国家重点基础研究发展计划(National973program)

作品数：8被引量：5H指数：1
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Self-assembly Polyrotaxanes Nanoparticles as Carriers for Anticancer Drug Methotrexate Delivery
《Nano-Micro Letters》2014年第2期108-115,共8页Longgui Zhang Ting Su Bin He Zhongwei Gu 
supported by National Science Foundation for Excellent Young Scholars (No. 51222304);National Science Foundation of China (NSFC, No.31170921,51133004);National Basic Research Program of China (National 973 program, No. 2011CB606206);program for Changjiang Scholars and Innovative Research Team in University (IRT1163)
α-Cyclodextrin/poly(ethylene glycol)(α-CD/PEG) polyrotaxane nanoparticles were prepared via a self-assembly method. Anticancer drug methotrexate(MTX) was loaded in the nanoparticles. The interaction between MTX and ...
关键词：Polyrotaxane nanoparticles Drug delivery METHOTREXATE Anticancer activity 
Preparation and Biosafety Evaluation of the Peptide Dendron Functionalized Mesoporous Silica Nanohybrid
《Chinese Journal of Chemistry》2014年第1期27-36,共10页Dayi Pan Chunhua Guo Kui Luo Zhongwei Gu 
The work was supported by National Basic Research Program of China (National 973 program,No.2011CB606206),National Natural Science Foundation of China (51133004 and 81101099) and the Excellent Young Teachers Program of Sichuan University (2012SCU04A06).
Mesoporous silica nanoparticles (MSNs) have been extensively studied and proposed as promising candidates for numerous biomedical applications.In this study,we report the design,preparation,characterization and biosaf...
关键词：mesoporous silica nanoparticles peptide dendrimer NANOHYBRID toxicity BIOSAFETY 
Effect of serum on PEGylated quantum dots:Cellular uptake and intracellular distribution
《Progress in Natural Science:Materials International》2013年第6期566-572,共7页Yeting Jian Xianghui Xu Yunkun Li Zhongwei Gu 
supported by National Science Foundation of China(NSFC,No.51133004);National Basic Research Program of China(National 973 program,No.2011CB606206);Joint Sino-German Research Project(No.GZ756)
Protein adsorption is closely related with the interactions between nanoparticles and physiological systems,and further influences the cellular uptake and distribution of nanoparticles in cells.Although polyethylene g...
关键词：PEGylated QDS Protein adsorption CELLULAR UPTAKE INTRACELLULAR distribution 
Synthesis of peptide dendrimers with polyhedral oligomeric silsesquioxane cores via click chemistry被引量：3
《Chinese Chemical Letters》2013年第10期917-920,共4页Yu-Ji Pu Hui Yuan Ming Yang Bin He Zhong-Wei Gu 
supported by the National Basic Research Program of China(National 973 program,No.2011CB606206);National Science Foundation of China(NSFC,Nos.31170921,51133004);the National Science Foundation for Excellent Young Scholars(No.51222304);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1163)
Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite ...
关键词：Peptide dendrimer Polyhedral oligomeric silsesquioxane Click chemistry 
STUDIES ON THE DEGRADATION OF POLY(L-LACTIDE-r-TRIMETHENE CARBONATE) COPOLYMERS
《Chinese Journal of Polymer Science》2013年第7期966-973,共8页Yuan-lin Li Sai Li Li-jie Ji Bin He 顾忠伟 
financially supported by the National Basic Research Program of China (National 973 program,No. 2011CB606206);the National Natural Science Foundation of China (Nos. 50830105, 51133004);Program for New Century Excellent Talents in Universities, Ministry of Education (MOE, NCET-10-0564);Program for Changjiang Scholars and Innovative Research Teams in Universities (IRT1163)
Biodegradable poly（L-lactide-r-trimethene carbonate） copolymers （P（LLA-co-TMC）） with different compositions were synthesized. The degradation of the copolymers was carried out in phosphate buffer saline solutio...
关键词：COPOLYMER Poly（L-lactide-r-trimethene carbonate） DEGRADATION Crystallization. 
COMPARISON OF DRUG DELIVERY PROPERTIES OF PEG-b-PDHPC MICELLES WITH DIFFERENT COMPOSITIONS被引量：1
《Chinese Journal of Polymer Science》2012年第3期387-396,共10页顾忠伟 
financially supported by National Basic Research Program of China(National 973 program, No.2011CB606206);National Natural Science Foundation of China(NSFC,No.50830105);International collaboration project of Ministry of Science & Technology(MOST,No.2010DFA51550);Program for New Century Excellent Talents in Universities,Ministry of Education(MOE,NCET-10-0564)
An anti-tumor drug doxorubicin was encapsulated in micelles of poly（ethylene glycol）-b-poly（2,2-dihydroxyl- methyl propylene carbonate） （PEG-b-PDHPC） diblock copolymers. The morphololgy of both blank miceiles an...
关键词：Drug delivery Micelles DOXORUBICIN Biodegradable. 
INCLUSION COMPLEX FORMATION BETWEENα-CYCLODEXTRIN AND BIODEGRADABLE COMBLIKE COPOLYMERS WITH POLY(α,β-MALIC ACID) BACKBONES AND mPEG SIDE CHAINS
《Chinese Journal of Polymer Science》2009年第5期729-737,共9页何斌 顾忠伟 
supported by the National Basic Research Program of China(National 973 program,No2005CB623903);National Natural Science Foundation of China(No20604016);Sichuan Youth Science & Technology Foundation(No07ZQ026-013)
Inclusion complexes(ICs) composed ofα-cyclodextrins(α-CD) and biodegradable comblike copolymers with poly(α,β-malic acid)(PMA) backbones and methylated poly(ethylene glycol)(mPEG) side chains were prepared by the ...
关键词：Inclusion complexes α-Cyclodextrins Comblike copolymer. 
A NOVEL METHOD TO PREPARE CROSSLINKED POLYETHYLENEIMINE HOLLOW NANOSPHERES被引量：1
《Chinese Journal of Polymer Science》2007年第5期431-435,共5页何斌 顾忠伟 
This work was financially supported by the National Basic Research Program of China(National 973 program,No.2005 CB623903).
A novel method to prepare crosslinked polyethyleneimine （CPEI） hollow nanospheres was reported. Uniform silica nanospheres were used as templates, 3-aminopropyl trimethoxysilane （APS） was immobilized on the surfac...
关键词：Hollow nanospheres POLYETHYLENEIMINE TEMPLATE Crosslink. 
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