《Genes & Diseases》

作品数：1329被引量：2457H指数：20
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《Genes & Diseases》
主办单位：Chongqing Medical University
最新期次：2025年2期更多>>
发文主题：CANCERMETABOLISMMETASTASISPROMOTESHEPATOCELLULAR_CARCINOMA更多>>
发文领域：医药卫生生物学文化科学理学更多>>
发文基金：国家自然科学基金重庆市自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>
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Triplet therapy overcomes 3rd-EGFR TKl-resistant EGFR-L858R/T790M/C797S in trans and in cis/L718Q mutation
《Genes & Diseases》2025年第2期1-3,共3页Kaibo Ding Zhongsheng Peng Yanjun Xu 
supported by the Natural Scientific Foundation of Zhejiang Province,China (No.LTGY23H160007).
Epidermal growth factor receptor(EGFR)-positive nonsmall cell lung cancer is a dynamic entity,with tumor progression and resistance to tyrosine kinase inhibitors(TKls)stemming from the accumulation of mutations over t...
关键词：heterogeneity. LUNG OVERCOME 
Unique presentation of a novel gain-of-function mutation in MTOR
《Genes & Diseases》2025年第2期4-6,共3页Samira Slimani Alex G.I.Gagnon Simon V.Schreiber Nicolas A.D.Bergeron Ludwig Haydock Sebastien Labonte Marc-Etienne Huot Alexandre P.Garneau Paul Isenring 
Smith-Kingsmore syndrome(SKS)is a very rare dominantly inherited disorder caused by a gain-of-function mutation in MTOR(mechanistic target of rapamycin).1,2 It is typically characterized by megalencephaly,developmenta...
关键词：FACIAL FUNCTION typically 
A novel metabolite-interacting protein(MIP)-based molecular subtyping construction and validation of IGFBP3 as a MiP-related oncogene in colorectal cancer
《Genes & Diseases》2025年第2期7-10,共4页Simeng Bao Yongmin Li Yu Liang Jianxun Dai Huolin Huang Bin Ma 
supported by grants from the Cultivation Program of National Science Foundation of Liaoning Cancer Hospital (China) (No.2021-ZLLH-03);Beijing Xisike Clinical Oncology Research Foundation (China) (No.Y-QL202101-0039);Medical and Industrial Cross Joint Fund of Dalian University of Technology-Liaoning Cancer Hospital (China) (No.LD2023027);The National Natural Science Foundation of China (No.82303131);the Liaoning Province Science and Technology Plan Joint Program (Applied Basic Research Project) (China) (No.2023JH2/101700150).
For prognosis and therapeutic response,colorectal cancer(CRC)patients are highly variable across stages,correlated to high inter-tumor heterogeneity at the molecular level.1 Therefore,molecular subtyping needs to be d...
关键词：colorectal cancer IGFBP3 
The important role and core marker gene of tumor-infiltrating plasma cells in the microenvironment of lung adenocarcinoma
《Genes & Diseases》2025年第2期11-14,共4页Jianhong Zhang Chengyang Song Xiuqin Feng QianYu Xueying Yang 
supported by the support for High-quality Development of Scientific Research Funding Project of China Medical University (No.2023JH2/20200137).
Lung adenocarcinoma(LUAD)is the primary subtype of lung cancer,but its prognosis remains challenging.The tumor microenvironment plays a central role in the initiation and development of tumors,particularly regarding t...
关键词：ADENOCARCINOMA LUNG PROGNOSIS 
Predicting anti-cancer drug sensitivity through WRE-XGBoost algorithm with weighted feature selection
《Genes & Diseases》2025年第2期15-17,共3页Yiyao Jiang Ming Chen Zhongmin Xiong Yufang Qin 
supported in part by the Shanghai Science and Technology Innovation Action Planning (No.20dz1203800 to M.C.);the Research and Development Planning in Key Areas of Guangdong Province,China (No.2021 B0202070001 to M.C.);the National Natural Sci-ence Foundation of China (No.61702325 to Y.Q.).
Accurate prediction of drug susceptibility is one of themost important steps in personalized medicine.Applications of machine learning to pharmacogenomic data for sensitivity prediction can help study the mechanism of...
关键词：STEPS SUSCEPTIBILITY ALGORITHM 
Reduction of Atp5b protects mice from diet-induced obesity
《Genes & Diseases》2025年第2期18-20,共3页Xiaohua Huang Binting Qin Zhengfeng Fang Lianqiang Che Yan Lin Shengyu Xu Yong Zhuo Lun Hua Xuemei Jiang Mengmeng Sun Hairui Wang De Wu Qingqiang Long Bin Feng 
supported by the National Natural Science Foundation of China (No.32272893);the Program of the Giant Panda Breeding Research Foundation (China) (No.2020CPB-C10).
Obesity related metabolic diseases,including non-alcoholic fatty liver disease,insulin resistance,hyperglycemia,and hyperlipemia,have become major chronic diseases.i,2 As an important enzyme for ATP production,3 ATP5b...
关键词：HOMEOSTASIS metabolism. proliferation. 
