《Medical Theory and Hypothesis》

作品数:36被引量:2H指数:1
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《Medical Theory and Hypothesis》
主办单位:TMR Publishing Group
最新期次:2023年2期更多>>
发文主题:TREATMENTTRADITIONAL_CHINESE_MEDICINEINTERVENTIONTHEORETICALCHINESE_MEDICINE更多>>
发文领域:医药卫生自动化与计算机技术经济管理语言文字更多>>
发文基金:国家自然科学基金更多>>
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Construction of gene/protein interaction networks and enrichment pathway analysis for paroxysmal nocturnal hemoglobinuria and aplastic anemia
《Medical Theory and Hypothesis》2023年第2期19-26,共8页Gong-Xi Liu Zheng-Di Sun Chao Zhou Jun-Yu Wei Jing Zhuang 
Background:To develop a protein-protein interaction network of Paroxysmal nocturnal hemoglobinuria(PNH)and Aplastic anemia(AA)based on genetic genes and to predict pathways underlying the molecular complexes in the ne...
关键词:protein interaction networks paroxysmal nocturnal hemoglobinuria Online Mendelian Inheritance in Man database aplastic anemia biological pathways 
A bioinformatics-based study of the mechanism of JQ-1 on BET protein and atherosclerosis induced by vascular smooth muscle cell proliferation
《Medical Theory and Hypothesis》2023年第2期27-34,共8页Shuo Zhang Peng-Yu Wang Qing Lan Guan-Di Ma You-Zhi Zhang 
supported by a grant from Key Project of Education Commission of Hubei Province(D20202802);Hubei Key Laboratory of Diabetes and Angiopathy Program(2020XZ10)of Hubei University of Science.
Background:Based on previous theoretical studies,JQ-1 as a common inhibitor of bromodomain and extraterminal(BET)proteins was used to treat a variety of diseases.Therefore,we aimed to explore the mechanism of action o...
关键词:JQ-1 BET protein vascular smooth muscle cell BIOINFORMATICS molecular docking 
The role and research progress of PI3K/AKT signaling pathway in non-traumatic osteonecrosis of the femoral head
《Medical Theory and Hypothesis》2023年第2期35-40,共6页Feng-Ming Wang Ya-Nan Wang Zhen-Yu Wang Song Fu 
Non-traumatic osteonecrosis of the femoral head(NONFH)is one of the most common orthopedic diseases,influenced by multiple signaling pathways and inflammatory factors.The PI3K/AKT signaling pathway is closely related ...
关键词:non-traumatic osteonecrosis of the femoral head PI3K/AKT signaling pathway lipid metabolism APOPTOSIS AUTOPHAGY intravascular coagulation 
The Role of Geographic Variation in Polycystic Ovary Syndrome:Developing a Theoretical Framework for a Differentiated Investigation Protocol
《Medical Theory and Hypothesis》2023年第2期1-5,共5页Lu-Yuan Yu Rui-Juan Liu 
This article explores the geographical factors of polycystic ovary syndrome(PCOS)based on the prevalence of PCOS in selected regions of the world and the associated data and thus proposes a proposal for the establishm...
关键词:PCOS GEOGRAPHIC disease diagnosis and treatment 
Identification and validation of Temozolomide resistance hub gene LncRNA MOCS2-DT in glioblastoma
《Medical Theory and Hypothesis》2023年第2期6-14,共9页Lang Li Qiang Gu Jia-Hao Yao Bei Zhou Fa-Yan Dong Xue-Feng Wang 
Background:Temozolomide(TMZ)is an important adjuvant chemotherapy drug after glioma surgery.However,with the progress of treatment,most patients will gradually develop drug resistance.Long non-coding RNA(lncRNA)in the...
关键词:WCGNA lncRNA glioblastoma resistance CHEMOTHERAPY BIOMARKER 
Exploring the mechanisms of lipid regulation in metabolic syndrome: Recent developments
《Medical Theory and Hypothesis》2023年第2期15-18,共4页Gui-Jie Wang Qian Shen Chuan-Long Zhang 
Metabolic syndrome(MetS)is an individual accumulation of multiple abnormal metabolic indicators,with insulin resistance and central obesity at its core.Adipose tissue is the core component of MetS,and adipokines secre...
关键词:metabolic syndrome adipose tissue ADIPOKINES 
Discussion on depression by thinking of t raditional Chinese medicine被引量:1
《Medical Theory and Hypothesis》2023年第1期1-4,共4页Yi-Tong Huang Cong-Cong Chang 
Depression is a common mental disease characterized by abnormal emotional changes,which belongs to the category of“melancholia syndrome”and Chinese emotion medicine.The main clinical manifestations are mood depressi...
关键词:DEPRESSION TCM theory “inner depression”and“outer depression” CONSTITUTION susceptible psychological therapy SYMPTOMATIC 
Exploring the pathogenesis of idiopathic granulomatous mastitis based on the prolactin theory
《Medical Theory and Hypothesis》2023年第1期5-9,共5页Yan Zhang Wen-Di Liu Yan-Jun Chen Han Liu Xiao-Fei Liu 
Prolactin(PRL),as a cytokine,plays a variety of multidirectional roles in immunity and inflammation.An autoimmune condition known as idiopathic granulomatous mastitis(IGM)involves many inflammatory cells and cytokines...
关键词:PROLACTIN idiopathic granulomatous mastitis IMMUNITY theoretical discussion mechanism of action 
Identification of the risk of breast cancer in patients suffering from endometriosis:A meta-analysis
《Medical Theory and Hypothesis》2023年第1期10-17,共8页Xue Wang Jin-Yu Xia Jin-Xue Xia Jiu-Wei Li 
Background:Breast cancer and endometriosis are two significant diseases that threaten the health of female worldwide.The relationship between them is still in a state of controversy.In present study,we identified the ...
关键词:breast cancer ENDOMETRIOSIS risk analysis 
Discussion on reprogramming of tumor energy metabolism and intervention of traditional Chinese medicine based on the theory of“collateral Q i stagnation”
《Medical Theory and Hypothesis》2023年第1期18-21,共4页Yi Li Gui-Jie Wang Chuan-Long Zhang Bo Pang 
supported by Beijing Natural Science Foundation(No.7222296);Major research project of oncology of scientific and technological innovation project of China Academy of Chinese Medical Sciences(No.CI2021A01805).
The theory of stagnation of collateral Qi(Chinese medicine refers to the most fundamental and subtle substances thatconstitute the human body and maintain life activities,and also has the meaning of physiological func...
关键词:stagnation of collaterals TUMOUR energy metabolism reprogramming tumor microenvironment integrated traditional Chinese and Western Medicine 
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