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Osteoblast-derived extracellular vesicles exert bone formation effects by WIF1-mediated regulation of mitophagy: 《Medicine Plus》2024年第2期48-63,共16页Yuyuan Gu Jing Zhao Jian Wang Yingying Jiang Yingying Jing Ke Xu Jiacan Su; supported by the Major Research Plan of the National Natural Science Foundation of China(92249303);the Key Project of the National Natural Science Foundation of China(82230071).; Background:Osteoporosis arises mainly from an imbalance in bone remodeling,characterized by the impaired ability of osteoblasts(OBs)to form new bone.A sig-nificant challenge remains in identifying and validating key g...; 关键词：WIF1 OSTEOPOROSIS OSTEOBLAST MITOPHAGY Extracellular vesicle Bone formation

Targeting RIP3 inhibits osteoarthritis development by restoring anabolic-catabolic balance in the bone-cartilage unit: 《Medicine Plus》2024年第2期26-47,共22页Jin Cheng Cheng Wang Jingxian Zhu La Li Qingyang Meng Yifei Fan Wenqiang Yan Zhipeng Zhu Yanyan Shi Yuanyi Wang Bin Shen Fengbiao Mao Yingfang Ao Xiaoqing Hu; supported by the National Natural Science Foundation of China(32000923,82072486,and 81972101);Beijing Municipal Natural Science Foundation(7214304);Peking University Third Hospital Clinical Key Project Talent Program(BYSYZD2021039).; Background:Osteoarthritis(OA)is a debilitating joint disorder characterized by pro-gressive cartilage degeneration.During OA,subchondral bone undergoes micro-structural and molecular changes that precede cartilage deg...; 关键词：OSTEOARTHRITIS CARTILAGE Subchondral bone Metabolism homeostasis Receptor-interacting protein kinase 3 NECROPTOSIS

Information for Authors: 《Medicine Plus》2024年第2期F0002-F0002,共1页; Aims&Scope Medicine Plus is an open-access,peer-reviewed,international general medical journal.We publish the most innovative,forward-looking,and influential research results,authoritative reviews,expert consensuses,a...; 关键词：INFORMATION AUTHORS

Difficult speech-on-speech recognition as a behavioral indicator in children with attention deficit hyperactivity disorder: 《Medicine Plus》2024年第2期20-25,共6页Jianing Fan Yang Liu Siyi Wang Qian Zhu Zhaohui Niu Ying Li Qian Wang Yayue Gao; supported by the National Natural Science Foundation of China(32200862);the Institute of Psychology,CAS(GJ202005);Beihang University(4304165).; Attention deficit hyperactivity disorder(ADHD)is one of the most prevalent neurodevelopmental disorders,which is characterized with significant difficulties in attention regulation,hyperactivity,and impulsivity.These ...; 关键词：attention speech CHILDREN with BEHAVIORAL DEFICIT DIFFICULT disorder HYPERACTIVITY INDICATOR

Progresses in genetic testing in congenital heart disease: 《Medicine Plus》2024年第2期64-77,共14页Han Gao Ying Liu Wei Sheng Weinian Shou Guoying Huang; supported by the National Key Research and Development Program of China(2021YFC2701000 and 2021YFC2701004);the National Natural Science Foundation of China(82270312);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-002).; Congenital heart disease(CHD)encompasses a range of structural malformations affecting the heart and major blood vessels present at birth.The genetic under-pinnings of CHD have long been recognized as pivotal,facilita...; 关键词：Congenital heart disease Genetic testing GENETICS Clinical practice

Tumor deposits in colorectal and gastric cancers: 《Medicine Plus》2024年第2期78-88,共11页Ruirong Yao Xianchun Gao Jun Yu Shibo Wang Xishan Wang Kay Uehara Yongzhan Nie; supported by the National Natural Science Foundation of China(82202837 and 81972761);the National Key R&D Program of China(2016YFC1303200); Tumor deposits(TDs),initially recognized in colorectal cancer(CRC),have been identified in various other cancer types,including gastric cancer(GC),rendering them a widely studied adverse prognostic factor in gastroint...; 关键词：Tumor deposits Colorectal cancer Gastric cancer TNM staging PROGNOSIS

Paradigm shift in psychiatric neuroscience:Multidimensional integrative theory被引量：2: 《Medicine Plus》2024年第2期1-5,共5页Zhu-Qing Gong Bharat B.Biswal Xi-Nian Zuo; supported by the STI 2030-the major projects of the Brain Science and Brain-Inspired Intelligence Technology(2021ZD0200500);the China Postdoctoral Science Foundation(2023M730302).; Abnormal structure and function of the human brain cause various mental and neurological disorders.The search for neurobiological mechanisms and biomarkers associated with psychiatric disorders has always been a focal...; 关键词：dimension shift siona multi INTEGRATIVE NEUROSCIENCE PARADIGM PSYCHIATRIC THEORY

Health research in the era of artificial intelligence:Advances in gene-editing study被引量：1: 《Medicine Plus》2024年第2期89-101,共13页Mengyao Dai Xiangyang Li Qi Zhang Tingbo Liang Xingxu Huang Qihan Fu; supported by the National Key R&D Program of China(2021YFA0804702);the Natural Science Foundation of Zhejiang Province(Y23H160098).; In recent years,gene editing technology,represented by clustered regularly inter-spaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9)has made a revolutionary breakthrough.Base editing techniques ...; 关键词：Base editing Gene editing High-throughput screening Functional genomics Artificial intelligence

Large language models illuminate a progressive pathway to artificial intelligent healthcare assistant被引量：2: 《Medicine Plus》2024年第2期102-124,共23页Mingze Yuan Peng Bao Jiajia Yuan Yunhao Shen Zifan Chen Yi Xie Jie Zhao Quanzheng Li Yang Chen Li Zhang Lin Shen Bin Dong; supported by the National Natural Science Foundation of China(91959205,U22A20327,82203881,12090022,11831002,and 81801778);Beijing Natural Science Foundation(7222021);Beijing Hospitals Authority Youth Programme(QML20231115);Clinical Medicine Plus X-Young Scholars Project of Peking University(PKU2023LCXQ041);Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer(2020B121201004).; With the rapid development of artificial intelligence,large language models(LLMs)have shown promising capabilities in mimicking human-level language comprehen-sion and reasoning.This has sparked significant interest i...; 关键词：Large language models Artificial intelligence Medicine Healthcare assistant Prompt engineering In-context learning

A molecular glue for P53: 《Medicine Plus》2024年第2期18-19,共2页Hai-Kun Liu; Protein degradation is important for the dynamic regulation of protein levels in cells.Proteins are recognized by ubiquitin ligases,which tag the target proteins with ubiquitin,which will lead to degradation of the ta...; 关键词：MOLECULAR GLUE

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