Transcriptional programs associated with luminal play a vital role in invasive mucinous lung adenocarcinoma
《Genes & Diseases》2025年第2期21-24,共4页Shufan Zhang Rong Jiang Changguo Wang Manqiu Yang Tao Wang Jianzhou Cui Guangbin Li Shaomu Chen Moli Huang 
supported by the National Natural Science Foundation of China (No.32370598,31971117);the National Key R&D Program of China (No.2018YFA0801100);the Natural Science Foundation of Suzhou,Jiangsu,China (No.SYS201517);the Priority Academic Program Development of Jiangsu Higher Education Institutions (China)。
Invasive mucinous lung adenocarcinoma(IMAi)san aggressive subtype characterized by the presence of tumor cells with goblet cell morphology and abundant intracytoplasmic mucin.A previous study had shown that all epithe...
关键词：ADENOCARCINOMA LUMINAL MUCINOUS 
Expanding the spectrum of novel candidate genes using trio exome sequencing and identification of monogenic cause in 27.5%of 320 families with steroid-resistant nephrotic syndrome
《Genes & Diseases》2025年第2期25-28,共4页Ronen Schneider Shirlee Shril Florian Buerger Konstantin Deutsch Kirollos Yousef Camille N.Frank Ana C.Onuchic-Whitford Thomas M.Kitzler Youying Mao Verena Klambt Muhammad Y.Zahoor Katharina Lemberg Amar J.Majmundar Bshara Mansour Ken Saida Steve Seltzsam Caroline M.Kolvenbach Lea Maria Merz Nils D.Mertens Tobias Hermle Nina Mann Dalia Pantel Abdul A.Halawi Aaron Bao Luca Schierbaum Sophia Schneider Daanya Salmanullah Iddo Z.Ben Dov Itamar Sagiv Loai A.Eid Hazem Subhi H.Awad Muna Al Saffar Neveen A.Soliman Marwa M.Nabhan Jameela A.Kari Sherif El Desoky Mohamed A.Shalaby Said Ooda Hanan M.Fathy Shrikant Mane Richard P.Lifton Michael J.G.Somers Friedhelm Hildebrandt 
supported by grants from the National Institutes of Health (NIH) (No.5R01DK076683-13,RC2-DK122397 to F.H.);Sequencing and data processing were performed by the Yale Centers for Mendelian Genomics funded by the National Human Genome Research Institute (No.U54 HG006504);supported by the Office of Faculty Development.K.Y.,C.N.F.,and N.D.M.are supported by an NIH Training Grant (No.5T32DK007726);by the 2017 Post-doctoral Fellowship Grant from the Harvard Stem Cell Institute.A.C.O.acknowledges support from the National Institutes of Health F32 Ruth L.Kirschstein Postdoctoral Individual National Research Service Award (No.DK122766);supported by a Post-Doctoral Fellowship award from the KRESCENT Program,a national kidney research training partnership of the Kidney Foundation of Canada,the Canadian Society of Nephrology,and the Canadian Institutes of Health Research.V.K.is funded by the Deutsche Forschungsgemeinschaft grant (No.403877094);supported by a Fulbright Scholar fellowship (USEFP).K.L.is funded by the Deutsche Forschungsgemeinschaft Research Foundation (No.DFG461126211);supported by the NIH (No.5K12HD052896-13,1K08DK125768-01A1);American Society of Nephrology Norman Siegel Research Scholar Grant,and Manton Center for Orphan Disease Research;supported by the Deutsche Forschungsgemeinschaft (German Research Foundation,No.442070894);supported by a grant from the Deutsche Forschungsgemeinschaft (German Research Foundation,No.KO 6579/2-1);supported by funding from the National Institutes of Health (No.K08-DK127011);supported by the Jiang-Li Family Foundation.
Steroid-resistant nephrotic syndrome(SRNS)is a leading cause of pediatric end-stage renal disease.Monogenic causes have been detected in 11%-45%of pediatric SRNS using exome sequencing,1-3 leaving a large proportion o...
关键词：PEDIATRIC nephrotic RESISTANT 
Actin polymerization regulates the osteogenesis of hAsCs by influencingα-tubulin expression and Eg5 activity
《Genes & Diseases》2025年第2期29-32,共4页Tingyu Fan Wenqing Liu Rongmei Qu Jinhui Zhu Yulian Shi Jiaxuan Liu Xiangtian Li Zhitao Zhou Yunbing Chang Jun Ouyang Jingxing Daia 
supported by the National Key R&D Program of China (No.2022YFF1202603);the President's Foundation of TCM-Integrated Hospital of Southern Medical University (No.1202103001).
Seed cells,scaffold materials,and growth factors constitute the three fundamental components of bone tissue engineering.In recent years,human adipose-derived stem cells(hASCs)have emerged as promising candidate cells ...
关键词：Eg5 engineering. CONSTITUTE 
NOP56 promotes hepatocellular carcinoma progression through 2'-O-methylation
《Genes & Diseases》2025年第2期33-36,共4页Shuxin Yang Juan Liu Shengxin Luo Wentao Wang Jingxiang Xu 
funded by the High-level Talent Research Funds of Gannan Medical University (No.QD202122).
Hepatocellular carcinoma(HCC)is a common malignant tumor and one of the leading causes of cancer-related deaths,with the fourth-highest incidence rate and the second-highest mortality rate in China.1 Currently,HCC is ...
关键词：MORTALITY CHEMOTHERAPY surgery 
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