国家自然科学基金(30670477)

作品数：9被引量：21H指数：2
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相关机构：东北师范大学吉林大学中日联谊医院吉林大学更多>>
相关期刊：《科学通报》《高等学校化学学报》《Chemical Research in Chinese Universities》《Science Bulletin》更多>>
相关主题：AQUAPORINNPAAQUAPORIN-1CURCUMINCFTR更多>>
相关领域：生物学医药卫生理学轻工技术与工程更多>>
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Aquaporin-3 Deletion Reduces Glycerol and ATP Content in Mouse Sciatic Nerve被引量：2
《Chemical Research in Chinese Universities》2010年第6期955-957,共3页ZHANG Di GUO Lei ZHU Na SU Wei-heng GUAN Xin-gang YI Fei HAO Feng XIAO Ying-hong LIU Jia LIU Tian-zhou MA Tong-hui 
Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405,30570864,30670477 and 30770493)and the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011)
We reported the expression and function of aquaglyceroporin AQP3 in mouse peripheral nervous system.AQP3 mRNA was identified in freshly isolated mouse sciatic nerve by RT-PCR.Immunofluorescence using AQP3 antibody loc...
关键词：AQUAPORIN Sciatic nerve myelin GLYCEROL ATP 
Remarkably Decreased CD11b Positive Splenocytes in Aquaporin 3-Null Mice
《Chemical Research in Chinese Universities》2010年第2期217-220,共4页ZHU Na QIAO Ying ZHANG Di WANG Wen-juan LIU Jia LIU Tian-zhou MA Tong-hui 
Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405, 30570864,30670477 and 30770493);the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011)
Aquaporins（AQPs） are molecular water channels that play important physiological roles in fluid trans-porting organs. The expression and function of AQPs in the immune system are largely unknown. CD 11 （a-d）/CD18 i...
关键词：AQUAPORIN SPLENOCYTE CD1 lb Flow cytometry 
20(S)-原人参二醇促进CFTR氯离子通道开放被引量：6
《高等学校化学学报》2008年第4期731-735,共5页刘军 那万里 辛伟红 刘丽丹 于波 麻彤辉 杨红 
国家自然科学基金(批准号:30470405,30570864,30670477);吉林省杰出青年基金(批准号:20030112);教育部青年骨干教师奖励计划;留学回国人员科研基金资助
利用氯离子通道细胞荧光测定模型对386种中药单体化合物进行筛选,发现20(S)-原人参二醇对依赖于cAMP的CFTR氯离子通道具有激活作用.20(S)-原人参二醇能够以剂量依赖的方式激活野生型CFTR氯离子通道,其激活作用通过更为可靠的氯离子通道...
关键词：囊性纤维化 CFTR氯离子通道 突变 天然化合物 激活剂 
Natural Compound Curcumin—a Channel Potentiator Rather Than a Corrector of the Defective Intracellular Processing of △F508 Mutant Cystic Fibrosis Transmembrane Conductance Regulator被引量：1
《Chemical Research in Chinese Universities》2008年第2期200-203,共4页LIU Xin GUAN Li HE Cheng-yan ZHANG Xiao-jing XU Li-na SHANG De-jing MA Tong-hui YANG Hong 
Supported by the National Natural Science Foundation for Distinguished Young Scholars(No30325011);National Natural Science Foundation of China(Nos30570864 and 30670477);Program for New Century Excellent Talents in University(No NCET-07-0406)
Cystic fibrosis（CF） is a severe genetic disease caused by the gene mutation of the cystic fibrosis transmembrane conductance regulator（CFTR） chloride channel. The most common point mutation AF508, which leads to i...
