QUINAZOLINE

作品数：38被引量：23H指数：2
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相关领域：医药卫生理学更多>>
相关作者：赵保丽黄诚丁盼盼张晶晶邹美芬更多>>
相关机构：中山大学首都师范大学四川大学北京大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Oncology Research》《癌症》《Chinese Journal of Structural Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划浙江省杰出青年科学基金Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry更多>>
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A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
《Oncology Research》2024年第5期849-875,共27页NILAM BHUSARE MAUSHMI KUMAR 
The authors are thankful to Dr.Mayur Yergeri and Science and Engineering Research Board(SERB),Government of India,New Delhi,(CRG/2019/001452).
Glioblastoma,the most aggressive form of brain tumor,poses significant challenges in terms of treatment success and patient survival.Current treatment modalities for glioblastoma include radiation therapy,surgical int...
关键词：GLIOBLASTOMA Kinase pathway PYRIMIDINE QUINAZOLINE HETEROCYCLES 
Trifluoromethyl enable high-performance single-emitter white organic light-emitting devices based on quinazoline acceptor
《Chinese Chemical Letters》2024年第4期442-446,共5页Xiangan Song Shaogang Shen Mengyao Lu Ying Wang Yong Zhang 
the supports by the National Natural Science Foundation of China (No.22175049);the Opening Project of Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education,Jianghan University (No.JDGD-202213);the support of the Fundamental Research Funds for the Central Universities (Harbin Institute of Technology)。
Single-emitter white organic light-emitting diode(WOLED) based on small organic molecule exhibits great potential in simplifying fabrication process of WOLEDs. However, the design and synthesis of molecule for highly ...
关键词：Single-emitter white organic light-emitting diode Conformational isomerism Thermally activated delayed fluorescence TRIFLUOROMETHYL Exciton utilization 
Study on the in vitro anti ovarian cancer effect and mechanism of quinazoline derivative(N111)
《Journal of Hainan Medical University》2023年第19期9-17,共9页LI Yan HUANG Qiang HUANG Yin-jiu LIU Gang LIU Jian 
Anhui Province University Natural Science Research Project (No.KJ2019A0363)。
Objective:To study the anti-ovarian cancer effect and mechanism of Quinazoline derivative(N111)in vitro;Method:Using an online database to predict the therapeutic targets of N111 for ovarian cancer,and conducting biol...
关键词：Quinazoline derivatives ANTI-TUMOR Apoptosis Mitochondrial membrane potential ROS 
Design,Synthesis and Anticancer Activity Evaluation of Novel Quinazoline Derivatives as EFGR Inhibitors被引量：1
《Chinese Journal of Structural Chemistry》2021年第7期933-941,841,共10页LI Hong-Xia QIAN Yu-Mei XU Li-Sheng 
the Suzhou University Natural Science Key Project(No.2017yzd11,2020ykf23,2020ykf24);National Engineering Laboratory Open Fund Project(NEL-SCRT 002);Natural Science Foundation of An Hui Province(No.1908085MC100,KJ2020A0729,KJ2020A0737)。
Malignant tumor is one of the major diseases that seriously threaten human health today.Compared with traditional chemotherapy,targeted drug therapy has become a new idea of tumor therapy.And EGFR(epidermal growth fac...
关键词：hydroxyquinazoline EFGR antitumor activity TOXICITY APOPTOSIS 
In vitro anti-plasmodial activity of new synthetic derivatives of 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine
《Asian Pacific Journal of Tropical Medicine》2021年第3期128-138,共11页Azar Tahghighi Akram Abouie Mehrizi Sedigheh Zakeri 
supported by the grant(No.852)from Pasteur Institute of Iran to A.A.Mehrizi
Objective:To evaluate new compounds synthesized by integrating quinoline,quinazoline,and acridine rings with the active moiety of(5-nitroheteroaryl)methylene hydrazine.Methods:A new series of compounds(1a,1b,2a,2b,3a,...
关键词：PLASMODIUM 5-nitroheteroaryl HYDRAZINE QUINOLINE QUINAZOLINE ACRIDINE 
Two New Quinazoline Derivatives from the Moss Endophytic Fungus Aspergillus sp. and Their Anti-inflammatory Activity
《Natural Products and Bioprospecting》2021年第1期105-110,共6页Ning-Ning Wang Chun-Yu Liu Tian Wang Yue-Lan Li Ke Xu Hong-Xiang Lou 
the National Natural Science Foundation of China(Nos.81874293 and 81630093);for financial support and Major Basic Research Program of Shandong Province(ZR2019ZD26).
