《Cancer Pathogenesis and Therapy》

作品数：106被引量：25H指数：3
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《Cancer Pathogenesis and Therapy》
主办单位：中华医学会
最新期次：2025年2期更多>>
发文主题：CANCERPATIENTSIMMUNOTHERAPYPROGNOSISMULTIPLE_MYELOMA更多>>
发文领域：医药卫生文化科学更多>>
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Cardiotoxicity in platinum-based chemotherapy:Mechanisms,manifestations,and management
《Cancer Pathogenesis and Therapy》2025年第2期101-108,共8页Bety Rachma Merlyna Savitri Henry Sutanto 
Platinum-based chemotherapy,a cornerstone in the treatment of various malignancies,is often limited by its potential cardiotoxic effects.Understanding these effects is crucial for optimizing patient outcomes and guidi...
关键词：Cardiotoxic agents CHEMOTHERAPY PLATINUM Cancer Cardiovascular disease ONCOLOGY 
Exploring the significance of extracellular vesicles:Key players in advancing cancer and possible theranostic tools
《Cancer Pathogenesis and Therapy》2025年第2期109-119,共11页Bhaumik Patel Shreyas Gaikwad Sahdeo Prasad 
Metastasis remains a critical challenge in cancer treatment and the leading cause of cancer-related mortality.Ongoing research has demonstrated the key role of extracellular vesicles(EVs)in facilitating communication ...
关键词：Extracellular vesicle(EV) Cancer metastasis BIOMARKER Bioengineered EV 
Dynamics of epithelial-mesenchymal plasticity driving cancer drug resistance
《Cancer Pathogenesis and Therapy》2025年第2期120-128,共9页Rashmi Bangarh Reena V.Saini Adesh K.Saini Tejveer Singh Hemant Joshi Seema Ramniwas Moyad Shahwan Hardeep Singh Tuli 
supported by the DST-INSPIRE(Department of Science&Technology-Innovation in Science Pursuit for Inspired Research)Fellowship(No.IF210078);the Department of Science and Technology(Technology Development Program),Government of India(No.TDP/BDTD/54/2021/General);the Indian Council of Medical Research-Department of Health Research(ICMR-DHR)Young Scientist Fellowship(F.No:R.12014/29/2022/HR).
Epithelial-mesenchymal transition(EMT)promotes several cancers by increasing tumor cell motility,disrupting epithelial cell phenotypes,apical-basal polarity,and intracellular connections,and enhancing tumor resistance...
关键词：Epithelial-mesenchymal transition Tumor microenvironment METASTASIS Cancer drug resistance 
Risk of autoimmunity,cancer seeding,and adverse events in human trials of whole-tissue autologous therapeutic vaccines
《Cancer Pathogenesis and Therapy》2025年第2期129-134,共6页Garret Gianneschi Anthony Scolpino James Oleske 
Background:Whole-tissue autologous therapeutic vaccines(WATVs)are a form of cancer immunotherapy that use a patient's own pathological tissue.Concerns exist regarding the potential of WATVs to induce autoimmunity or t...
关键词：NEOPLASMS VACCINATION AUTOIMMUNITY IMMUNOTHERAPY Drug-related side effects and adverse reactions Systematic review Cancer vaccines 
A Bayesian network meta-analysis of EGFR-tyrosine kinase inhibitor treatments in patients with EGFR mutation-positive non-small cell lung cancer☆
《Cancer Pathogenesis and Therapy》2025年第2期135-146,共12页Jianqiong Yin Jing Huang Min Ren Rui Tang Linshen Xie Jianxin Xue 
supported by the National Natural Science Foundation of China(No.82373021);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYYC23010);the Natural Science Foundation of Science and Technology Department of Sichuan Province(No.2023ZYD0094);the National Clinical Research Center for Geriatrics(No.Z2021JC001).
Background:To date,no direct comparisons have been performed to compare the effectiveness of all epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)against EGFR mutation-positive non-small cell lung...
