《Cancer Pathogenesis and Therapy》

作品数：82被引量：24H指数：3
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《Cancer Pathogenesis and Therapy》
主办单位：中华医学会
最新期次：2024年4期更多>>
发文主题：PATIENTSIMMUNOTHERAPYCANCERPROGNOSISMULTIPLE_MYELOMA更多>>
发文领域：医药卫生文化科学更多>>
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New insights into digestive tract tumors
《Cancer Pathogenesis and Therapy》2024年第4期217-218,共2页Zhidong Gao Zhanlong Shen Shuo Wang Yingjiang Ye 
the Beijing Xisike Clinical Oncology Research Foundation(No.Y-xsk2021-0004).
Digestive tract tumors,ranging from esophageal to colorectal cancers(CRCs),pose a substantial challenge in oncology because of their high global incidence and mortality.1,2 The heterogeneity of these malignancies unde...
关键词：Digestive tract tumors TGF-Β SDC2 IMMUNOTHERAPY SNHG8 
Co-culture models for investigating cellular crosstalk in the glioma microenvironment
《Cancer Pathogenesis and Therapy》2024年第4期219-230,共12页Xiaodong Niu Yan Zhang Yuan Wang 
Glioma is the most prevalent primary malignant tumor in the central nervous system(CNS).It represents a diverse group of brain malignancies characterized by the presence of various cancer cell types as well as an arra...
关键词：GLIOMA Coculture techniques Tumor microenvironment 
Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions
《Cancer Pathogenesis and Therapy》2024年第4期231-245,共15页Md.Liakot Ali Amdad Hossain Roky S.M.Asadul Karim Azad Abdul Halim Shaikat Jannatul Naima Meem Emtiajul Hoque Abu Mohammed Fuad Ahasan Mohammed Murshedul Islam Md.Saifur Rahaman Arif Md.Saqline Mostaq Md.Zihad Mahmud Mohammad Nurul Amin MdAshiq Mahmud 
Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing incidence.Autophagy,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimen...
关键词：AUTOPHAGY Skin cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds Synthetic compounds 
Role of indoleamine 2,3-dioxygenase 1 in immunosuppression of breast cancer
《Cancer Pathogenesis and Therapy》2024年第4期246-255,共10页Pratyasha Sarangi 
Breast cancer(BC)contributes greatly to global cancer incidence and is the main cause of cancer-related deaths among women globally.It is a complex disease characterized by numerous subtypes with distinct clinical man...
关键词：IDO1 Breast cancer IDO1 inhibitor IMMUNOSUPPRESSION Tumor microenvironment 
Intraoperative glioblastoma surgery-current challenges and clinical trials:An update
《Cancer Pathogenesis and Therapy》2024年第4期256-267,共12页Vimal Patel Vishal Chavda 
Surgical excision is an important part of the multimodal therapy strategy for patients with glioblastoma,a very aggressive and invasive brain tumor.While major advances in surgical methods and technology have been acc...
关键词：GLIOBLASTOMA Infiltrative tumor Awake craniotomy Evoked potentials NEUROIMAGING Navigation 
Efficacy and safety of anlotinib plus penpulimab as second-line treatment for small cell lung cancer:A multicenter,open-label,single-arm phase Ⅱ trial
《Cancer Pathogenesis and Therapy》2024年第4期268-275,共8页Changgong Zhang Jianhua Chen Huijuan Wu Jun Wang Liying Gao Jun Zhao Yan Sun Zhongyao Jia Xinlin Mu Chunmei Bai Rui Wang Kailiang Wu Qiang Liu Yuankai Shi 
supported by the National Science and Technology Major Project for Key New Drug Development(No.2017ZX09304015).
Background:Currently,the need for new therapeutic strategies involving programmed cell death protein-1(PD-1)monoclonal antibodies in the second-line setting of small cell lung cancer(SCLC)is urgent.This study aimed to...
