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国家自然科学基金(30570864): 作品数：11被引量：14H指数：2; 导出分析报告; 相关作者：杨红侯婷婷葛红孙娟娟于波更多>>; 相关机构：辽宁师范大学东北师范大学吉林大学中日联谊医院吉林大学更多>>; 相关期刊：《吉林大学学报（医学版）》《药学学报》《Chemical Research in Chinese Universities》《高等学校化学学报》更多>>; 相关主题：激活剂氯离子通道ACTIVATORCFTR突变更多>>; 相关领域：医药卫生生物学理学轻工技术与工程更多>>

Aquaporin-3 Deletion Reduces Glycerol and ATP Content in Mouse Sciatic Nerve被引量：2: 《Chemical Research in Chinese Universities》2010年第6期955-957,共3页ZHANG Di GUO Lei ZHU Na SU Wei-heng GUAN Xin-gang YI Fei HAO Feng XIAO Ying-hong LIU Jia LIU Tian-zhou MA Tong-hui; Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405,30570864,30670477 and 30770493)and the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011); We reported the expression and function of aquaglyceroporin AQP3 in mouse peripheral nervous system.AQP3 mRNA was identified in freshly isolated mouse sciatic nerve by RT-PCR.Immunofluorescence using AQP3 antibody loc...; 关键词：AQUAPORIN Sciatic nerve myelin GLYCEROL ATP

Remarkably Decreased CD11b Positive Splenocytes in Aquaporin 3-Null Mice: 《Chemical Research in Chinese Universities》2010年第2期217-220,共4页ZHU Na QIAO Ying ZHANG Di WANG Wen-juan LIU Jia LIU Tian-zhou MA Tong-hui; Supported by the National Basic Research Program of China(No.2009CB521908);the National Natural Science Foundation of China(Nos.30470405, 30570864,30670477 and 30770493);the National Natural Science Fund for Distinguished Young Scholars of China(No.30325011); Aquaporins（AQPs） are molecular water channels that play important physiological roles in fluid trans-porting organs. The expression and function of AQPs in the immune system are largely unknown. CD 11 （a-d）/CD18 i...; 关键词：AQUAPORIN SPLENOCYTE CD1 lb Flow cytometry

对羟基苯甲酸丁酯激活囊性纤维化跨膜电导调节因子氯离子通道开放被引量：1: 《药学学报》2009年第1期32-37,共6页葛红侯婷婷孙娟娟杨红; 国家自然科学基金资助项目(30570864);教育部"新世纪优秀人才支持计划"项目(NCET-07-0406);辽宁省"高等学校优秀人才支持计划"项目(2006R33); 对20种挥发油类化合物中的对羟基苯甲酸丁酯(butyl-p-hydroxybenzoate,Bpb)的CFTR氯离子通道激活作用进行系统的分子药理学研究。利用稳定共表达人CFTR和对卤族元素碘离子高度敏感的荧光绿蛋白突变体(EYFP)的Fischer大鼠甲状腺(FRT)上...; 关键词：CFTR氯离子通道突变对羟基苯甲酸丁酯激活剂

丹皮酚对囊性纤维化跨膜电导调节因子氯离子通道的激活作用被引量：1: 《中国临床药理学与治疗学》2008年第11期1208-1213,共6页侯婷婷葛红孙娟娟于波杨红; 国家自然科学基金项目(30570864);教育部"新世纪优秀人才支持计划"项目(NCET-07-0406);辽宁省"高等学校优秀人才支持计划"项目(2006R33); 目的:研究丹皮酚对依赖于3’,5’-环腺苷酸(cAMP)的囊性纤维化跨膜电导调节因子(CFTR)Cl-通道的激活作用。方法:利用Cl-通道细胞荧光测定模型进行测定丹皮酚对CFTR介导的I-内流速度。结果:丹皮酚对野生型和ΔF508突变型CFTR Cl-通道均...; 关键词：丹皮酚囊性纤维化跨膜电导调节因子高血压 Cl^-转运激活剂

黄芩素对人野生型CFTR氯离子通道的激活作用被引量：2: 《吉林大学学报（医学版）》2008年第3期397-400,共4页周娜侯婷婷葛红孙娟娟徐丽娜; 国家自然科学基金资助课题(30570864); 目的:研究天然黄酮类化合物黄芩素对囊性纤维化跨膜电导调节因子(CFTR)氯离子通道的激活作用。方法:利用稳定共表达人CFTR与一种对卤族元素敏感的荧光绿蛋白突变体(EYFP-H148Q)的FRT细胞模型,测定黄芩素(0.18、0.55、1.65、5、15、44、...; 关键词：野生型CFTR CI-转运黄芩素激活剂

