supported by grants from Shenzhen Science and Technology Project(No.JCYJ20220531091817039)。
Background Myocardial ischemia-reperfusion injury is an important clinical problem.Hypoxia-reperfusion(HR)triggers a series of complex cellular reactions and pathological changes.In recent years,the role of N-6-methyl...
supported by Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515110055)。
Objective: Qili Qiangxin(QLQX), a compound herbal medicine formula, is used effectively to treat congestive heart failure in China. However, the molecular mechanisms of the cardioprotective effect are still unclear. T...
Supported by the Foundation of Fujian University of Traditional Chinese Medicine(No.X2013026);the Developmental Fund of Chen Ke-ji Integrative Medicine(No.CKJ2013016);the Education Department of Fujian Province(No.JA14163)
Objectives: To investigate the protective effects of Shexiang Tongxin Dropping Pill(麝香通心滴丸,STP) on Na2S2O4-induced hypoxia-reoxygenation injury in cardiomyoblast H9c2 cells. Methods: The cell viability and level...
supported by the Natural Science Foundation of Beijing City(7092093)
Leukocyte transendothelial migration and sequestration are two distinct outcomes following leukocyte adhesion to endotheli- um during ischemia-reperfusion injury, in which platelets may play a pivotal role. In the pre...
A computational analysis of genome-scale transcriptomic data collected on -1,700 tissue samples of three cancer types: breast carcinoma, colon adenocarcinoma and lung adenocarcinoma, revealed that each tissue consist...
Supported by The "Eleventh Five-year Plan" for Medical Sci-ence Development of PLA,No.06MB243;the National Natural Science Foundation of China,No.81101101 and No.51273165;the Key Project of Chinese Ministry of Education,No.212149;the Projects of Sichuan Province,No.2010SZ0294,No.2011JQ0032 and No.12ZB038
AIM: To investigate the mechanisms of chloride intracellular channel 1 (CLIC1) in the metastasis of colon cancer under hypoxia-reoxygenation (H-R) conditions.
Objectives: Chunghyuldan (CHD), a combinatorial drug that has anti-hyperlipidemic and anti inflammatory activities, has been shown to reduce infarct volume in a focal ischemia-reperfusion rat model. To explore the ...
BACKGROUND: Cerebral hippocampal astrocytes are more sensitive.to ischemic injury than neurons. Hypoxic-ischemic brain injury induces profound astrocyte apoptosis, and propofol may protect against astrocyte apoptosis...
This work was supported by National Natural Science Foundation of China (No 30800464).
Objective Previous investigations have shown that N-acetylcysteine (NAC) could regulate diverse cell type's apoptosis. The purpose of this study was to evaluate the mechanism of NAC reversed apoptosis of cardiomyoc...
Background Although the insulinotropic role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes mellitus has been substantiated, its role in cardioprotection remains largely unknown. This study aimed to determine ...