《Blood Science》

作品数:190被引量:92H指数:4
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《Blood Science》
主办单位:中华医学会
最新期次:2024年4期更多>>
发文主题:BLOODHEMATOPOIETIC_STEM_CELLPATIENTSHEMATOPOIETICTHERAPY更多>>
发文领域:医药卫生文化科学生物学建筑科学更多>>
发文基金:国家自然科学基金国家重点基础研究发展计划天津市自然科学基金中国博士后科学基金更多>>
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Dual role of BCL11B in T-cell malignancies
《Blood Science》2024年第4期36-39,共4页Grzegorz K.Przybylski Julia Przybylska Yangqiu Li 
supported in part by the National Centre for Research and Development,Poland(No.WPC/BCL/2019);the Intergovernmental International Cooperation on Scientific and Technological Innovation Project of Chinese Ministry of Science and Technology(No.2017YFE0131600).
The zinc finger transcription factor B-cell CLL/lymphoma 11B gene(BCL11B,CTIP2)plays a crucial role in T-cell development,but its role in T-cell malignancies has not yet been definitively clarified.In the literature,2...
关键词:BCL11B BER CTIP2 Rit1 T-cell malignancy T-ALL TCL 
Erythroferrone in focus:emerging perspectives in iron metabolism and hematopathologies
《Blood Science》2024年第4期40-46,共7页Sadia Babar Muhammad Saboo 
Beyond its core role in iron metabolism,erythroferrone(ERFE)has emerged as a key player with far-reaching implications in various hematologic disorders.Its regulatory effect on hepcidin underlines its significance in ...
关键词:Erythroferrone HEPCIDIN IRON Iron metabolism 
Mitochondrial genetic variations in leukemia:a comprehensive overview被引量:1
《Blood Science》2024年第4期47-51,共5页Ao Zhang Wenbing Liu Shaowei Qiu 
Leukemias are a group of heterogeneous hematological malignancies driven by diverse genetic variations,and the advent of genomic sequencing technologies facilitates the investigation of genetic abnormalities in leukem...
关键词:LEUKEMIA mtDNA copy number variations mtDNA mutations mtDNA sequencing Natural genetic barcodes Prognostic marker 
Pre-transplantation levels of lysine(K)-specific methyltransferase 2A(KMT2A)partial tandem duplications can predict relapse of acute myeloid leukemia patients following haploidentical donor hematopoietic stem cell transplantation
《Blood Science》2024年第4期52-59,共8页Dao-Xing Deng Xiao-Hang Ma Ze-Hua Wu Xiao-Hui Zhang Lan-Ping Xu Yu Wang Chen-Hua Yan Huan Chen Yu-Hong Chen Wei Han Feng-Rong Wang Jing-Zhi Wang Xiao-Jun Huang Xiao-Su Zhao Xiao-Dong Mo 
supported by the National Key Research and Development Program of China(2021YFC2500300,2022YFC2502606);the Grants from the Beijing Municipal Science and Technology Commission(Z221100007422008);Major Program of the National Natural Science Foundation of China(82293630,82293633);CAMS Innovation Fund for Medical Sciences(2022-I2M-C&T-B-121,2023-I2MC&T-B-123);Peking University People’s Hospital Research and Development Funds(RD2023-08);Tongzhou District Distinguished Young Scholars(JCQN2023009);the Fundamental Research Funds for the Central Universities。
We aimed to identify dynamic changes of lysine(K)-specific methyltransferase 2A partial tandem duplications(KMT2A-PTD)before and after haploidentical donor hematopoietic stem cell transplantation(HID HSCT)and explore ...
关键词:Acute myeloid leukemia Allogeneic hematopoietic stem cell transplantation HAPLOIDENTICAL KMT2A-PTD RELAPSE 
Adult megakaryopoiesis:when taking a short-cut results in a different final destination
《Blood Science》2024年第4期60-61,共2页Wenxu Zhu Gavin Tjin Louise E.Purton 
It is now well-established that there are 2 distinct pathways for megakaryopoiesis.One is defined by the traditional stepwise differentiation pathway that progresses from hematopoietic stem and progenitor cells(HSPCs)...
