous acid被引量：1: 《Chinese Chemical Letters》2018年第1期139-142,共4页Hongjuan Tong Yajun Zhang ShengnanMa Minghao Zhang Na Wang Rui Wang Kaiyan Lou Wei Wang; supported by the China 111 Project(No. B07023, W. Wang);East China University of Science and Technology(startup funds, W. Wang);the National Natural Science Foundation of China(No. 21577037, K. Lou);the Fundamental Research Funds for the Central Universities(No. ECUST-WY1213013,K. Lou); Hypochlorous acid （HOCI） is one of highly reactive oxygen species （ROS）. It is involved in both immune defense against invading microbes and the progression of many diseases including cardiovascular disease and ne...; 关键词：Fluorescent probeHypochlorous acidBoronateReactive oxygen species （ROS）Near-infrared （NIR） imaging

Design,synthesis and evaluation of PPAR gamma binding activity of 2-thioxo-4-thiazolidinone derivatives: 《Chinese Chemical Letters》2015年第1期63-68,共6页Li Zhou Ye Zhong Meng-Zhu Xue Dong Kuang Xian-Wen Cao Zhen-Jiang Zhao Hong-Lin Li Yu-Fang Xu Rui Wang; supported by the National Natural Science Foundation of China(Nos.81072627,81230090 and 81222046);Shanghai Committee of Science and Technology(Nos.12431900901 and 12401900801);the Fundamental Research Funds for the Central Universities(111 Project,No.B07023); We designed and synthesized a series of 2-thioxo-4-thiazolidinone derivatives and evaluated them on peroxisome proliferator activated receptor γ（PPARγ） binding activities.Through the biological assays,compounds 18...; 关键词：2-Thioxo-4-thiazolidinone Peroxisome proliferator activated receptorγ Binding activities SAR Molecular docking

Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease被引量：11: 《Acta Pharmaceutica Sinica B》2015年第1期25-33,共9页Hongjuan Tong Kaiyan Lou Wei Wang; supported by the Fundamental Research Funds for the Central Universities and East China University of Science and Technology (start-up funds, Wei Wang);the China 111 Project (Grant B07023, Wei Wang); One of the early pathological hallmarks of Alzheimer's disease(AD) is the deposition of amyloid-β(Aβ) plaques in the brain. There has been a tremendous interest in the development of Aβ plaques imaging probes for e...; 关键词：Alzheimer’s disease Blood-brain barrier Fluorescence probe Near-infrared fluorescence Optical imaging Amyloid-β plagues

Novel plant activators with thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate scaffold: Synthesis and bioactivity被引量：4: 《Chinese Chemical Letters》2013年第11期967-969,共3页Qing-Shan Du Yan-Xia Shi Peng-Fei Li Zhen-Jiang Zhao Wei-Ping Zhu Xu-Hong Qian Bao-Ju Li Yu-Fang Xu; financially supported by the National Basic Research Program of China (973 Program, No. 2010CB126100);the National High Technology Research and Development Program of China (863 Program, No. 2011AA10A207);the China 111 Project (No. B07023);the Fundamental Research Funds for the Central Universities.; The 1,2,3-thiadiazole-carboxylate moiety was reported to be an important pharmacophore of plant activators.In this study,a series of novel plant activators based on thieno[2,3-d]-1,2,3-thiadiazole-6-carboxylate were d...; 关键词：Thieno[2 3-d]-1 2 3-thiadiazole-6-carboxylate derivatives Plant activator Systemic acquired resistance

Comparative pharmacophore modeling of human adenosine receptor A1 and A3 antagonists: 《Science China Chemistry》2012年第11期2407-2418,共12页XU ZheJun CHENG FeiXiong LI Jie ZHOU YaDi SU Ni LI WeiHua LIU GuiXia TANG Yun; supported by the National Natural Science Foundation of China (21072059);the Program for New Century Excellent Talents in University (NCET-08-0774);the 111 Project (B07023);the Shanghai Committee of Science and Technology (11DZ2260600);the Fundamental Research Funds for the Central Universities (WY1113007);the National S&T Major Project of China ( 2009ZX09501-001); Adenosine receptors are promising therapeutic targets in drug discovery. In this study, three-dimensional pharmacophore mod- els of human adenosine receptor A1 and A3 antagonists were developed based on 26 and 23 dive...; 关键词：pharmacophore modeling adenosine receptors ANTAGONISTS enrichment factor simulated virtual screening

A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-L-proline with aldehydes: 《Science China Chemistry》2012年第1期43-49,共7页ZOU ZhiQin DENG ZeJun YU XinHong ZHANG ManMan ZHAO SiHan LUO Ting YIN Xin XU HUi WANG Wei; support from the National Natural Science Foundation of China(20972051);the Science and Technology Commission of Shanghai Municipality(08430703900 & 08431901800);the 111 Project(B07023);East China University of Science & Technology; An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-L-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions.; 关键词：AROMATIZATION DECARBOXYLATION ENAMINES IMINIUM redox isomerization

Efficient preparation of trans-α,β-unsaturated aldehydes from saturated aldehydes by oxidative enamine catalysis: 《Science China Chemistry》2011年第12期1932-1936,共5页ZHANG ShiLei XIE HeXin SONG AiGuo WU DeYan ZHU Jin ZHAO SiHan LI Jian YU XinHong WANG Wei; the financial support from the National Science Foun-dation (CHE-1057569,W. W.);the China 111 Project (B07023,J. L. and W. W.);the National Natural Science Foundation of China (20972051,X. Y.-H.);the Science and Technology Commission of Shanghai Mu-nicipality (08430703900 & 08431901800,X. Y.-H.); A mild and highly efficient amine-catalyzed, IBX-mediated oxidation of aldehydes to （E） selective a, β-unsamrated aldehydes has been achieved in good yields. The process features a new oxidation of enamines to imin...; 关键词：ALDEHYDES ENALS ENAMINES IBX oxidative enamine catalysis

有机化合物的陆地和水生环境毒性的计算机预测研究(英文)被引量：3: 《农药学学报》2010年第4期477-488,共12页程飞雄沈杰李卫华 Philip W.LEE 唐赟; Program for New Century Excellent Talents in University ( Grant No NCET-08-0774);the National S & T Major Project of China ( Grant No 2009ZX09501-001);the 111 Project ( Grant No B07023); 采用子结构模式识别结合 5 种机器学习方法( 包括支持向量机、C4. 5决策树、k-最近邻法、随机森林法、和朴素贝叶斯法) ,分别构建了有机化合物对水生和陆地环境毒性评价的两个重要生物靶标——呆鲦鱼( Fathead minnow) 和蜜蜂毒性的定...; 关键词：呆鲦鱼毒性蜜蜂毒性定量结构-活性相关性(QSAR) 子结构模式识别信息熵支持向量机

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