supported in part by the National Centre for Research and Development,Poland(No.WPC/BCL/2019);the Intergovernmental International Cooperation on Scientific and Technological Innovation Project of Chinese Ministry of Science and Technology(No.2017YFE0131600).
The zinc finger transcription factor B-cell CLL/lymphoma 11B gene(BCL11B,CTIP2)plays a crucial role in T-cell development,but its role in T-cell malignancies has not yet been definitively clarified.In the literature,2...
Beyond its core role in iron metabolism,erythroferrone(ERFE)has emerged as a key player with far-reaching implications in various hematologic disorders.Its regulatory effect on hepcidin underlines its significance in ...
Leukemias are a group of heterogeneous hematological malignancies driven by diverse genetic variations,and the advent of genomic sequencing technologies facilitates the investigation of genetic abnormalities in leukem...
supported by the National Key Research and Development Program of China(2021YFC2500300,2022YFC2502606);the Grants from the Beijing Municipal Science and Technology Commission(Z221100007422008);Major Program of the National Natural Science Foundation of China(82293630,82293633);CAMS Innovation Fund for Medical Sciences(2022-I2M-C&T-B-121,2023-I2MC&T-B-123);Peking University People’s Hospital Research and Development Funds(RD2023-08);Tongzhou District Distinguished Young Scholars(JCQN2023009);the Fundamental Research Funds for the Central Universities。
We aimed to identify dynamic changes of lysine(K)-specific methyltransferase 2A partial tandem duplications(KMT2A-PTD)before and after haploidentical donor hematopoietic stem cell transplantation(HID HSCT)and explore ...
It is now well-established that there are 2 distinct pathways for megakaryopoiesis.One is defined by the traditional stepwise differentiation pathway that progresses from hematopoietic stem and progenitor cells(HSPCs)...
The circulatory system is a complex network that serves as a lifeline for nutrient distribution,waste removal,and immune defense.At its core,th e blood ecosystem is a dynamic and finely tuned environment where diverse...
supported by the grants to H.Z.from the National Key R&D Program of China(2022YFA0103200);the National Natural Science Foundation of China(82325003,82230007);supported by the grants to R.G.from the Fundamental Research Funds for the Central Universities(2042023kf0057);the National Natural Science Foundation(NSFC)(82301997);supported by the grants to R.Y.from the National Natural Science Foundation of China(82200188);the Special Fund of China Postdoctoral Science Foundation(2022TQ0238);supported by the grants to H.Z.from the Fundamental Research Funds for the Central Universities(2042022dx0003 and 2042024kf1022).
Hematopoietic stem cells(HSCs)maintain homeostasis in the hematopoietic ecosystem,which is tightly regulated at multiple layers.Acute myeloid leukemia(AML)is a severe hematologic malignancy driven by genetic and epige...
supported by grants from the National Key Research and Development Program of China(2022YFA1103500,2020YFE0203000);the National Natural Science Foundation of China(81890990,82222003,92268117,82161138028);the Zhejiang Provincial Natural Science Foundation of China(Z24H080001);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019).
Accumulated evidence emerges that dynamic changes in human gut microbiota and microbial metabolites can alter the ecological balance of symbiotic hosts.The gut microbiota plays a role in various diseases through diffe...
supported in part by the National Key Research and Development Program of China(2022YFA1104100);the National Natural Science Foundation of China(82325002).
Megakaryocytes(MKs)constitute a small portion of bone marrow cells and are primarily responsible for producing platelets,which are essential for hemostasis and wound healing.Recent studies have revealed that MKs and p...
supported by the National Key R&D Program of China(2022YFA110350 and 2020YFA0112400);State Key Laboratory of Experimental Hematology Research Grant(ZK23-04);the National Natural Science Foundation of China(82000111).
Hematopoietic stem progenitor cells(HSPCs)are derived from a specialized subset of endothelial cells named hemogenic endothelial cells(HECs)via a process of endothelial-to-hematopoietic transition during embryogenesis...