关键词:STEPWISE ERYTHROID sis 
Deciphering the hematopoietic cell ecosystem
《Blood Science》2024年第4期1-2,共2页Hui Cheng 
The circulatory system is a complex network that serves as a lifeline for nutrient distribution,waste removal,and immune defense.At its core,th e blood ecosystem is a dynamic and finely tuned environment where diverse...
关键词:MAINTAIN ECOSYSTEM NETWORK 
Epigenetic modifications in hematopoietic ecosystem:a key tuner from homeostasis to acute myeloid leukemia
《Blood Science》2024年第4期3-12,共10页Shuxin Yao Rongxia Guo Wen Tian Yanbing Zheng Jin Hu Guoqiang Han Rong Yin Fuling Zhou Haojian Zhang 
supported by the grants to H.Z.from the National Key R&D Program of China(2022YFA0103200);the National Natural Science Foundation of China(82325003,82230007);supported by the grants to R.G.from the Fundamental Research Funds for the Central Universities(2042023kf0057);the National Natural Science Foundation(NSFC)(82301997);supported by the grants to R.Y.from the National Natural Science Foundation of China(82200188);the Special Fund of China Postdoctoral Science Foundation(2022TQ0238);supported by the grants to H.Z.from the Fundamental Research Funds for the Central Universities(2042022dx0003 and 2042024kf1022).
Hematopoietic stem cells(HSCs)maintain homeostasis in the hematopoietic ecosystem,which is tightly regulated at multiple layers.Acute myeloid leukemia(AML)is a severe hematologic malignancy driven by genetic and epige...
关键词:Acute myeloid leukemia DNA methylation HEMATOPOIESIS Hematopoietic stem cells Leukemia stem cells RNA modification 
Gut microbiota plays pivotal roles in benign and malignant hematopoiesis
《Blood Science》2024年第4期13-21,共9页Yuxuan Li Biao Zhang Lingli Jiang Tao Cheng Hui Cheng Pengxu Qian 
supported by grants from the National Key Research and Development Program of China(2022YFA1103500,2020YFE0203000);the National Natural Science Foundation of China(81890990,82222003,92268117,82161138028);the Zhejiang Provincial Natural Science Foundation of China(Z24H080001);the Haihe Laboratory of Cell Ecosystem Innovation Fund(22HHXBSS00016);the CAMS Initiative for Innovative Medicine(2021-I2M-1-019).
Accumulated evidence emerges that dynamic changes in human gut microbiota and microbial metabolites can alter the ecological balance of symbiotic hosts.The gut microbiota plays a role in various diseases through diffe...
关键词:Fecal microbiota transplantation Graft-versus-host disease Gut microbiota Hematologic diseases Hematopoietic stem cells 
Versatility of megakaryocytes in homeostasis and disease
《Blood Science》2024年第4期22-26,共5页Daosong Wang Jiayi Xie Meng Zhao 
supported in part by the National Key Research and Development Program of China(2022YFA1104100);the National Natural Science Foundation of China(82325002).
Megakaryocytes(MKs)constitute a small portion of bone marrow cells and are primarily responsible for producing platelets,which are essential for hemostasis and wound healing.Recent studies have revealed that MKs and p...
关键词:Aging Hematopoietic stem cell Immune responses MEGAKARYOCYTE NICHE PLATELET 
New insights into the endothelial origin of hematopoietic system inspired by“TIF”approaches
《Blood Science》2024年第4期27-35,共9页Siyuan Hou Xia Guo Junjie Du Xiaochen Ding Xiaowei Ning Haizhen Wang Haifeng Chen Bing Liu Yu Lan 
supported by the National Key R&D Program of China(2022YFA110350 and 2020YFA0112400);State Key Laboratory of Experimental Hematology Research Grant(ZK23-04);the National Natural Science Foundation of China(82000111).
Hematopoietic stem progenitor cells(HSPCs)are derived from a specialized subset of endothelial cells named hemogenic endothelial cells(HECs)via a process of endothelial-to-hematopoietic transition during embryogenesis...
关键词:Endothelial-to-hematopoietic transition Genetic lineage tracing Hematopoietic stem progenitor cells Hemogenic endothelial cell Single-cell technology 
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