DELETIONS

作品数：44被引量：107H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：饶秋夏秋媛姜泗长戴朴韩东一更多>>
相关机构：南京军区南京总医院中国人民解放军总医院北京市眼科研究所南通大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家科技部专项基金国家科技支撑计划更多>>
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A highly efficient method for genomic deletion across diverse lengths in thermophilic Parageobacillus thermoglucosidasius
《Synthetic and Systems Biotechnology》2024年第4期658-666,共9页Zhiheng Yang Bixiao Li Ruihong Bu Zhengduo Wang Zhenguo Xin Zilong Li Lixin Zhang Weishan Wang 
supported by the National Key Research and Development Program of China(2020YFA0907800);the National Natural Science Foundation of China(32170095 and 32100066);the Youth Innovation Promotion Association CAS(Y202027)to W.W.
Parageobacillus thermoglucosidasius is emerging as a highly promising thermophilic organism for metabolic engineering.The utilization of CRISPR-Cas technologies has facilitated programmable genetic manipulation in P.t...
关键词：Type I CRISPR system Thermostable NHEJ enzymes THERMOPHILE Long-range genomic deletions 
Amino acid deletions at positions 893 and 894 of cytotoxinassociated gene A protein affect Helicobacter pylori gastric epithelial cell interactions被引量：1
《World Journal of Gastroenterology》2024年第41期4449-4460,共12页Zhi-Jing Xue Ya-Nan Gong Li-Hua He Lu Sun Yuan-Hai You Dong-Jie Fan Mao-Jun Zhang Xiao-Mei Yan Jian-Zhong Zhang 
Supported by the Shandong Medical and Health Science and Technology Development Plan Project,No.202202080452.
BACKGROUND Helicobacter pylori(H.pylori)persistently colonizes the human gastric mucosa in more than 50%of the global population,leading to various gastroduodenal diseases ranging from chronic gastritis to gastric car...
关键词：Cytotoxin-associated gene A Glu-Pro-Ile-Tyr-Ala Hummingbird phenotype INTERLEUKIN-8 Helicobacter pylori 
Molecular mechanisms of DNA lesion and repair during antibody somatic hypermutation
《Science China(Life Sciences)》2024年第11期2344-2353,共10页Qian Hao Jinfeng Li Leng-Siew Yeap 
supported by the National Key Research and Development Program of China(2021YFA1301400);the National Natural Science Foundation of China(32370934);the Shanghai Jiao Tong University 2030 Initiative(2030-B23).
Antibody diversification is essential for an effective immune response,with somatic hypermutation(SHM)serving as a key molecular process in this adaptation.Activation-induced cytidine deaminase(AID)initiates SHM by in...
关键词：somatic hypermutation(SHM) insertions and deletions(indels) AID base excision repair(BER) mismatch repair(MMR) translesion synthesis(TLS)polymerases 
Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions
《Genes & Diseases》2024年第5期40-43,共4页Konstantin Deutsch Verena Klambt Thomas M.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif El Desoky Jameela A.Kari Farkhanda Hafeez Maria Szczepanska Loai A.Eid Hazem S.Awad Muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca M.Schierbaum Sophia Schneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg Shirlee Shril Shrikant M.Mane Nancy Rodig Friedhelm Hildebrandt 
The Deutsche Forschungsgemeinschaft funded V.K.(No.403877094);S.Se(No.442070894)and T.J.S.(No.281319475);V.K.was also funded by the Else-Kroner Fresenius Stiftung(Memorial Grant);the BIH ChariteClinician Scientist Program by the Charite´e Universitatsmedizin Berlin,and the Berlin Institute of Health at Charite.S.Se.was supported by the Deutsche Forschungsgemeinschaft(German Research Foundation)lT.M.K.was also supported by a Post-Doctoral Fellowship award from the KRESCENT Program,a national kidney research training partnership of the Kidney Foundation of Canada,the Canadian Society of Nephrology,and the Canadian Institutes of Health Research.T.J.-S.received funding from the IZKF Erlangen(J70)and the Eva Luise und Horst Kohler Stiftung/Else Kroer-Fresenius Stiftung(RECORD program).
Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 ...
