C-TERMINAL

作品数：64被引量：139H指数：7
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相关领域：生物学医药卫生更多>>
相关作者：魏开华王红霞王鸿丽刘炳玉李萍更多>>
相关机构：军事医学科学院哈尔滨医科大学青岛大学山西大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划重庆市自然科学基金北京市自然科学基金更多>>
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C-terminal frameshift mutations generate viable knockout mutants with developmental defects for three essential protein kinases
《aBIOTECH》2024年第2期219-224,共6页Yun Zhang Miao-Miao Cui Run-Nan Ke Yue-Dan Chen Kabin Xie 
supported by the National Natural Science Foundation of China(32293243);Fundamental Research Funds for the Central Universities(2021ZKPY002,2662023PY006);supported by Hainan Yazhou Bay Seed Laboratory and the China National Seed Group(project B23YQ1516).
Loss-of-function mutants are fundamental resources for gene function studies.However,it is difficult to generate viable and heritable knockout mutants for essential genes.Here,we show that targeted editing of the C-te...
关键词：CRISPR/Cas9 Lethal mutant Protein kinases Genome editing C-TERMINUS 
Exploration of C-terminal CX3CL1 for reducing age-dependent neurodegeneration
《Neural Regeneration Research》2023年第12期2667-2668,共2页Jacob Hudobenko Manoshi Gayen Marc RBenoit Neeraj Singh Riqiang Yan 
grants RF1AG058261, AG025493, NS074256, and AG046929 from the National Institutes of Health (to RY);the Cure Alzheimer’s Fund。
Owing to the increasing life expectancy, the prevalence of age-dependent neurodegenerative diseases will exert an enormous toll on our aging population, their caregivers and the healthcare system. It is anticipated th...
关键词：diseases ALZHEIMER PREVALENCE 
Dock-able linear and homodetic di, tri, tetra and pentapeptide library from canonical amino acids: SARS-CoV-2 Mpro as a case study
《Journal of Pharmaceutical Analysis》2023年第5期523-534,共12页Sarfraz Ahmad Muhammad Usman Mirza John F.Trant 
Peptide-based therapeutics are increasingly pushing to the forefront of biomedicine with their promise of high specificity and low toxicity.Although noncanonical residues can always be used,employing only the natural ...
关键词：DIPEPTIDES TRIPEPTIDES Tetrapeptides Pentapeptides N-to-C-terminal cyclic peptides Peptide library 
C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice
《Genes & Diseases》2023年第3期643-646,共4页Chun-Lung Chiu Shiao-Ya Hong Ying Tan Yuh-Ru Julie Lee Yi-Ping Shih Clifford GTepper Su Hao Lo 
supported in part by The National Institutes of Health,USA(No.DK64111,CA102537,and HL139473).The Genomics Shared Resource is supported by the UC Davis Comprehensive Cancer Center Support Grant awarded by the National Cancer Institute,USA(No.NCI P30CA093373).
Tensin-1(TNS1)is a 220 kD focal adhesion protein that binds to actin filaments,integrin receptors,small GTPases,tyrosine-phosphorylated proteins,and lipids.1 These binding activities enable TNS1 to link the actin cyto...
关键词：KIDNEY TENSIN thereby 
Association of bone turnover biomarkers with severe intracranial and extracranial artery stenosis in type 2 diabetes mellitus patients被引量：1
《World Journal of Diabetes》2023年第5期594-605,共12页Si-Cong Si Wei Yang Hong-Yu Luo Yi-Xin Ma Huan Zhao Jia Liu 
Supported by Beijing Municipal Hospital Management Center“Cultivation Plan”,No.PX2022032.
BACKGROUND Intracranial and extracranial artery stenosis is associated with cerebral infarction.Vascular calcification and atherosclerosis are the main causes of stenosis and major risk factors for cardiovascular and ...
关键词：Bone turnover biomarkers Type 2 diabetes mellitus OSTEOCALCIN C-terminal cross-linked telopeptide of type I collagen Procollagen type I N-peptide Intracranial and extracranial artery stenosis 
C-terminal variants of the P2X7 receptor are associated with prostate cancer progression and bonemetastasis–evidence from clinical and pre-clinical data被引量：1
《Cancer Communications》2023年第3期400-404,共5页Haiping Song Hector Manuel Arredondo Carrera Alexandria Sprules Ying Ji Tongsong Zhang Jiepei He Eleanor Lawrence Alison Gartland Jian Luo Ning Wang 
Dear Editor Bone is the most common site for metastasis in prostate cancer(PCa),and identifying clinically useful biomarkers to predict the risk of currently incurable bone metastases is a major priority in PCa resear...
