WHOLE-CELL

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  • 学科=医药卫生—临床医学x
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Activation of zona incerta gamma-aminobutyric acid-ergic neurons alleviates depression-like and anxiety-like behaviors induced by chronic restraint stress
《World Journal of Psychiatry》2025年第2期209-221,共13页Si-Hai Chen Bo Lan Ying-Ying Zhang Guo-Hui Li Yu-Long Qian Ming-Xing Hu Yin-Lin Tian Wei-Dong Zang Jing Cao Guang-Hai Wang Yi-Gang Wang 
Supported by the Natural Science Foundation of Xiaogan,China,No.XGKJ2023010036.
BACKGROUND Depression is a prevalent affective disorder,but its pathophysiology remains unclear.Dysfunction in the gamma-aminobutyric acid(GABA)-ergic system may contribute to its onset.Recently,antidepressants(e.g.,b...
关键词：Zona incerta Gamma-aminobutyric acid-ergic DEPRESSION ANXIETY Animal behavior studies Whole-cell patchclamp 
Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function被引量：6
《Neural Regeneration Research》2022年第10期2253-2259,共7页Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang 
supported by the National Natural Science Foundation of China,Nos.81925031(to YT),81820108026(to YT),81972967(to WJL),81872549(to YL);the Youth Program of National Natural Science Foundation of China,No.81801229(to YTX);a grant from Guangdong Science and Technology Department of China,Nos.2020B1212060018(to WJL),2020B1212030004(to WJL);the Natural Science Foundation of Guangdong Province,No.2019A1515011754(to WJL);the Science and Technology Program of Guangzhou of China,No.202007030001(to YT);the Science and Technology Planning Project of Guangzhou of China,No.201704030033(to YL).
Radiation therapy is a standard treatment for head and neck tumors.However,patients often exhibit cognitive impairments following radiation therapy.Previous studies have revealed that hippocampal dysfunction,specifica...
关键词：GABA-mediated hyperfunction GluR intrinsic excitability long-term potentiation radiation-induced cognitive impairment spontaneous excitatory postsynaptic currents spontaneous inhibitory postsynaptic currents synaptic plasticity type I vesicular glutamate transporter vesicular GABA transporter whole-cell patch clamp recording 
MicroRNA is a potential target for therapies to improve the physiological function of skeletal muscle after trauma被引量：1
《Neural Regeneration Research》2022年第7期1617-1622,共6页Xin-Yi Gu Bo Jin Zhi-Dan Qi Xiao-Feng Yin 
supported by the National Natural Science Foundation of China,Nos.82072162,81971177;Beijing Municipal Natural Science Foundation of China,No.7192215(all to XFY)。
MicroRNAs can regulate the function of ion channels in many organs.Based on our previous study we propose that miR-142a-39,which is highly expressed in denervated skeletal muscle,might affect cell excitability through...
关键词：C2C12 DENERVATION ion channels MICRORNA miR-142a-3p muscle patch clamp potassium sodium whole-cell currents 
Expression and effect of sodium-potassium-chloride cotransporter on dorsal root ganglion neurons in a rat model of chronic constriction injury被引量：2
《Neural Regeneration Research》2020年第5期912-921,共10页Chao-Yang Tan Yan-Ping Wang Yuan-Yuan Han Bi-Han Lu Wei Ji Li-Cang Zhu Yang Wang Wen-Yan Shi Li-Ya Shan Liang Zhang Ke-Tao Ma Li Li Jun-Qiang Si 
supported by the National Natural Science Foundation of China,No.30160026(to JQS);the High Level Talent Research Project of Shihezi University of China,No.RCSX201705(to YW)
Sodium-potassium-chloride cotransporter 1 (NKCC1) and potassium-chloride cotransporter 2 (KCC2) are associated with the transmission of peripheral pain.We investigated whether the increase of NKCC1 and KCC2 is associa...
关键词：BUMETANIDE chronic constriction injury DORSAL ROOT ganglion DORSAL ROOT reflex hyperalgesia KCC2 nerve regeneration NEUROPATHIC pain NKCC1 primary afferent depolarization WHOLE-CELL patch clamp 
Perineuronal nets increase inhibitory GABAergic currents during the critical period in rats
《International Journal of Ophthalmology(English edition)》2013年第2期120-125,共6页Hui Liu Peng-Fen Gao Hai-Wei Xu Ming-Ming Liu Tao Yu Jun-Ping Yao Zheng-Qin Yin 
National Natural Sciences Foundation of China (No. 81070749)
AIM: To investigate inhibitory γ-aminobutyric acid (GABA) ergic postsynaptic currents (IPSCs) and postsynaptic currents (PSCs) in layer IV of the rat visual cortex during the critical period and when plasticity was e...
关键词：gamma-aminobutyric acid receptor PLASTICITY visual cortex development postsynaptic currents chondroitinase ABC chondroitin sulfate proteoglycans whole-cell patch recording 
Whole-cell recordings of voltage-gated Calcium,Potassium and Sodium currents in acutely isolated hippocampal pyramidal neurons
《Journal of Nanjing Medical University》2009年第2期122-126,共5页Shuyun Huang Qing Cai Weitian Liu Xiaoling Wang Tao Wang 
supported by Science Development Foundation of Tianjin Institute of Education(20070301)
Objective：To record Calcium, Potassium and Sodium currents in acutely isolated hippocampal pyramidal neurons. Methods：Hippocampal CA3 neurons were freshly isolated by 1 mg protease/3 ml SES and mechanical trituratio...
关键词：patch clamp HIPPOCAMPUS voltage-gated channels WHOLE-CELL 
Carvedilol Inhibits Na^+ Current in Rat Ventricular Myocytes
《South China Journal of Cardiology》2009年第2期85-89,共5页邓春玉 邝素娟 耿庆山 钱卫民 吴书林 单志新 林秋雄 杨敏 余细勇 林曙光 
supported by Guangdong Provincial Chinese Traditional Medicine Administration Foundation(2060033);Guangdong Provincial Medical Science and Technology Foundation (A2006002)
Objectives The effects of carvedilol on sodium current （INa） were investigated in isolated adult rat ventricular myocytes. Methods Single ventricular myocytes were enzymatically dissociated. INa was recorded by whol...
关键词：CARVEDILOL whole-cell patch clamp technique sodium current （INa） rat ventricular myocytes 
Identification of Peptides Inhibiting Adhesion of Monocytes to the Injured Vascular Endothelial Cells through Phage-displaying Screening被引量：3
《Acta Biochimica et Biophysica Sinica》2005年第4期227-233,共7页YuGUO JiaZHANG Ji-ChengWANG Feng-XiangYAN Bing-YangZHU Hong-LinHUANG Duan-FangLIAO 
This work was supported by the grants from the National Natural Science Foundation of China (No.30171084 and No.30470719);the National Basic Research Program of China (No.G2000056905)
Using oxidized low-density lipoprotein (LDL)-injured vascular endothelial cells (ECs) as target cells,peptides specifically binding to the injured ECs were screened from a phage-displaying peptide library by using the...
关键词：random peptide phage library vascular endothelial cell whole-cell screening cell adhesion caveolin-1 eNOS 
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