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CHECKPOINT: 作品数：720被引量：1395H指数：15; 导出分析报告; 相关领域：医药卫生自动化与计算机技术更多>>; 相关作者：段红刘穆进张彩田志刚景年财更多>>; 相关机构：上海大学华中科技大学国防科学技术大学CheckPoint软件技术有限公司更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金国家重点基础研究发展计划更多>>

Unlocking the potential of immunotherapy in platinum-resistant ovarian cancer:rationale,challenges,and novel strategies: 《Cancer Drug Resistance》2024年第1期309-331,共23页Joanna Kefas Michael Flynn; Ovarian cancer is a significant global health challenge,with cytoreductive surgery and platinum-based chemotherapy serving as established primary treatments.Unfortunately,most patients relapse and ultimately become pl...; 关键词：Ovarian cancer IMMUNOTHERAPY immune checkpoint inhibition immunotherapy resistance

Current applications of tumor local ablation(TLA)combined with immune checkpoint inhibitors in breast cancer treatment: 《Cancer Drug Resistance》2024年第1期439-458,共20页Lingpeng Tang Dandan Wang Ting Hu Xiaoying Lin Songsong Wu; supported by the Fujian Science and Technology Innovation Joint Funding Program(No.2023Y9332).; Breast cancer is one of the most common cancers in women globally,posing significant challenges to treatment because of the diverse and complex pathological and molecular subtypes.The emergence of immune checkpoint in...; 关键词：Tumor microenvironment antitumor immune response ablation immune checkpoint inhibitors

The evolving role of immune checkpoint inhibitors in cervical and endometrial cancer: 《Cancer Drug Resistance》2024年第1期644-660,共17页Bertha Alejandra Martinez-Cannon Ilaria Colombo; The introduction of immune checkpoint inhibitors(ICIs)has revolutionized the treatment landscape for numerous tumor types,including cervical and endometrial cancers.Multiple ICIs against programmed cell death-1(PD-1),...; 关键词：IMMUNOTHERAPY cervical cancer endometrial cancer immune checkpoint inhibitors

Overcoming immuno-resistance by rescheduling anti-VEGF/cytotoxics/anti-PD-1 combination in lung cancer model: 《Cancer Drug Resistance》2024年第1期910-924,共15页Guillaume Sicard Dorian Protzenko Sarah Giacometti Fabrice Barlési Joseph Ciccolini Raphaelle Fanciullino; supported by A^(*)midex Foundation-initiative d’Excellence and the Aix-Marseille Université。; Background:Many tumors are refractory to immune checkpoint inhibitors,but their combination with cytotoxics is expected to improve sensitivity.Understanding how and when cytotoxics best re-stimulate tumor immunity cou...; 关键词：Immune checkpoint inhibitors CISPLATIN PEMETREXED ANTI-VEGF non-small cell lung cancer efficacy study immunomonitoring

Exploring resistance to immune checkpoint inhibitors and targeted therapies in melanoma: 《Cancer Drug Resistance》2024年第1期249-272,共24页Anum Jalil Melissa M Donate Jane Mattei; Melanoma is the most aggressive form of skin cancer,characterized by a poor prognosis,and its incidence has risen rapidly over the past 30 years.Recent therapies,notably immunotherapy and targeted therapy,have signifi...; 关键词：IMMUNOTHERAPY BRAF RESISTANCE MELANOMA overcoming resistance

Mechanisms of tyrosine kinase inhibitor resistance in renal cell carcinoma被引量：3: 《Cancer Drug Resistance》2023年第4期858-873,共16页Patrick L.Sweeney Yash Suri Arnab Basu Vadim S.Koshkin Arpita Desai; Renal cell carcinoma(RCC),the most prevalent type of kidney cancer,is a significant cause of cancer morbidity and mortality worldwide.Antiangiogenic tyrosine kinase inhibitors(TKls),in combination with immune checkpoi...; 关键词：Antiangiogenic tyrosine kinase inhibitors renal cell carcinoma acquired resistance SUNITINIB tumor microenvironment immune checkpoint inhibitors

Immune checkpoint inhibitors in breast cancer: development, mechanisms of resistance and potential management strategies被引量：1: 《Cancer Drug Resistance》2023年第4期768-787,共20页Rachel SJ Wong Rebecca JM Ong Joline SJ Lim; JSJ Lim is supported by the NMRC(NMRC/MOH/00414).All other authors have no funding to declare.; The use of immune checkpoint inhibitors(iCls)has increased exponentially in the past decade,although its progress specifically for breast cancer has been modest.The first U.S.Food and Drug Administration approval for ...; 关键词：IMMUNOTHERAPY immune checkpoint inhibitors resistance mechanisms breast cancer

Primary and acquired resistance to first-line therapy for clear cell renal cell carcinoma被引量：3: 《Cancer Drug Resistance》2023年第3期517-546,共30页Serena Astore Giulia Baciarello Linda Cerbone Fabio Calabrò; The introduction of first-line combinations had improved the outcomes for metastatic renal cell carcinoma (mRCC) compared to sunitinib. However, some patients either have inherent resistance or develop resistance as a...; 关键词：Renal cell carcinoma RESISTANCE tumor microenvironment checkpoint inhibitors target therapy

Emerging resistance vs. losing response to immune check point inhibitors in renal cell carcinoma: two differing phenomena: 《Cancer Drug Resistance》2023年第3期642-655,共14页Arya Mariam Roy Saby George; The introduction of immune checkpoint inhibitor (ICI) has revolutionized the treatment of metastatic renal cell carcinoma (mRCC) and has dramatically improved the outcomes of patients. The use of monotherapy or combin...; 关键词：Renal cell carcinoma immunotherapy immune checkpoint inhibitors primary resistance acquired resistance immune exhaustion markers immunosuppressive tumor microenvironment

A review of strategies to overcome immune resistance in the treatment of advanced prostate cancer: 《Cancer Drug Resistance》2023年第3期656-673,共18页Kenneth Sooi Robert Walsh Nesaretnam Kumarakulasinghe Alvin Wong Natalie Ngoi; Immunotherapy has become integral in cancer therapeutics over the past two decades and is now part of standard-of-care treatment in multiple cancer types. While various biomarkers and pathway alterations such as dMMR,...; 关键词：Prostate cancer IMMUNOTHERAPY immune checkpoint inhibitor immune resistance tumour microenvironment

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