国家重点基础研究发展计划(2010CB912102)

作品数：5被引量：25H指数：3
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相关期刊：《Acta Pharmacologica Sinica》《Acta Biochimica et Biophysica Sinica》《Journal of Molecular Cell Biology》《Protein & Cell》更多>>
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Lysyl oxidase promotes bleomycin-induced lung fibrosis through modulating inflammation被引量：3
《Journal of Molecular Cell Biology》2014年第6期506-515,共10页Tao Cheng Qingbo Liu Rui Zhang Ying Zhang Jianfeng Chen Ronghuan Yu Gaoxiang Ge 
This work was supported by the National Basic Research Program of China （2010CB912102 and 2010CB529703） and the National Natural Science Foundation of China （31190061, 31371408, and 81430067）. G.G. is a scholar of the SA-SIBS Scholarship Program.
Enzymes involved in collagen biosynthesis, including lysyl oxidase （LOX）, have been proposed as potential therapeutic targets for idio- pathic pulmonary fibrosis. LOX expression is significantly upregulated in bleom...
关键词：lysyl oxidase lung fibrosis INFLAMMATION BLEOMYCIN animal models extracellular matrix 
Proteomic profiling of lipid droplet-associated proteins in primary adipocytes of normal and obese mouse被引量：3
《Acta Biochimica et Biophysica Sinica》2012年第5期394-406,共13页Yubo Ding Yibo Wu Rong Zeng Kan Liao 
This work was supported by the grants from the Ministry of Science and Technology of China （2010CB912102）, from the National Natural Science Foundation of China （30821065 and 30870559）.
Lipid droplets in adipocytes serve as the principal long- term energy storage depot of animals. There is increasing recognition that lipid droplets are not merely a static neutral lipid storage site, but in fact dynam...
关键词：PROTEOMICS OBESITY lipid droplet-associatedprotein primary adipocyte 
Establishment and characterization of primary lung cancer cell lines from Chinese population被引量：6
《Acta Pharmacologica Sinica》2011年第3期385-392,共8页Chao ZHENG Yi-hua SUN Xiao-lei YE Hai-quan CHEN Hong-bin JI 
This work was supported by the National Basic Research Program of China （2010CB912102）, the National Natural Science Foundation of China （30871284 and 30971461）, the Chinese Academy of Sciences （KSCX1-YW-22）, and the Science and Technology Commission of Shanghai Municipality （08PJ14105, 09JC1416300）. Hong-bin JI is a scholar of the Hundred Talents Program of the Chinese Academy of Sciences.
Aim： To establish and characterize primary lung cancer cell lines from Chinese population. Methods： Lung cancer specimens or pleural effusions were collected from Chinese lung cancer patients and cultured in vitro w...
关键词：lung cancer primary cell lines epidermal growth factor receptor small cell lung carcinomas non-small cell lung carcinomas 
LKB1 in lung cancerigenesis:a serine/threonine kinase as tumor suppressor被引量：8
《Protein & Cell》2011年第2期99-107,共9页Yijun Gao Gaoxiang Ge Hongbin Ji 
the National Basic Research Program of China(Grant No.2010CB912102);the National Natural Science Foundation of China(Grant Nos.30871284,30971461 and 30971495);the Science and Technology Commission of Shanghai Municipality(No.09JC1416300)。
Lung cancer is featured with high mortality,with a 15%five-year survival rate worldwide.Genetic alterations,such as loss of function of tumor suppressor genes,frequently contribute to lung cancer initiation,progressio...
关键词：liver kinase B1 lung cancer tumor suppressor 
Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female never-smokers被引量：5
《Acta Pharmacologica Sinica》2010年第5期647-648,共2页Yi-hua SUN Rong FANG Bin GAO Xiang-kun HAN Jun-hua ZHANG William PAO Hai-quan CHEN Hong-bin JI 
Acknowledgements This work was supported by the National Basic Research Program of China （No 2010CB912102）, the National Natural Science Foundation of China （No 30623003, 30740084, and 30871284）, the Chinese Academy of Sciences （No 2008KIP101, KSCX1-YW-22）, the Science and Technology Commission of Shanghai Municipality （No 08PJ14105, 09JC1416300） and the Hundred Talents Program of the Chinese Academy of Sciences to Prof Hong-bin JI.
Lung cancer patients with the epidermal growth factor receptor （EGFR） kinase domain mutations frequently show good responses to small molecule tyrosine kinase inhibitors, including Iressa and Tarceva, in clinical st...
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