IMMUNOMODULATION

作品数：259被引量：1340H指数：16
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相关作者：龚明玉商亚珍李素婷周晓霞王宝元更多>>
相关机构：武汉大学承德医学院南京医科大学南京大学更多>>
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Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants
《Bioactive Materials》2024年第12期404-432,共29页Siqi Jin Yameng Yu Ting Zhang Daping Xie Yufeng Zheng Chunming Wang Yunsong Liu Dandan Xia 
supported by the National Key Research and Development Program of China(2023YFC2412600);the National Natural Science Foundation of China(52271243,52171233,82370924);the NSFC-RFBR Joint Research Scheme(82361138575);the Beijing Nova Program(20230484459);the Beijing Natural Science Foundation(7242173);the Clinical Medicine Plus X-Young Scholars Project of Peking University;the Fundamental Research Funds for the Central Universities(PKU2024LCXQ014).
Soft tissue seal around the transmucosal region of dental implants is crucial for shielding oral bacterial invasion and guaranteeing the long-term functioning of implants.Compared with the robust periodontal tissue ba...
关键词：Surface modifications Dental implant transmucosal region Soft tissue seal ANTIBACTERIAL IMMUNOMODULATION 
Deciphering 3D periodontal fibroblast-macrophage crosstalk in bioactive nanoparticle-guided immunomodulation for treating traumatic dental avulsion
《Bioactive Materials》2024年第11期400-412,共13页Hadagalu Revana Siddappa Rajeshwari Emily Bishop Aiman Ali Anil Kishen 
American Association of Endodontists Foundation(#1208771);Natural Sciences and Engineering Research Council of Canada(Discovery grant)(AK-RGPIN-2020-05844);Canada Research Chair Program,and Dr.Lloyd and Mrs.Kay Chapman Chairship.
Prolonged extra-oral period in dental avulsion is often associated with loss of viability of Periodontal fibroblasts (PDLF) and increased risk of ankylosis. Root surface treatment with bioactive agents to reduce the r...
关键词：Root resorption Chitosan nanoparticles IMMUNOMODULATION Periodontal fibroblasts Macrophages 
Cartilage lacuna-biomimetic hydrogel microspheres endowed with integrated biological signal boost endogenous articular cartilage regeneration被引量：1
《Bioactive Materials》2024年第11期61-82,共22页Hao Li Tianyuan Zhao Zhiguo Yuan Tianze Gao Yongkang Yang Runmeng Li Qinyu Tian Peifu Tang Quanyi Guo Licheng Zhang 
Beijing Natural Science Foundation(L234024);Natural Science Foundation of China(82272481,323B2043);National Key R&D Program of China(2023YFB4605800).
Despite numerous studies on chondrogenesis,the repair of cartilage—particularly the reconstruction of cartilage lacunae through an all-in-one advanced drug delivery system remains limited.In this study,we developed a...
关键词：Microfluidic technology Hydrogel microsphere IMMUNOMODULATION CHONDROGENESIS Articular cartilage regeneration 
Treatment of hemophilic arthropathy by immunomodulatory extracellular vesicle delivered by liposome hybrid nanoparticles
《Bioactive Materials》2024年第10期47-63,共17页Dong Wang Wenzhe Chen Jiali Chen Du He Yanli Pan Pinger Wang Qinghe Zeng Mancang Gu Peijian Tong Di Chen Hongting Jin 
supported by the Zhejiang Provincial Natural Science Foundation of China(LR23H270001 and LQ22H270006);National Natural Science Foundation of China(82274280 and 82305005).
In individuals afflicted with hemophilia,characterized by a deficiency of coagulation factor VIII(FVIII),the occurrence of spontaneous recurrent intra-articular hemorrhage precipitates the emergence of hemophilic arth...
关键词：Hemophilic arthropathy Extracellular vesicles Recombinant factor VIII IMMUNOMODULATION CARTILAGE 
Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization被引量：2
《Bioactive Materials》2024年第6期185-202,共18页Hayeon Byun Yujin Han Eunhyung Kim Indong Jun Jinkyu Lee Hyewoo Jeong Seung Jae Huh Jinmyoung Joo Su Ryon Shin Heungsoo Shin 
supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.RS-2023-00207746,RS-2023-00207983);a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI);funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HI19C075300).
Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization.Here,we propose a multi-functional composite hydrogel engineered to overcome such conditions through...
关键词：IMMUNOMODULATION Wound healing NEOVASCULARIZATION Multi-functional nanoparticles Composite hydrogels 
Controlled-release hydrogel loaded with magnesium-based nanoflowers synergize immunomodulation and cartilage regeneration in tendon-bone healing被引量：4
《Bioactive Materials》2024年第6期62-82,共21页Jintao Li Haolin Ke Xiangcheng Lei Jiexin Zhang Zhicheng Wen Zhisheng Xiao Huabin Chen Juncheng Yao Xuan Wang Zhengnong Wei Hongrui Zhang Weilun Pan Yan Shao Yitao Zhao Denghui Xie Chun Zeng 
supported by the National Natural Science Foundation of China[grant numbers:82302639,81974327,81974328 and 82372358];National Students’Platform for Innovation and Entrepreneurship Training Program of China[grant number:No.202212121004];Natural Science Funds for Distinguished Young Scholar of Guangdong province[grant number:2022B1515020044];the Natural Science Foundation of Guangdong Province[grant number:2022A1515011101].
