IMMUNOSTIMULATORY

作品数：24被引量：33H指数：3
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相关领域：医药卫生更多>>
相关机构：中国农业科学院兰州兽医研究所更多>>
相关期刊：《Journal of Wuhan University of Technology(Materials Science)》《Acta Pharmacologica Sinica》《Wuhan University Journal of Natural Sciences》《Food and Nutrition Sciences》更多>>
相关基金：国家自然科学基金北京市自然科学基金国家教育部博士点基金国家重点基础研究发展计划更多>>
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An aptamer-driven DNA nanodevice for improved delivery of synthetic immunostimulants
《Nano Research》2024年第10期9078-9083,共6页Dejie Lu Zhenghan Di Lele Li Jian Zhao Li Zheng 
supported financially by the National Natural Science Foundation of China(Nos.T2322005 and 32101156);Youth Innovation Promotion Association CAS.
Efficient delivery of therapeutics to immune cells remains a formidable challenge for cancer immunotherapy.In this work,we demonstrate that an aptamer-driven DNA nanodevice,constructed through linkage of a synthetic i...
关键词：APTAMER immunostimulatory oligonucleotides DNA nanodevice tumor-associated macrophages cancer therapy 
Immunostimulatory CKb11 gene combined with immune checkpoint PD-1/PD-L1 blockade activates immune response and simultaneously overcomes the immunosuppression of cancer
《Bioactive Materials》2024年第9期239-254,共16页Wen Nie Yihong He Xue Mi Shi He Jing Chen Yunchu Zhang Bilan Wang Songping Zheng Zhiyong Qian Xiang Gao 
supported by Sichuan Science and Technology Program(No.2023YFS0170,2023NSFSC1931);supported by Medical Science and Technology Project of Sichuan Provincial Health Commission(No.21PJ009);supported by the National Natural Science Foundation of China(No.32222046,32371545,82103635);supported by the Technological innovation research and development project of Chengdu Science and Technology Bureau(2022-YF05-01589-SN);The 1⋅3⋅5 project of excellent development of discipline of West China Hospital of Sichuan University(No.ZYGC21022).
Immunosuppression tumor microenvironment(TME)seriously impedes anti-tumor immune response,resulting in poor immunotherapy effect of cancer.This study develops a folate-modified delivery system to transport the plasmid...
关键词：Ovarian cancer Immunogene therapy CKb11 Immune checkpoint PD-1/PD-L1 NANOMEDICINE 
Convergent synthesis and immunological study of oligosaccharide derivatives related to galactomannan from Antrodia cinnamomea
《Chinese Chemical Letters》2024年第5期155-160,共6页Shuying Li Weiwei ZhuGe Xuan Sun Chongzhen Sun Zhaojun Liu Chenghe Xiong Min Xiao Guofeng Gu 
supported by grants from the National Key Research and Development Program of China(No.2018YFA0902000);the National Natural Science Foundation of China(No.21877074).
The galactomannan from Antrodia cinnamomea(AC)is characterized as one of the important bioactive components that exhibits potential immunostimulatory propriety.The biological function of its corresponding oligosacchar...
关键词：Antrodia cinnamomea GALACTOMANNAN OLIGOSACCHARIDE Immunostimulatory propriety Chemical synthesis 
Immunostimulatory gene therapy combined with checkpoint blockade reshapes tumor microenvironment and enhances ovarian cancer immunotherapy被引量：2
《Acta Pharmaceutica Sinica B》2024年第2期854-868,共15页Yunzhu Lin Xiang Wang Shi He Zhongxin Duan Yunchu Zhang Xiaodong Sun Yuzhu Hu Yuanyuan Zhang Zhiyong Qian Xiang Gao Zhirong Zhang 
supported by the National Natural Science Foundation of China(Nos.32222046,82172630,82170844 and 82270613,China);the Sichuan Science and Technology Program(Nos.2022YFH0045 and 2022YFH0102,China);the 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYJC21022,China).
Immune evasion has made ovarian cancer notorious for its refractory features, making the development of immunotherapy highly appealing to ovarian cancer treatment. The immune-stimulating cytokine IL-12 exhibits excell...
