STEREOISOMERISM

作品数：6被引量：8H指数：2
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相关领域：理学更多>>
相关作者：曾苏周权姚彤炜更多>>
相关机构：浙江大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金更多>>
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Is the required therapeutic effect always achieved by racemic switch of proton-pump inhibitors?被引量：4
《World Journal of Gastroenterology》2008年第16期2617-2619,共3页Quan Zhou Xiao-Feng Yan Wen-Sheng Pan Su Zeng 
Supported by Zhejiang Provincial Bureau of Education, No. 20070227;Zhejiang Medical Association, No.2007ZYC18;Association of Zhejiang Hospital Administration, No. 2007AZHA-KEB312
Many of the drugs currently used in medical practice are racemates. The enantiomers of a racemic drug differ in pharmacodynamics and/or pharmacokinetics, thus in some cases it is preferable to develop pure enantiomers...
关键词：Proton-pump inhibitors ENANTIOMER RACEMATE STEREOISOMERISM Racemic switch Pharmacokinetics PHARMACODYNAMICS Cytochrome P450 Genotype 
Pharmacokinetic difference between S-(+)- and R-(-)-etodolac in rats
《Acta Pharmacologica Sinica》2004年第8期996-999,共4页Jing-minSHI Shun-guoLAI Chang-jiangXU Geng-liDUAN DuanLI 
AIM: To study whether etodolac enantiomers have pharmacokinetic difference after oral administration. METHODS: Fourteen rats, divided into two groups randomly, were orally given S-(+)- or R-(-)-etodolac at a single do...
关键词：ETODOLAC non-steroidal anti-inflammatory agents PHARMACOKINETICS STEREOISOMERISM 
(-)Epicatechin induces and modulates endothelium-dependent relaxation in isolated rat mesenteric artery rings
《Acta Pharmacologica Sinica》2002年第12期1188-1192,共5页ChenZY YaoXQ 
AIM: The present study was aimed to examine the role of endothelial nitric oxide in the relaxant response to green tea (-)epicatechin and its modulation of endothelium-mediated relaxation in the isolated rat mesenteri...
关键词：Animals CATECHIN Endothelium  Vascular In Vitro Male Mesenteric Arteries Methylene Blue Muscle  Smooth  Vascular NG-Nitroarginine Methyl Ester Nitric Oxide Synthase PHENYLEPHRINE RATS Rats  Sprague-Dawley Research Support  Non-U.S. Gov't STEREOISOMERISM Tea VASODILATION 
Effects of stereochemical aspects on drug interaction in pharmacokinetics
《Acta Pharmacologica Sinica》2002年第5期385-392,共8页周权 姚彤炜 曾苏 
Recent literatures on enantiomer/enantiomer and enantiomer/coadministered drug interactions in pharmaco-kinetics were reviewed. The clinical significance of introducing the concept of stereoselectivity into pharma-cok...
关键词：STEREOISOMERISM drug interactions PHARMACOKINETICS 
A Theoretical Study on the Stereoisomerism in the Complex of Cucurbit[8]uril with 2,6-Bis(4,5-dihydro-1H-imidazol-2-yl)naphthalene被引量：1
《Chinese Chemical Letters》2001年第9期783-786,共4页Ting Wei MU Lei LIU Ke Chun ZHANG Qing Xiang GUO 
Semiempirical PM3 and density function theory B3LYP/3-21g* calculations in vacuum and in water indicated that the 'syn' orientation was preferred in the 1:2 complex of cucurbit[8]uril with protonated 2, 6-bis(4, 5-dih...
关键词：CUCURBITURILS inclusion complexation PM3 B3LYP pi-pi stacking 
Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers被引量：3
《World Journal of Gastroenterology》2001年第6期830-835,共6页Quan Zhou~(1,2) Tong-Wei Yao~1 Su Zeng~1 1 College of Pharmaceutical Sciences2 Second Hospital of Medical School,Zhejiang University,Hangzhou 310031,Zhejiang Province,China 
Supported by the National Natural Science Foundation of China(No.39370805,N039770868);Zhejiang Natural Science Foundation(No.RC97016)of Zhejiang Province
AIM: To study the influence of inducers of drug metabolism enzyme, beta-naphthoflavone (BNF) and dexamethasone (DEX), on the stereoselective metabolism of propafenone in the rat hepatic microsomes. METHODS: Phase I me...
关键词：Animals Anti-Arrhythmia Agents Dexamethasone Male Microsomes  Liver PROPAFENONE RATS Rats  Sprague-Dawley Research Support  Non-U.S. Gov't STEREOISOMERISM beta-Naphthoflavone 
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