关键词：DEGENERATION URINARY LIKELY 
An expectation–maximization algorithm for estimating proportions of deletions among bacterial populations with application to study antibiotic resistance gene transfer in Enterococcus faecalis被引量：2
《Marine Life Science & Technology》2023年第1期28-43,共16页Yu Zhang Cong Zhang Wenwen Huo Xinlei Wang Michael Zhang Kelli Palmer Min Chen 
This work was supported by the National Institutes of Health[Grant R15GM131390 to X.W.,Grant R01CA245294 to M.Z.,and Grant R01AI116610 to K.P.]。
The emergence of antibiotic resistance in bacteria limits the availability of antibiotic choices for treatment and infection control,thereby representing a major threat to human health.The de novo mutation of bacteria...
关键词：Bacterial genomes CRISPR-Cas system Antibiotic resistance EM algorithm Proportion estimation 
Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells被引量：1
《Journal of Genetics and Genomics》2022年第10期927-933,共7页Siyu Chen Zhiquan Liu Hao Yu Liangxue Lai Zhanjun Li 
supported by the National Key Research and Development Program of China Stem Cell and Translational Research(2019YFA0110700);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_16R32);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030501,XDA16030503);Key Research&Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110104004)。
CRISPR/Cas9 system is a robust genome editing platform in biotechnology and medicine.However,it generally produces small insertions/deletions(indels,typically 1-3 bp)but rarely induces larger deletions in specific tar...
关键词：CRISPR/Cas9 DEAMINASE C-DEL A-DEL 
Influence of high-molecular-weight glutenin subunit deletions at the Glu-A1 and Glu-D1 loci on protein body development, protein components and dough properties of wheat(Triticum aestivum L.)被引量：1
《Journal of Integrative Agriculture》2022年第7期1867-1876,共10页LIU Da-tong ZHANG Xiao JIANG Wei LI Man WU Xu-jiang GAO De-rong BIE Tong-de LU Cheng-bin 
supported by the National Key Research and Development Program of China(2016YFD0100500);the Natural Science Foundation of Jiangsu Province,China(BK20160448);the National Natural Science Foundation of China(32071999 and 31700163)。
High-molecular-weight glutenin subunits(HMW-GSs) play a critical role in determining the viscoelastic properties of wheat. As the organelle where proteins are stored, the development of protein bodies(PBs) reflects th...
关键词：WHEAT near-isogenic lines HMW-GS deletion protein body dough property 
A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro被引量：5
《Virologica Sinica》2021年第5期1052-1065,共14页Pengfei Chen Xiongwei Zhao Shuting Zhou Tianxing Zhou Xiangmei Tan Xia Wu Wu Tong Fei Gao Lingxue Yu Yifeng Jiang Hai Yu Zhibiao Yang Guangzhi Tong Yanjun Zhou 
supported by the National Program on Key Research Project of China(2016YFD0500100);the Shanghai Youth Scientific and Technological Yang Fan Program Grant(20YF1457800);the National Natural Science Foundation of China(31472207);the earmarked fund for Modern Agro-industry Technology Research System of China(CARS-36);the China Postdoctoral Science Foundation(2020M670555);Shanghai Minhang District talent development special funds。
Highly virulent porcine epidemic diarrhea virus(PEDV)strains re-emerged and circulated in China at the end of 2010,causing significant economic losses in the pork industry worldwide.To understand the genetic dynamics ...
关键词：Porcine epidemic diarrhea virus(PEDV) Serially passage Genetic variation Pathogenicity 
Adapt or perish:SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain
《Signal Transduction and Targeted Therapy》2021年第5期1416-1417,共2页Marta Ribes Carlos Chaccour Gemma Moncunill 
M.R.and C.Ch.received salary support from Unitaid through the BOHEMIA grant to ISGlobal.ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the“Centro de Excelencia Severo Ochoa 2019-2023”Program(CEX2018-000806-S);support from the Generalitat de Catalunya through the CERCA Program.
In a recent report in Science,McCarthy et al.promptly observed a pattern of recurrent deletions in four discrete regions of the N-terminal Domain(NTD)of the Spike protein,which provide resistance to antibody neutraliz...
关键词：al. PROMPT Domain 
Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape被引量：6
《四川生理科学杂志》2021年第1期86-86,共1页Kevin R McCarthy 
Zoonotic pandemics,like that caused by SARS-CoV-2,can follow the spillover of animal viruses into highly susceptible human populations.Their descendants have adapted to the human host and evolved to evade immune press...
关键词：GLYCOPROTEIN OVERCOME slowly 
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