关键词：Cystic tibrosis CFTR Mutation Natural compound Drug discovery 
Natural Compound Curcumin Corrects the Gating Defect of G551DMutant Cystic Fibrosis Transmembrane Conductance Regulator
《Chemical Research in Chinese Universities》2008年第1期92-95,共4页HAO Li-ming LIU Xin XU Li-na ZHU Na LIN Sen HOU Shu-guang ZHOU Na SHI De-cheng SHANG De-jing MA Tong-hui YANG Hong 
National Natural Science Fund for Distinguished Young Scholars(No.30325011);National Natural Science Foundation of China(Nos.30470405, 30570864, 30670477);Distinguished Young Scholars Fund of Jilin Province (No.20030112) ;Excellent Young Teachers Program of Ministry of Education, China
In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore...
关键词：Cystic fibrosis CFTR MUTATION Natural compound ACTIVATOR 
Prokaryotic Expression,Purification,Antibody Production of a NH_2-Terminal Fragment of mCLCA3 Protein and Analysis of mClCA3 Protein Expression in Asthmatic Mouse Lung被引量：1
《Chemical Research in Chinese Universities》2007年第6期688-692,共5页HOU Xia WU Qing-tian ZHANG Yu-ping ZHU Na LIU Yan-li FENG Xue-chao MA Tong-hui 
Supported by the Distinguished Young Scholars Fund of China(No.30325011);the National Natural Science Foundation of China(Nos.30470405and30670477);Distinguished Young Scholars Fund of Jilin Province,China(No.20030112);Excellent Young Teachers Program of MOE,China.
mCLCA3 is a member of calcium activated chloride channel（CACC） family that may play an important role in mucin packaging and secretion in asthmatic and cystic fibrosis lung. To study the protein structure and expres...
关键词：mCLCA3 Prokaryotic expression PURIFICATION Antibody production ASTHMA 
Reduced Bone Mineral Density and Bone Metabolism in Aquaporin-1 Knockout Mice被引量：2
《Chemical Research in Chinese Universities》2007年第3期297-299,共3页WU Qing-tian MA Qing-jie HE Cheng-yan WANG Cai-xia GAO Shi HOU Xia MA Tong-hui 
Supported by the National Natural Science Foundation of China(Nos30470405 and 30670477);National Natural ScienceFund for Distinguished Young Scholars(No30325011);Distinguished Young Scholars Fund of Jilin Province(No20030112);Excellent Young Tea
An overt phenotype of aquaporin-1 knockout（AQP1 ko） mice is growth retardation, suggesting possible defects in bone development and metabolism. In the present study, we analyzed the bone mineral density（ BMD）, bon...
关键词：AQUAPORIN Gene knockout Bone mineral density Bone metabolism 
Importance of NPA motifs in the expression and function of water channel aquaporin-1被引量：1
《Chinese Science Bulletin》2007年第6期771-776,共6页JIANG Yong MA TongHui 
Supported by the National Natural Science Foundation of China for Distinguished Young Scholars (Grant No. 30325011);National Natural Science Foundation of China (Grant Nos. 30470405 and 30670477);Distinguished Young Scholars Fund of Jilin Province (Grant No. 20030112);Excellent Young Teachers Program of Ministry of Education of China
The asparagine-proline-alanine sequences (NPA motifs) are highly conserved in aquaporin water channel family. Crystallographic studies of AQP1 structure demonstrated that the two NPA motifs are in the narrow central c...
关键词：水通道蛋白-1 NPA模体 基因表达 功能 突变发生 
NPA motif在水通道蛋白AQP1表达和转水功能中的重要性被引量：8
《科学通报》2007年第4期426-431,共6页姜勇 麻彤辉 
国家杰出青年科学基金(批准号:30325011);国家自然科学基金(批准号:30470405和30670477);吉林省杰出青年科学基金(批准号:20030112);教育部青年骨干教师资助计划资助项目
水通道蛋白(AQP)序列中的两个天冬酰胺-脯氨酸-丙氨酸序列(NPA motif)是水通道蛋白家族中高度保守的特征性序列,其晶体结构研究显示,两个NPA motifs位于通道中心的狭窄部位,直接参与水分子的结合和选择性通过.为了进一步研究两个NPA mot...
关键词：水通道蛋白 NPA MOTIF 突变 水通透性 生源学(biogenesis) 
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