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国家自然科学基金(30470767): 作品数：10被引量：13H指数：2; 导出分析报告; 相关作者：高金明费允云刘斌张文张奉春更多>>; 相关机构：北京协和医院青岛大学医学院附属医院更多>>; 相关期刊：《国际呼吸杂志》《Acta Pharmacologica Sinica》《中华风湿病学杂志》《Chinese Medical Sciences Journal》更多>>; 相关主题：CXCR3CXCL10SHORT-TERM肝硬化模型趋化因子受体3更多>>; 相关领域：医药卫生生物学农业科学轻工技术与工程更多>>

Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus被引量：1: 《Acta Pharmacologica Sinica》2011年第8期1038-1044,共7页Zhen-jia LIU Yan-juan YANG Lei JIANG Ying-chun XU Ai-xia WANG Guan-hua DU Jin-ming GAO; Acknowledgements This work was in part supported by grants from National Natural Science Foundation of China （No 30470767）, Beijing Natural Sciences Foundation （No 7072063）, Education Ministry of China New Century Excellent Talent （NCET 06-0156） and Janssen Research Council China （All grants were to Jin- ming GAO）. We are grateful for Dr Hyeryun CHOE＇s helpful encouragement and for providing the plasmids. We thank Prof Wen- hui LI for kind help in designing the primers. We particularly thank Prof Kian Fan CHUNG for his helpful suggestions, discussion, and excellent English editing of the text.; Aim： Staphylococcus auteus evades host defense through releasing several virulence proteins, such as chemotaxis inhibitory protein of staphylococcus aureus （CHIPS）. It has been shown that extracellular N terminus o...; 关键词：Staphylococcus aureus chemotaxis inhibitory protein tyrosine sulfation post-translational modification chemotactic receptor C5aR

敲除趋化因子受体3对延缓原发性胆汁性肝硬化模型病情进展的作用被引量：1: 《中华风湿病学杂志》2011年第3期147-150,217,共5页费允云张文高金明刘斌张奉春; 基金项目：国家自然科学基金（30470767）;国家“十一五”科技支撑计划（2008BAl59803）; 目的建立原发性胆汁性肝硬化（PBC）动物模型，研究趋化因子受体3（CXCR3）及其配体干扰素诱导蛋白10（CXCLIO）在PBC发病中的作用。方法6~8周雌性C57BL／6J小鼠72只，分为3组：C57BL／6J野生鼠PBC模型组、正常对照组、CXCR3基因敲除（C...; 关键词：肝硬化胆汁性受体趋化因子干扰素诱导蛋白10 CXCR3基因敲除小鼠

Toll样受体3介导的信号通路在原发性胆汁性肝硬化模型中的作用被引量：1: 《中华临床免疫和变态反应杂志》2011年第1期5-9,83,共6页费允云张文高金明刘斌张奉春; 国家十一五科技支撑计划(2008BAI59B03);国家自然科学基金(30470767); 目的初步探索Toll样受体3(TLR3)介导的信号通路在原发性胆汁性肝硬化(PBC)发病中的作用以及趋化因子受体3(CXCR3)对其影响。方法 6～8周雌性C57BL/6野生鼠和CXCR3基因敲除(CXCR3-/-)鼠,腹腔注射5mg/kg的聚肌胞(poly I:C),每周2次,第8、1...; 关键词：原发性胆汁性肝硬化趋化因子受体3 TOLL样受体3 TIR区域的调节分子1 核因子κB

Chemokine receptor CXCR3 is important for lung tissue damage and airway remodeling induced by short-term exposure to cigarette smoking in mice被引量：3: 《Acta Pharmacologica Sinica》2010年第4期436-442,共7页Li NIE Zhen-jia LIU Wei-xun ZHOU Ruo-lan XIANG Yu XIAO Bao LU Bao-sen PANG Jin-ming GAO; Aim： To investigate the role of chemokine receptor CXCR 3 in cigarette smoking （CS）-induced pulmonary damage. Methods： CXCR3 knockout （CXCR3-/-） mice were used. Differences in airspace enlargement, mRNA expressi...; 关键词：CXCR3 CXCL10 cigarette smoking tissue damage airway remodeling

Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10被引量：2: 《Acta Pharmacologica Sinica》2009年第2期193-201,共9页Jin-ming GAO Ruo-lan XIANG Lei JIANG Wen-hui LI Qi-ping FENG Zi-jiang GUO Qi SUN Zheng-pei ZENG Fu-de FANG; Acknowledgements This work was supported in part by grants from the National Natural Science Foundation of China （No 30470767）, the Beijing Natural Science Foundation （No 7072063）, and the Ministry of Education of China （No NCET 06-0156）. We are grateful to Dr Hyeryun CHOE for helpful encouragement and plasmids, Dr Paulette L WRIGHT for critical reading and editing of this manuscript, Drs Wei CUI and Ding-hua LIU for assistance with FACS analysis and Dr Zhi-ying ZHAO for help in performing binding experiments.; Aim： Human CXCR3, a seven-transmembrane segment （7TMS）, is predominantly expressed in Th1-mediated responses. Interferon-y-inducible protein 10 （IP-10） is an important ligand for CXCR3. Their interaction is pivot...; 关键词：TYROSINE SULFATION chemokine receptor interferon y-inducible protein 10 CXCR3

Acute pulmonary inflammation is inhibited in CXCR3 knockout mice after short-term cigarette smoke exposure被引量：6: 《Acta Pharmacologica Sinica》2008年第12期1432-1439,共8页Li NIE Ruo-lan XIANG Yong LIU Wei-xun ZHOU Lei JIANG Bao LU Bao-sen PANG De-yun CHENG Jin-ming GAO; This work was supported by grants from the National Natural Science Foundation of China （No 30470767）, Beijing Natural Science Foundation （No 7072063）, and the Education Ministry of China Grant （NCET 06-0156）.Acknowledgements We are grateful to Prof Craig GERARD （Harvard Medical School, Boston, USA） who provided the CXCR3 knockout mice, the staff of the Animal Center-PUMC （Beijing, China） for caring for the animals, and particularly, Hui-min ZHAO. We gratefully acknowledge Prof Richard E RUFFIN and Prof Surendral K BANSAL for critically reading this manuscript and for their helpful suggestions. We also would like to express our thanks to Prof Klan Fan CHUNG for his helpful comments and excellent editing of the manuscript.; Aim： CXCR3, via binding its specific ligand CXCL10, plays an important role in cigarette smoke （CS）-induced pulmonary inflammation. CXCR3 is preferentially expressed in activated T cells （chiefly CD8^＋ T cells）....; 关键词：CXCR3 CD8 CXCL10 cigarette smoke

γδT细胞与支气管哮喘: 《国际呼吸杂志》2008年第21期1317-1320,共4页刘泽宇高金明郭子建; 国家自然科学基金资助项目（30470768,30470767）; γδT细胞是一种在肺部含量较多的T细胞亚群。在发育、分布、表面标志和抗原识别等方面，都具有不同于αβT细胞的特性。支气管哮喘（简称哮喘）个体肺部γδT细胞的比例较健康人明显升高。在哮喘发病的不同阶段，不同的γδT细胞亚群...; 关键词：ΓΔT细胞支气管哮喘免疫调节

支气管相关淋巴组织研究进展被引量：1: 《国际呼吸杂志》2008年第6期364-367,共4页陈华夏高金明郭子建; 国家自然科学基金项目（30470768、30470767）; 支气管相关淋巴组织（bronchus—associated lymphoid tissue，BALT）是支气管内能够对吸入的抗原发生B细胞和T细胞免疫应答的淋巴细胞集合体。大部分BALT位于人或动物支气管分叉处，具有相对特异的组织特征。BALT从胎儿期即开始出现，...; 关键词：支气管相关淋巴组织免疫应答淋巴瘤

COPD遗传学研究现状和问题: 《中国实用内科杂志：临床前沿版》2006年第9期1380-1383,共4页高金明; 国家自然科学基金(30470767); 关键词：COPD患者遗传学 PULMONARY 慢性阻塞性肺疾病 DISEASE 吸烟者相互作用环境因素

CXC CHEMOKINE RECEPTOR 3 MODULATES BLEOMYCIN-INDUCED PULMONARY INJURY VIA INVOLVING INFLAMMATORY PROCESS: 《Chinese Medical Sciences Journal》2006年第3期152-156,共5页Jin-ming Gao Bao Lu Zi-jian Guo; Supported by the National Natural Sciences Foundation of China(30470767,30470768); Objeelive To investigate the role of CXC chemokine receptor 3 （ CXCR3 ） in bleomycin-induced lung injury by using CXCR3 gene deficient mice. Methods Sex-, age-, and weight-matched C57BL/6 CXCR3 gene knockout mice an...; 关键词：chemokine receptor BLEOMYCIN lung injury INFLAMMATION

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