20(S)-原人参二醇促进CFTR氯离子通道开放被引量：6: 《高等学校化学学报》2008年第4期731-735,共5页刘军那万里辛伟红刘丽丹于波麻彤辉杨红; 国家自然科学基金(批准号:30470405,30570864,30670477);吉林省杰出青年基金(批准号:20030112);教育部青年骨干教师奖励计划;留学回国人员科研基金资助; 利用氯离子通道细胞荧光测定模型对386种中药单体化合物进行筛选,发现20(S)-原人参二醇对依赖于cAMP的CFTR氯离子通道具有激活作用.20(S)-原人参二醇能够以剂量依赖的方式激活野生型CFTR氯离子通道,其激活作用通过更为可靠的氯离子通道...; 关键词：囊性纤维化 CFTR氯离子通道突变天然化合物激活剂

Activation of CFTR-mediated Cl^- Transport by Magnolin: 《Chemical Research in Chinese Universities》2008年第2期187-191,共5页JIN Ling-ling LIU Xin SUN Yan LIN Sen ZHOU Na XU Li-na YU Bo HOU Shu-guang YANG Hong; Supported by the National Natural Science Foundation of China(Nos30470405 and 30570864); Magnolin is a herbal compound from Magnolia biondii Pamp. It possesses numerous biological activities. Cystic fibrosis transmembrane conductance regulator（CFTR） is an epithelial chloride channel that plays a key rol...; 关键词：Cystic fibrosis CFTR MUTATION Magnolin ACTIVATOR

Natural Compound Curcumin Corrects the Gating Defect of G551DMutant Cystic Fibrosis Transmembrane Conductance Regulator: 《Chemical Research in Chinese Universities》2008年第1期92-95,共4页HAO Li-ming LIU Xin XU Li-na ZHU Na LIN Sen HOU Shu-guang ZHOU Na SHI De-cheng SHANG De-jing MA Tong-hui YANG Hong; National Natural Science Fund for Distinguished Young Scholars(No.30325011);National Natural Science Foundation of China(Nos.30470405, 30570864, 30670477);Distinguished Young Scholars Fund of Jilin Province (No.20030112) ;Excellent Young Teachers Program of Ministry of Education, China; In the present study, we identified the natural compound curcumin to be an effective G551D-CFTR activator by cell-based fluorescent assay and electrophysiological measurement. We demonstrated that curcumin can restore...; 关键词：Cystic fibrosis CFTR MUTATION Natural compound ACTIVATOR

Dictamine Stimulates Cystic Fibrosis Transmembrane Conductance Regulator Cl-Transport被引量：2: 《Chemical Research in Chinese Universities》2007年第5期554-557,共4页LIU Jun LIU Li-dan WANG Su-mei XU Li-na YU Bo LIN Sen; Supported by the National Natural Science Foundation of China(Nos.30470405and30570864).; Dictamine is a furoquinoline alkaloid isolated from Dictamus dasycarpus Turcz.In the present study,we found that dictamine is able to stimulate the chloride transport activity of wild-type and ΔF508 mutant CFTR.The a...; 关键词：Cystic fibrosis CFI＇R Dictamine ACTIVATOR

Activation Effect of Cathartic Natural Compound Rhein to CFTR Chloride Channel: 《Chemical Research in Chinese Universities》2006年第3期312-314,共3页SHI Lin-lin XU Li-na HOU Shu-guang LIN Sen YANG Hong MA Tong-hui; SupportedbytheNationalNaturalScienceFundforDistinguishedYoungScholars(No.30325011),theNationalNaturalScienceFoundationofChina(Nos.30470405and30570864),DistinguishedYoungScholarsFundofJilinProvince(No.20030112),andExcellentYoungTeachersProgramofMOE,China.; The cystic fibrosis transmembrane conductance regulator （CFFR） is a cAMP-activated chloride channel expressed in intestinal exoerine glands, which plays a key role in intestinal fluid secretion. A natural anthraquin...; 关键词：CFTR chloride channel ANTHRAQUINONE Laxative drug

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