关键词：Anlotinib Penpulimab Small cell lung cancer EFFICACY Safety PhaseⅡtrial 
Efficacy and toxicity of anlotinib plus camrelizumab versus anlotinib plus S-1 as second-line therapy for advanced esophageal squamous cell carcinoma:A real-world retrospective study
《Cancer Pathogenesis and Therapy》2024年第4期276-284,共9页Wei Zhang Mingyu Chen Hong Dai Wei Sun 
the Wu Jieping Medical Foundation(No.320.6750).
Background:No data exist on the efficacy and safety of anlotinib plus camrelizumab doublet as second-line therapy for advanced esophageal squamous cell carcinoma(ESCC).Although anlotinib and the programmed death-1(PD1...
关键词：Anlotinib Camrelizumab Esophageal squamous cell carcinoma Progression-free survival TOXICITY Retrospective study 
Incidence rate and risk factors of second primary neoplasms among older patients with hematological malignancies:Insights from a Chinese single-center experience(1997-2021)
《Cancer Pathogenesis and Therapy》2024年第4期285-291,共7页Yadi Zhong Bing Zhai Jing Zeng Bo Yang Bo Guo Xuechun Lu 
supported by the National Key Research and Development Plan of China(No.2020YFC2002706-2);the National Clinical Research Center for Geriatrics of China Open Project(No.NCRCGPLAGH-2022011).
Background:Patients with hematological malignancies face an increased risk of developing second primary neoplasms due to various factors,including immune system compromise and chemotherapy-related effects.However,the ...
关键词：Hematological malignancies Second primary neoplasms OLDER INCIDENCE Risk factors 
Association between autoimmunity-related disorders and prostate cancer:A Mendelian randomization study
《Cancer Pathogenesis and Therapy》2024年第4期292-298,共7页Peixian Chen Yue Wang Zhi Xiong Tianlong Luo Yiming Lai Haitao Zhong Shirong Peng Ruilin Zhuang Kaiwen Li Hai Huang 
supported by the National Key R&D Plan of China(No.2022YFC3602904);the National Natural Science Foundation of China(No.81974395,No.82173036,and No.82173088);Key R&D Plan of Guangdong Province(No.2023B1111030006 and No.202206010117);the Guangdong Province Natural Science Foundation(No.2022A1515012497and No.2022A1515012383);the Science and Technology Planning Project of Guangdong Province(No.2023B1212060013);Guangdong Provincial Clinical Research Center for Urological Diseases(No.2020B1111170006);the Guangzhou Science and Technology Fund(No.A202201011299);International Science and Technology Cooperation Project Plan of Guangdong Province(No.2021A0505030085);Sun Yat-Sen University Clinical Research 5010 Program(No.2019005);Beijing Bethune Charitable Foundation(No.mnzl202001);Beijing Xisike Clinical Oncology Research Foundation(No.Y-MSDZD2022-0760 and No.Y-tongshu2021/ms-0162);open research funds from the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital。
Background:Although many epidemiological studies and meta-analyses have reported an association between autoimmune disorders and prostate cancer,none has reported a clear correlation or the direction of the associatio...
关键词：Prostate cancer Autoimmunity-related diseases Potential relationship Mendelian randomization 
Transforming growth factor-β(TGF-β)signaling pathway-related genes in predicting the prognosis of colon cancer and guiding immunotherapy
《Cancer Pathogenesis and Therapy》2024年第4期299-313,共15页Jie Chen Chao Ji Silin Liu Jin Wang Che Wang Jue Pan Jinyu Qiao Yu Liang Mengjiao Cai Jinlu Ma 
supported by grants from the Scientific Development Funding of the First Affiliated Hospital of Xi'an Jiaotong University(No.YXJLRH2022039 and No.2020QN-07);the Fundamental Research Funds for the Central Universities(No.xzy012020044);the Open Research Fund of Hubei Key Laboratory of Precision Radiation Oncolog(No.jzfs021).
Background:Colon cancer is a malignant tumor with high malignancy and a low survival rate whose heterogeneity limits systemic immunotherapy.Transforming growth factor-β(TGF-β)signaling pathway-related genes are asso...
关键词：Colon cancer PROGNOSIS Risk signature Immune microenvironment IMMUNOTHERAPY 
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