Tendon-bone interface injuries pose a significant challenge in tissue regeneration,necessitating innovative approaches.Hydrogels with integrated supportive features and controlled release of therapeutic agents have em...
关键词：Magnesium Metal-phenolic networks Self-assembly process Controlled release IMMUNOMODULATION Tendon-bone interface 
Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy
《Bioactive Materials》2024年第4期204-220,共17页Pei-Lin Li Da-Fu Chen Xiao-Tong Li Rui-Cong Hao Zhi-Dong Zhao Zhi-Ling Li Bo-Feng Yin Jie Tang Yu-Wen Luo Chu-Tse Wu Jing-Jun Nie Heng Zhu 
supported by the National Key R&D Program of China(Nos.2022YFA1104100,2022YFA1103500,2022YFB3804400);the National Natural Sciences Grants China(Nos.82172388,82372373,81871771,52373128,52273121);the Beijing Natural Sciences Foundation(Nos.7222123,L212065,7222011);the Beijing Municipal Health Commission(Nos.BMHC-2021-6,BJRITO-RDP-2023).
Skeletal stem cells(SSC)have gained attentions as candidates for the treatment of osteoarthritis due to their osteochondrogenic capacity.However,the immunomodulatory properties of SSC,especially under delivery operati...
关键词：Microgel carriers Skeletal stem cells Immunomodulation reprogram Single-cell RNA sequence Osteoarthritis 
In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity被引量：1
《Bioactive Materials》2024年第2期12-27,共16页Zhongda Lin Fanqiang Meng Yumeng Ma Chi Zhang Zhirang Zhang Zhaoxin Yang Yuan Li Linlin Hou Yuzhong Xu Xin Liang Xudong Zhang 
supported by grants from Shenzhen Science and Technology Program(Grant No.RCYX20200714114643121);The National Natural Science Foundation of China(31971268,32201084,32371425);Science,Technology&Innovation Commission of Shenzhen Municipality(JCYJ20200109142610136,JCYJ20180507181654186,ZDSYS20220606100803007);Guangdong Basic and Applied Basic Research Foundation(2019A1515010855,2020A1515110166);the Natural Science Foundation of Guangdong Province(No.2020A1515010802,No.2022A1515012289);University of Chinese Academy of Sciences-Shenzhen Hospital Research Funding(HRF-2020004);the Health system scientific research project of Shenzhen Guangming District Science and innovation Bureau(2020R01073,2020R01061);Fundamental Research Funds for the Central Universities(19lgzd453);Special fund for economic development of ShenZhen Guangming District(2021R01128);Doctoral personnel scientific research start-up Fund project of Guangdong Medical University(GDMUB2022037).
Immune checkpoint blockade(ICB)therapy potently revives T cell’s response to cancer.However,patients suffered with tumors that had inadequate infiltrated immune cells only receive limited therapeutic benefits from IC...
关键词：SALMONELLA GM-CSF IL-7 Synthetic biology Cancer immunotherapies 
A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment被引量：1
《Bioactive Materials》2024年第2期206-221,共16页Valentina Marotti Yining Xu Cécilia Bohns Michalowski Wunan Zhang Inês Domingues Hafsa Ameraoui Tom G.Moreels Pieter Baatsen Matthias Van Hul Giulio G.Muccioli Patrice D.Cani Mireille Alhouayek Alessio Malfanti Ana Beloqui 
Belgian F.R.S.-FNRS(Fonds de la recherche scientifique)under grants WELBIO-CR-2022A-02;The Excellence Of Science(EOS:program no.EOS 30770923 and 40007505);supported by the Marie Skłodowska-Curie Actions for an Individual European Fellowship under the European Union’s Horizon 2020 research and innovation program(grant agreement no.887609);by a FRS-FNRS fellowship(grant agreement no.40000747)(Belgium);partially supported by the FRS-FNRS(convention T.0013.19);FRFS-WELBIO,with the support of the Wallon region(under grant agreement WELBIO-CR-2022 S-01);has received funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(grant agreement No.850997-NanoGut).
Current treatments for inflammatory bowel disease(IBD)treatment consist of anti-inflammatory products.In this study,we sought to induce the physiological secretion of glucagon-like peptide 2,a peptide with intestinal ...
关键词：NANOCARRIER GLP-2 Teduglutide KPV Inflammatory bowel disease 
Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation被引量：3
《Bioactive Materials》2023年第10期95-111,共17页Pu Luo Ruoxuan Huang You Wu Xingchen Liu Zhengjie Shan Li Gong Shudan Deng Haiwen Liu Jinghan Fang Shiyu Wu Xiayi Wu Quan Liu Zetao Chen Kelvin W.K.Yeung Wei Qiao Shoucheng Chen Zhuofan Chen 
supported by National Natural Science Foundation of China(82071167,82001095,81970975,81901055,82201124,82201119);China Postdoctoral Science Foundation(2021TQ0379,2022M713575);Guangdong Basic and Applied Basic Research Foundation(2021A1515110380,2023A1515011963);Health and Medical Research Fund(No.09201466);the Food and Health Bureau,the Government of the HKSAR,China.
With the discovery of the pivotal role of macrophages in tissue regeneration through shaping the tissue immune microenvironment, various immunomodulatory strategies have been proposed to modify traditional biomaterial...
关键词：Wound healing Decellularized extracellular matrix Freeze-thaw treatment Multiscale mechanics Macrophage polarization IMMUNOMODULATION MECHANOTRANSDUCTION 
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