STAPLING

作品数：26被引量：61H指数：4
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A high-performance degradable Mg alloy suturing staple for single-arm oral stapling robot被引量：1
《Journal of Magnesium and Alloys》2024年第10期4096-4118,共23页Q.H.Wang S.S.Liang F.S.Yuan B.Y.Liu J.Z.Yu W.Wang N.Fakhar H.X.Li 
supported by the National Key R&D Program of China(grant number:2020YFB1312801);the National Natural Science Foundation of China(No.51971020,No.52171097);the Opening Research Fund of State Key Laboratory for Advanced Metals and Materials(2021-Z08);the Fundamental Research Funds for the Central Universities(grant number:PKU2022XGK005);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2022-JKCS-24);the Key Scientific Research Project in Shanxi Province(202102050201003);the“Dingxinbeike”Project(G20200001105).
Minimally invasive surgery(MIS)robots,such as single-arm stapling robots,are key to oral and maxillofacial surgery because they overcome space constraints in the oral cavity and deep throat.However,biodegradable sutur...
关键词：Biodegradable Mg alloy Suture staples Mechanical properties Micro-galvanic corrosion Biocompatibility. 
Clinical diagnostic advances in intestinal anastomotic techniques:Hand suturing,stapling,and compression devices被引量：1
《World Journal of Gastrointestinal Surgery》2024年第5期1231-1234,共4页Ah Young Lee Joo Young Cho 
The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical practice.These methods aim to prevent leakage and minimi...
关键词：ANASTOMOSES Diagnostic advances Anastomotic techniques Technique Intestine 
Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice被引量：2
《Acta Pharmaceutica Sinica B》2023年第9期3770-3781,共12页Wei Cong Huaxing Shen Xiufei Liao Mengjun Zheng Xianglong Kong Zhe Wang Si Chen Yulei Li Honggang Hu Xiang Li 
supported by Shanghai Rising-Star Program(to Xiang Li);the National Nature Science Foundation of China No.21807112(to Xiang Li),No.91849129(to Honggang Hu),No.22077078(to Honggang Hu)and No.22207065(to Yulei Li);academic promotion program of Shandong First Medical University(No 2019LJ003,China,to Yulei Li);Taishan Scholars Program(to Yulei Li)。
Stapled peptides with significantly enhanced pharmacological profiles have emerged as promising therapeutic molecules due to their remarkable resistance to proteolysis and performance to penetrate cells.The all-hydroc...
关键词：Stapled peptides OSTEOPOROSIS Orally effective Double-stapling 
Cysteine-Specific Bioconjugation and Stapling of Unprotected Peptides by Chlorooximes
《CCS Chemistry》2022年第10期3355-3363,共9页Qingqing Chen Tengfang Long Jie Zheng Wangjian Sheng Shuaishuai Sun Wei Wei Jing Zhao Huan Wang 
supported by the National Natural Science Foundation(NSF)of China(grant nos.21922703 and 91953112);the NSF of Jiangsu Province(grant nos.BK20190004 and BK20202004);the National Key R&D Program of China(grant no.2019YFA0905800);Shenzhen Basic Research Program(grant no.JCYJ20180508-182240106);the Fundamental Research Funds for the Central Universities(grant nos.14380138 and 14380131).
Cyclic peptides have found applications in fields ranging from drug discovery to nanomaterials.Peptide stapling reagents crosslink two or more residues in peptides to generate macrocycles of diverse topology and intro...
关键词：cyclic peptides peptide stapling BIOCONJUGATION chlorooximes CYSTEINE 
Cleavable Cys labeling directed Lys site-selective stapling and single-site modification被引量：1
《Science China Chemistry》2022年第7期1356-1361,共6页Jian Li Qi-Long Hu Zhendong Song Albert S.C.Chan Xiao-Feng Xiong 
supported by Guangdong Natural Science Funds for Distinguished Young Scholar (2018B030306017);the National Natural Science Foundation of China (22077144);Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery (2019B030301005);Key Research and Development Program of Guangdong Province (2020B1111110003)。
Site-selective modification of peptide/protein is a vital approach to disclose post-translational modifications(PTMs) and plays a crucial role in chemical biology, as well as drug development. Compared with synthetic ...
