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AGONISTS: 作品数：136被引量：373H指数：10; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王昊刘洪瑞李智郭政东蒋华良更多>>; 相关机构：北京大学中国医科大学中国科学院北京中医药大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划SA-SIBS优秀人才奖励基金更多>>

Determination of Ten Kinds of Alpha-2 Agonists Residues in Animal Derived Food by UHPLC-Triple Quadrupole/Composite Linear Ion Trap Mass Spectrometry: 《Plant Diseases and Pests》2024年第1期28-32,共5页Fang LI Xuemei LI Xiangang LI Sining LIU Sha LIU Ying WANG; Supported by Scientific Research Project of Dalian Customs(2022DK09).; [Objectives]The paper was to establish an ultra high performance liquid chromatography-quadrupole/linear ion trap complex mass spectrometry for the determination of 10 kinds ofα2-receptor agonists in animal derived f...; 关键词：Animal derived food α_(2)-receptor agonist Solid-phase extraction Ultra-high performance liquid phase-triple quadrupole/linear ion trap composite mass spectrometry

Tropifexor,a selective non-acid farnesoid X receptor agonist,improved nonalcoholic steatohepatitis in a phase 2 trial,but several issues remain to be resolved: 《Hepatobiliary Surgery and Nutrition》2023年第5期759-762,共4页Masato Yoneda Takashi Kobayashi Naohiro Wada Tomohiro Otani Asako Nogami Michihiro Iwaki Atsushi Nakajima; As obesity continues to escalate worldwide,nonalcoholic fatty liver disease(NAFLD)has emerged as the most prevalent form of liver disease,with a reported global prevalence of 30.1%(1).The prevalence of NAFLD,which was...; 关键词：Nonalcoholic fatty liver disease(NAFLD) obesity nonalcoholic steatohepatitis(NASH) tropifexor selective non-acid farnesoid X receptor agonists(selective non-acid FXR agonists)

α/Sulfono-γ-AA peptide hybrids agonist of GLP-1R with prolonged action both in vitro and in vivo: 《Acta Pharmaceutica Sinica B》2023年第4期1648-1659,共12页Yan Shi Candy Lee Peng Sang Zaid Amso David Huang Weixia Zhong Meng Gu Lulu Wei Vân T.B.Nguyen-Tran Jingyao Zhang Weijun Shen Jianfeng Cai; supported by NIH R01AI152416(to Jianfeng Cai,USA);NIH R01 AG056569(to Jianfeng Cai,USA)。; Peptides are increasingly important resources for biological and therapeutic development,however,their intrinsic susceptibility to proteolytic degradation represents a big hurdle.As a natural agonist for GLP-1R,glucag...; 关键词：GLP-1 PEPTIDOMIMETICS Helical structures Stability Type-2 diabetes treatments Rational design GLP-1R agonists Pharmacological activity

Strigolactone agonists/antagonists for agricultural applications:New opportunities被引量：1: 《Advanced Agrochem》2022年第1期61-72,共12页Da-Wei Wang Zhen Xi; funding support by the National Natural Science Foundation of China(No.22077072 and 21837001);the Frontiers Science Center for New Organic Matter of Nankai University(No.63181206);the Haihe Laboratory of Sustainable Chemical Transformations(No.YYJC202102).; Strigolactones(SLs)are a new class of phytohormones that not only act as signalling molecules with external rhizospheric fungus and stimulate the seed germination of root parasite weeds,but also regulate many aspects ...; 关键词：STRIGOLACTONE Strigolactone agonist Strigolactone antagonist Seed germination Plant hormone

Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates: 《Acta Pharmaceutica Sinica B》2020年第6期1134-1142,共9页Qiong Xiao Minwan Hu Si Chen Yifan Tang Zeyu Shi Jing Jin Jinping Hu Ping Xie Dali Yin; financially supported by the Drug Innovation Major Project(No.2018ZX09711001-005-012,China);National Key R&D Program of China(No.2018YFC1706403);CAMS Innovation Fund for Medical Sciences(No.2016-I2M-2-002,China);Disciplines construction project(No.201920200802,China); FTY720 and IMMH002,prodrugs for sphingosine-1-phosphate receptor 1(S1P1)agonists,show inadequate and inconsistent levels of phosphorylation in humans compared to that in rats.In this study,FTY720 or IMMH002 analogues(...; 关键词：S1P1 agonist PRODRUG Catalytic amination Phosphate formation rate LYMPHOCYTE

Pharmacodynamic model of dopamine D1 receptor agonists in the treatment of breast cancer lung metastasis被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2020年第1期45-54,共10页Liang Yang Ye Yao Yaoyao Feng Wei Lu Tianyan Zhou; Natural Science Foundation of Beijing(Grant No.7192100).; Previous study has shown that dopamine D1 receptor(D1DR)agonists,fenoldopam(FEN)and l-stepholidine(l-SPD),have inhibitory effects on breast cancer lung metastasis.To quantitatively describe and predict the pharmacodyn...; 关键词：Pharmacodynamic model Dopamine D1 receptor agonist Cancer metastasis Breast cancer

Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists: 《Chinese Chemical Letters》2016年第1期159-162,共4页Jing Huang Bin Guo Wen-Jing Chu Xin Xie Yu-She Yang Xian-Li Zhou; supported by grants from the National Natural Science Foundation of China (No. 2140222); GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety pro...; 关键词：GPR40 ANTI-DIABETIC Agonist Phenylpropionic acid derivative

Risk of pancreatic adverse events associated with the use of glucagon-like peptide-1 receptor agonist and dipeptidyl peptidase-4 inhibitor drugs: A systematic review and metaanalysis of randomized trials被引量：1: 《World Journal of Meta-Analysis》2015年第6期254-283,共30页Hasan M Shihab Tokunbo Akande Kacie Armstrong Sonal Singh Yoon K Loke; AIM: To systematically assess risk of pancreatic adverse events with glucagon-like peptide-1(GLP-1) receptor agonist and dipeptidyl peptidase-4(DPP-4) inhibitor drugs.METHODS: We searched Pub Med, Embase, CINAHL, Coch...; 关键词：Diabetes MELLITUS PANCREATITIS Glucagon-like peptide-1 AGONISTS Dipeptidyl peptidase-4 inhibitors Meta-analysis

Recent advances in the role of toll-like receptors and TLR agonists in immunotherapy for human glioma被引量：7: 《Protein & Cell》2014年第12期899-911,共13页Shuanglin Deng Shan Zhu Yuan Qiao Yong-Jun Liu Wei Chen Gang Zhao Jingtao Chen; Gliomas are extremely aggressive brain tumors with a very poor prognosis. One of the more promising strat- egies for the treatment of human gliomas is targeted immunotherapy where antigens that are unique to the tumor...; 关键词：GLIOMA toll-like receptor AGONIST centralnervous system IMMUNOTHERAPY

Three-dimensional common-feature hypotheses for Toll-like receptor 7 agonists: 《Journal of Chinese Pharmaceutical Sciences》2013年第2期148-153,共6页齐世光于慧金宏威王占黎; supported by the National Natural Science Foundation of China(Grant No.20902068);Natural Science Foundation of Inner Mongolia Autonomous Region,China(Grant No.2011BS1201);Program for Young Talents of Science;Technology in Universities of Inner Mongolia Autonomous Region,China; Toll-like receptor 7 （TLR7）, the best known TLRs, has been demonstrated to be useful in fighting against infectious disease. In our study, three-dimensional （3D） pharmacophore models were constructed from a set of...; 关键词：Toll-like receptor 7 Agonist Common-feature hypothesis Molecular docking

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