关键词：Non-small cell lung cancer EGFR-TKI Network meta-analysis SURVIVAL TOXICITY 
Breast cancer risk associated with BRCA1 and BRCA2 pathogenic variants in the Eastern Chinese population
《Cancer Pathogenesis and Therapy》2025年第2期147-153,共7页Sanjian Yu Xia Qiu Zezhou Wang Jialong Xiao Hui Jie Hailin Shan Qing Shao Heng Xia Feng Cao Jun Li Cuixia Fu Liqin Chen Xiaofang Lu Tingting Su Qianqian Shengqun Hou Honglian Wang Ying Zheng Zhimin Shao Yun Liu Zhen Hu 
supported by the Shanghai Committee of Science and Technology Funds(No.14441901402);the National Natural Science Foundation of China(No.181972468);the AITA Biomedical Research Institute Breast Cancer Genetic Susceptibility Gene Research Fund.
Background:Population-based penetrance studies of breast cancer gene 1/2(BRCA1/2)pathogenic or likely pathogenic(P/LP)variants in the Eastern Chinese population are currently lacking;thus,we aimed to investigate the p...
关键词：BRCA1/2 gene mutations Breast cancer Chinese population Population-based studies 
Nomogram for predicting the risk and prognosis of lung metastasis of four subtypes of breast cancer:A population-based study from SEER
《Cancer Pathogenesis and Therapy》2025年第2期154-162,共9页Yuanfang Xin Guoxin Zhang Qiuxia Dong Yaobang Liu Xingfa Huo Yumei Guan Yonghui Zheng Qianqian Fang Dengfeng Ren Fuxing Zhao Zitao Li Xinlan Liu Jiuda Zhao 
supported by the Central Government Guiding Local Scientific and Technological Development Funds and Health Commission for Qinghai Province in China(No.2018-wjzdx-48).
Background:Breast cancer(BC)is the most diagnosed cancer worldwide,and patients'survival decreases with metastasis.We conducted a retrospective study using data derived from the Surveillance,Epidemiology,and End Resul...
关键词：Breast cancer Lung metastasis NOMOGRAM PROGNOSIS Surveillance Survival prediction model 
Factors affecting the place of death in patients with liver cancer in China,2013-2020:A population-based study
《Cancer Pathogenesis and Therapy》2025年第2期163-172,共10页Xiaosheng Ding Weiwei Shi Jinlei Qi Juan An Weiran Xu Hui Shi Xixi Zheng Xiaoyan Li 
supported by grants from the National Natural Science Foundation of China(Nos.81974361 and 82272768);the Beijing Municipal Education Commission-Beijing Natural Science Foundation Union Program(No.KZ202010025046).
Background:Despite the country's substantial liver cancer burden,there is limited research on the factors influencing the place of death(POD)of patients with liver cancer in China.This study aimed to delineate POD dis...
关键词：Liver neoplasms Place of death Socioeconomic status China 
Integrating multi-omics methods for personalized treatment of refractory chronic myelomonocytic leukemia with NRAS and TET2 mutations
《Cancer Pathogenesis and Therapy》2025年第2期173-175,共3页Chuandong Hou Bo Yang Yue Wang Lili Cai Ran Qin Bo Guo Jie Geng XueChun Lu 
supported by the Multi-Center Clinical Research Project of the National Clinical Research Center for Geriatric Diseases(No.NCRCG-PLAGH-20230010);the Key Military Health Project(No.23BJZ25).
Chronic myelomonocytic leukemia(CMML),a rare and malignant hematologic disorder,is classified as a myelodysplastic/myeloproliferative neoplasm(MDS/MPN).1 It poses a significant risk of progression to acute myeloid leu...
关键词：chronic myelomonocytic leukemia cmml personalized treatment demethylation therapy acute myeloid leukemia refractory chronic myelomonocytic leukemia multi omics Nras mutations Tet mutations 
Gastrointestinal stromal tumors with an uncommon primary mutation responded well to imatinib
《Cancer Pathogenesis and Therapy》2025年第2期176-178,共3页Gilani Shahid Mujeeb Qudsia Ikram Naima Khir Ibrahim 
Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract,driven by mutations in the proto-oncogene c-KIT or platelet-derived growth factor alpha(PDGFRA)gene in 85%-90%...
关键词：exon mutation mesenchymal tumors tyrosine kinase inhibitor tki gastrointestinal stromal tumors IMATINIB partial response gastrointestinal stromal tumors gists 
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