关键词：metastasis cancer CLINICAL 
Single molecular insight into steric effect on C-terminal amino acids with various hydrogen bonding sites被引量：1
《Chinese Chemical Letters》2022年第10期4649-4654,共6页Yunzhi Xie Chunhua Liu Linxiu Cheng Yulan Fan Huifang Li Wei Liu Lei Zhu Xun Li Ke Deng Qingdao Zeng Shoufa Han 
supported by the Ministry of Science and Technology(No.2017YFA0205000);National Natural Science Foundation of China(Nos.21303024,21365003,21463003,51478123,21962003,21902033);the National Key Basic Research Program of China(No.2012CB933001);the Chinese Academy of Sciences(No.YZ201318);The jiangxi Provincial"Ganpo Talents 555 Projects",Jiangxi Provincial Education Department Fund(No.KJLD13080);Jiangxi Provincial Funds for Distinguished Young Scientists(No.20153BCB23001);Jjiangxi Provincial Project of Scientific and Technological Innovation Team(No.20152BCB24008);Jiangxi Province Youth Science Foundation Project(No.20192BAB216013);Science and Technology Project of Jiangxi Province Education Department(No.180775)are also gratefully acknowledged.
Amino acids are basic units to construct a protein with the assistance of various interactions.During this building process,steric hindrance derived from amino acid side groups or side chains is a factor that could no...
关键词：C-terminal amino acids Steric effect Bonding site Scanning tunneling microscopy DFT calculations 
FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling被引量：4
《Acta Pharmacologica Sinica》2021年第12期2106-2119,共14页Zuo-lin Li Bin Wang Lin-li Lv Tao-tao Tang Yi Wen Jing-yuan Cao Xiao-xiao Zhu Song-tao Feng Steven DCrowley Bi-cheng Liu 
supported by the National Natural Science Foundation of China(82000648,8203000544,81720108007,and 81470922);the National Key Research and Development Program of China(2018YFC1314002);the Natural Science Foundation of Jiangsu Province(BK20200363);the Innovative and Entrepreneurial Talent(Doctor)of Jiangsu Province;the Special Fund for Basic Scientific Research of Central Universities(2242020K40151).
Incomplete recovery from episodes of acute kidney injury(AKI)can predispose patients to develop chronic kidney disease(CKD).Although hypoxia-inducible factor-1α(HIF-1α)is a master regulator of the response to hypoxi...
关键词：acute kidney injury chronic kidney disease renal fibrosis HIF-1αC-terminal activation domain KLF5 FIH-1 PX-478 
Newly identified genetic variant rs2294693 in UNC5CL gene is associated with decreased risk of esophageal carcinoma in the J&K Population–India
《BIOCELL》2021年第3期665-670,共6页RUCHI SHAH SONALI VERMA AMRITA BHAT GH RASOOL BHAT VARUN SHARMA INDU SHARMA HEMENDER SINGH SANDEEP KAUL EKTA RAI SWARKAR SHARMA 
Esophageal cancer is the second most common type of cancer after lung carcinoma in the state of Jammu and Kashmir(J&K).The understanding of genetics in Esophageal cancer development is poor in the state.Genome wide as...
关键词：Esophageal cancer Single nucleotide polymorphism Unc-5 Family C-Terminal(UNC5CL) Candidate gene 
CtBP家族在肿瘤中的相关研究进展
《中国科技期刊数据库 医药》2021年第2期198-199,共2页胡艺凡 文彬 蹇顺海 
肿瘤的发生、发展是个多因素,多步骤,多阶段的复杂过程,其中涉及到了多个因素的相互作用,羧基末端结合蛋白(c—terminal—bindingprotein,CtBP)在进化上保守,主要发挥转录辅抑制因子的功能。研究发现CtBP与多个肿瘤相关基因的转录调控有...
关键词：羧基末端结合蛋白(C-terminal-binding PROTEIN CtBP) 上皮-间质转换(epithelial-mesenchymal TRANSITION 
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