关键词：LYSINE protein modification single-site modification STAPLING 
Corrigendum to“Peptide stapling with the retention of double native side-chains”[Chinese Chemical Letters 32(2021)4045-4048]
《Chinese Chemical Letters》2022年第6期3296-3296,共1页Ye Wu Yan Zou Lingling Sun Alfredo Garzino-Democ Honggang Hu Weidong Zhang Xiang Li 
The authors regret having incorrectly labelled the molar concentration of 1^(st)Grubbs'catalyst in Fig.3B.The original manuscript illustrates molar concentration of 1^(st)Grubbs'catalyst at 6 mol/L.This should have be...
关键词：MOLAR catalyst CHAINS 
Bicyclic stapled peptides based on p53 as dual inhibitors for the interactions of p53 with MDM2 and MDMX
《Chinese Chemical Letters》2022年第3期1254-1258,共5页Hongjin Li Xiangyan Chen Minghao Wu Panpan Song Xia Zhao 
supported by National Natural Science Foundation of China-Shandong Joint Fund (No. U1606403);Innovation Project of Qingdao National Laboratory for Marine Science and Technology (No. 2015ASKJ02)。
In recent years, the strategy of inhibiting the interactions of p53 with murine double minute 2(MDM2)and murine double minute X(MDMX) has been proved to be a promising approach for tumor therapy.However, the poor prot...
关键词：P53 MDM2 MDMX All-hydrocarbon stapling strategy Lactam stapling strategy Bicyclic stapling strategy 
Peptide stapling with the retention of double native side-chains被引量：1
《Chinese Chemical Letters》2021年第12期4045-4048,共4页Ye Wu Yan Zou Lingling Sun Alfredo Garzino-Demo Honggang Hu Weidong Zhang Xiang Li 
supported by the National Key R&D Program of China (No. 2019YFC1711000, to X. Li);the National Nature Science Foundation of China (No. 21807112, to X. Li;No. 91849129, to H. Hu;No. 22077078, to H. Hu);Shanghai Rising-Star Program (to X. Li)。
All-hydrocarbon stapling strategy has been widely applied for enhancing the proteolytic stability of peptides. However, two major technical hurdles to some extent limit the development of stapled peptides for therapeu...
关键词：Stapling strategy Stapled peptide Native side chain Peptide drug design HIV-1 fusion inhibitor SC34EK 
Structural modification and antitumor activity of antimicrobial peptide HYL被引量：4
《Chinese Chemical Letters》2020年第5期1288-1292,共5页Minghao Wu Qing Chen Yingdi Wang Yulei Li Xia Zhao Qi Chang 
supported by NSFC-Shandong Joint Fund(No.U1606403);Innovation Project of Qingdao National Laboratory for Marine Science and Technology(No.2015ASKJ02)。
HYL derived from the venom of the solitary bee Hylaeus signatus(Hymenoptera:Colletidae)is anα-helical antimicrobial peptide with 16 residues.To explore whether HYL can be applied in anti-tumor therapy,we synthesized ...
关键词：HYL α-Helical peptide Stapled peptide Hydrocarbon stapling strategy Antitumor activity Solid-phase synthesis 
Incidence of anastomotic stricture after Ivor-Lewis oesophagectomy using a circular stapling device
《World Journal of Gastrointestinal Surgery》2019年第11期407-413,共7页Robert Tyler Amit Nair Meagan Lau James Hodson Rizwan Mahmood Jan Dmitrewski 
BACKGROUND Benign oesophageal strictures carry a significant level of morbidity,causing burdensome symptoms impacting on quality of life.Post-oesophagectomy anastomotic stricture rates as high as 41%have been reported...
关键词：OESOPHAGEAL cancer ANASTOMOSIS STRICTURE Stapled CIRCULAR 
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