supported by the National Basic Research Program of China (No. 2004CB19604);the National Hi-Tech Development Program (No. 2007AA021305);the National Natural Science Foundation of China (No.30830006);the Project "Application of Nuclear Techniques in Agriculture" from the Chinese Ministry of Agriculture (No. 200803034) to YJH.
The MutT/Nudix superfamily proteins repair DNA damage and play a role in human health and disease. In this study, we examined two different cases of double MutT/Nudix domain-containing proteins from eukaryotes and pro...
the National Basic Research Program (Grant No. 2004CB19604);National Hi-Tech Development Program (Grant No. 2007AA021305);Distinguished Young Scientist (Grant No. 30425038);key project from the National Natural Science Foundation of China (Grant No. 30330020)
Based on a genetically modified radioresistant bacteria Deinococcus radiodurans, we constructed a real time whole cell biosensor to monitor radioactivity and genotoxicity in highly radioactive environ-ment. The enhanc...
Supported by the National Basic Research Program of China (Grant No. 2004CB19604);National Science Fund for Distinguished Young Scholars (Grant No. 30425038);Key Project from the National Natural Science Foundation of China (Grant No. 30330020)
In eukaryotes, the Mre11-Rad50-Nbs1 (MRN) complex, which resides at the crossroads of DNA repair and checkpoint signaling, rapidly forms prominent foci at damage sites following double-strand break (DSB) induction. Th...
the National Basic Research Program of China (Grant No. 2004 CB 19604);Grant for Distinguished Young Scientist of China (Grant No. 30425038);National Natural Science Foundation of China (Grant No. 30330020)
The functional analysis of dr1127,a novel gene in Deinococcus radiodurans was performed in this pa-per. The dr1127 gene was found occasionally in our microarray and 2-DE gel experiments. Mutation of the dr1127 gene de...
Supported by the National Basic Research Program of China (Grant No. 2004CB19604);the National Natural Science Foundation of China (Grant No. 30330020);the National Science fund for Distinguished Young Scholars (Grant No. 30425038)
The conclusion based on transmission electron microscopy, "the tightly packed ring-like nucleoid of the Deinococcus radiodurans R1 is a key to radioresistance", has instigated lots of debates. In this study, according...
Supported by the National Natural Science Foundation of China(Grant No.30330020),;National Basic Research Program of China(Grant No.2004CB19604);and the State Funds for Distinguished Young Scientists of China(Grant No.30425038)
LexA and RecA play a crucial role in SOS response in Escherichia coli.In classical SOS response,LexA functions as a repressor to regulate the expression of many genes including RecA after DNA damage occurs.Previous st...