Two new quinazoline derivatives versicomides E(1)and F(2),and 10 known compounds(3-12)were isolated from the moss endophytic fungus Aspergillus sp.Their structures were determined on the basis of extensive spectroscop...
关键词：Endophytic fungus QUINAZOLINE Anti-inflammatory activity 
Stable deep blue organic light emitting diodes with CIE of y<0.10 based on quinazoline and carbazole units被引量：1
《Chinese Chemical Letters》2020年第5期1188-1192,共5页Bowen Li Xiang'an Song Xi Jiang Zhiyi Li Fengyun Guo Ying Wang Liancheng Zhao Yong Zhang 
supports from the National Key Research and Development Plan(No.2016YFB0401004);supports from the Open Fund of Beijing National Laboratory for Molecular Sciences(BNLMS,No.BNLMS20160131);the Fundamental Research Funds for the Central Universities(Harbin Institute of Technology)。
Achieving stable deep blue organic light emitting diodes(OLEDs)with narrow full width at half maximum(FWHM)and color gamut in the range of the commission International de L’Eclairage(CIE)ofy≤0.10 is still challengin...
关键词：Organic light-emitting diodes Deep blue em itter QUINAZOLINE CARBAZOLE Electroluminescence 
Oxidative Rearrangement of Isatins with Arylamines Using H2O2 as Oxidant： A Facile Synthesis of Quinazoline-2,4-diones and Evaluation of Their Antibacterial Activity被引量：3
《Chinese Journal of Chemistry》2017年第12期1835-1843,共9页Guanghao Shi Xinwei He Yongjia Shang Cheng Yang Liwei Xiang 
Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc,201700280 or from the author.Acknowledgement The work was partially supported by the National Natural Science Foundation of China （No. 21172001, 21372008）, the Natural Science Foundation of Education Administration of Anhui Province （KJ2016A267）, the Special and Excellent Research Fund of Anhui Normal University and the Doctoral Scientific Research Foundation of Anhui Normal University （No. 2016XJJ110）.
A green and highly efficient synthetic method for the synthesis of quinazoline-2,4-diones with hydrogen peroxide as the terminal oxidant has been developed, The reaction features the mild reaction conditions, broad su...
关键词：antibacterial activity hydrogen peroxide ISATINS quinazoline-2 4-diones rearrangement 
Regioselective Synthesis of SCF3-Substituted 2,4-Diarylquinazoline Using AgSCF3 as Trifluoromethylthiolation Reagent被引量：2
《Chinese Journal of Chemistry》2017年第11期1717-1725,共9页Wei Gao Qiuping Ding Jianjun Yuan Xuechun Mao Yiyuan Peng 
Financial support from National Natural Science Foundation of China （Nos. 21162012 and 21362014） and Key Laboratory of Functional Small Organic Mol-ecule, Ministry of Education, Jiangxi Normal University （No. KLFS-KF-201407） is gratefully acknowledged.
A facile and efficient route to 4-aryl-2-[2-（trifluoromethylthio） aryl]quinazoline derivatives through a tandem directed Rh-catalyzed C-H iodination and trifluoromethylthiolation is described. The reaction proceeded...
关键词：2 4-diarylquinazoline trifluoromethylthiolation Rh-catalyzer AgSCF3 tandem reaction 
Synthesis, Cytotoxic Activity Evaluation of Novel 1,2,3-Triazole Linked Quinazoline Derivatives被引量：1
《Chinese Journal of Chemistry》2017年第10期1633-1639,共7页Panpan Song Fei Cui Na Li Jingchao Xin Qisheng Ma Xiangchuan Meng Chaojie Wang Qinpo Cao Yifei Gu Yu Ke Qiurong Zhang Hongmin Liu 
A series of novel 1,2,3-triazole-quinazoline derivatives were synthesized in five steps starting from anthranila- mide by conventional methods. All the title compounds 10a-10r were evaluated for cytotoxic activity aga...
关键词：QUINAZOLINE TRIAZOLE SYNTHESIS CYTOTOXICITY 
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