关键词：IL-12encodinggene Checkpointblocker Nanoparticles Targeted delivery Tumormicroenvironment Immune escape Ovarian cancer IMMUNOTHERAPY 
Species-or genus-dependent immunostimulatory effects of gut-derived potential probiotics
《Journal of Genetics and Genomics》2023年第10期786-794,共9页Saisai Feng Shunhe Wang Dingwu Qu Jing Li Fengwei Tian Leilei Yu Hao Zhang Jianxin Zhao Wei Chen Qixiao Zhai 
supported by the National Natural Science Foundation of China(No.32122067 and No.32021005);the Natural Science Foundation of Jiangsu Province(BK20200084);the National Natural Science Foundation of China(U1903205);Collaborative innovation center of food safety and quality control in Jiangsu Province.
The immune regulatory effects of probiotics have been widely recognized to be strain-specific.However,it is unknown if there is a species-or genus-dependent manner.In this study,we use an in vitro mesenteric lymph nod...
关键词：Akkermansia muciniphila Clostridium butyricum Mesenteric lymph nodes In vitro model Species or genus responsive pattern 
Effects of rhamnogalacturonan-I type polysaccharide purified from Curcuma longa on immunostimulatory and intracellular signaling pathway mechanisms of macrophages
《Food Bioscience》2023年第3期1013-1024,共12页Seung-U Son Eun Hye Choi Kwang-Soon Shin 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF),funded by the Ministry of Education[grant number NRF-2020R1F1A1070996].
In previous study,potent anti-metastatic activities of turmeric-derived pectic polysaccharide(TP)via immune enhancing effects of intravenous and oral administration were evaluated.The present study was designed to elu...
关键词：Curcuma longa RHAMNOGALACTURONAN-I MACROPHAGE MAPK and NF-κB 
Immunostimulatory and Immunorestorative Effects of Leaf Extract and Fractions of Musanga cecropioides on Immunocompetent and Experimentally Immunocompromised Mice
《Clinical Complementary Medicine and Pharmacology》2023年第1期53-61,共9页Cyril O.Ogbue Felix A.Onyegbule Christopher O.Ezugwu Ifebi H.M.Nchekwube Amara A.Ajaghaku 
Background:Stimulation of the immune system against disease and restoration of immune functions in immun-odeficiency disease state are essential for maintaining good health.Objective:This study investigated the immuno...
关键词：Musanga cecropioides IMMUNOSTIMULATION Immunorestoration Leucopoiesis ANTIBODY 
Myeloid-derived suppressor cells in cancer
《iLIVER》2022年第2期81-89,共9页Jun Gao Wei-Ren Liu Zheng Tang Jia Fan Ying-Hong Shi 
supported by grants from the National Natural Science Foundation of China(No.81773067,82073217,82073218,and 82003084);Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX05);Shanghai Municipal Key Clinical Specialty,CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2 M-5-058);National Key R&D Program of China(2020YFE0202200).
Numerous recent studies have shown that myeloid-derived suppressor cells(MDSCs),a strongly heterogeneous population of immunosuppressive cells,are dysregulated in the presence of many cancers.MDSCs present different p...
关键词：Myeloid-derived suppressor cells IMMUNOSUPPRESSION IMMUNOSTIMULATORY Tumor microenvironment Targeted therapy 
Immunostimulatory eff ect of quaternary degree and acetyl group of quaternized chitosan on macrophages RAW 264.7
《Journal of Oceanology and Limnology》2022年第3期1160-1170,共11页Xiaomin LI Rong’e XING Chaojie XU Song LIU Yukun QIN Kecheng LI Huahua YU Pengcheng LI 
*Supported by Key Deployment Projects of the Marine Science Research Center of Chinese Academy of Sciences(No.COMS2020J04)。
Hydroxypropyltrimethyl ammonium chloride chitosan(HACC)and hydroxypropyltrimethyl ammonium chloride fully deacetylated chitosan(De-HACC)were synthesized with various degrees of substitution by altering the ratio of ch...
关键词：quaternized chitosan fully deacetylated quaternized chitosan degree of quaternization Immunostimulatory activity 
In vivo immunostimulatory effect of the amoebocyte lysate and plasma of Asian horseshoe crab,Tachypleus gigas in a piscine model
《Marine Life Science & Technology》2021年第3期355-362,共8页Sukanta Kumar Nayak Pramod Kumar Nanda Priyabrat Swain 
Antimicrobial proteins/peptides are becoming a new generation of immunostimulants for prevention and disease control in human and animals,including aquatic animals.As the haemolymph of horseshoe crabs(Tachypleus)conta...
关键词：Amoebocyte lysate IMMUNOSTIMULATORY Labeo rohita PLASMA Tachypleus gigas 
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