HYDROXYLASE

作品数：69被引量：120H指数：6
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相关机构：重庆医科大学江南大学四川省农业科学院首都医科大学更多>>
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Biocatalytic stereoselective synthesis of methyl mandelates by engineering a cytochrome P450 hydroxylase
《Green Synthesis and Catalysis》2024年第2期88-93,共6页Lingzhi Xie Yun Zhang Ruyue Zhang Haibo Cui Baodong Cui Wenyong Han Nanwei Wan Zhi Li Yongzheng Chen 
supported by the National Natural Science Foundation of China(Nos.21961048 and 32271537);Science and Technology Department of Zunyi(Nos.ZSKRPT-2020-5,ZSKH-2018-3 and ZSKRPT-2021-5).
Chiral methyl mandelates are useful synthons in organic transformation and pharmaceutical synthesis.Green synthesis of these valuable compounds by direct C–H activating oxidative hydroxylation has attracted keen inte...
关键词：Bio-hydroxylation Directed evolution Cytochrome P450 High-throughput screening Methyl mandelates 
A fungal CYP from Beauveria bassiana with promiscuous steroid hydroxylation capabilities
《Chinese Chemical Letters》2024年第5期218-222,共5页Yu Peng Yue Wang Tian-Jiao Chen Jing-Jing Chen Jin-Ling Yang Ting Gong Ping Zhu 
supported by the National Key Research and Development Program of China(Nos.2020YFA0908003 and 2018YFA0901900);CAMS Innovation Fund for Medical Sciences(No.CIFMS2021-I2M-1-029).
Hydroxylation of steroid core is critical to the synthesis of steroid drugs.Direct sp^(3) C-H hydroxylation is challenging through chemical catalysis,alternatively,fungal biotransformation offers a possible solution t...
关键词：Fungal CYPs Steroid hydroxylase Beauveria bassiana Promiscuous biocatalyst Molecular dynamics 
Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta‑hydroxylase deficiency
《World Journal of Pediatrics》2024年第4期422-433,共12页Wen‑Li Lu Xiao‑Yu Ma Jiao Zhang Jun‑Qi Wang Ting‑Ting Zhang Lei Ye Yuan Xiao Zhi‑Ya Dong Wei Wang Shou‑Yue Sun Chuan‑Yin Li Rong‑Gui Hu Guang Ning Li‑Dan Zhang 
Background The clinical manifestations of nonclassical 11beta-hydroxylase deficiency are very similar to those of nonclassical 21-hydroxylase deficiency.For this study,we investigated the relationship between the clin...
关键词：11β-hydroxylase deficiency CYP11B1 Enzymatic activity Phenotype-genotype correlation Threedimensional protein simulations 
Flavanone and flavonoid hydroxylase genes regulate fiber color formation in naturally colored cotton
《The Crop Journal》2023年第3期766-773,共8页Hongli Zheng Bailin Duan Bo Yuan Zhengbin Chen Dongliang Yu Liping Ke Wenlong Zhou Haifeng Liu Yuqiang Sun 
supported by the Natural Science Foundation of Zhejiang Province(LZ21C130004);the National Natural Science Foundation of China(U1903204);he Fundamental Research Funds of Shaoxing Keqiao Research Institute of Zhejiang Sci-Tech University(KYY2021004S)。
Using naturally colored cotton(NCC)can eliminate dyeing,printing and industrial processing,and reduce sewage discharge and energy consumption.Proanthocyanidins(PAs),the primary coloration components in brown fibers,ar...
关键词：Naturally colored cotton Brown cotton fiber Fiber color Anthocyanidin Flavanone/flavanoid hydroxylase 
Characterization of the P450 Monooxygenase LobP1 as C-32 Hydroxylase in Lobophorin Biosynthesis
《Chinese Journal of Chemistry》2023年第12期1478-1484,共7页Bin Tan Qingbo Zhang Ji Xiao Chengshan Yuan Yuchan Chen Siqiang Chen Weimin Zhang Yiguang Zhu Changsheng Zhang 
supported in part by the National Natural Science Foundation of China(22193072 and 32100045);the Key Science and Technology Project of Hainan Province(ZDKJ202018);MOST(2018YFA0901903);K.C.WongEducationnFoundation(GJTD-2020-12);the Guangdong Provincial Special Fund for Marine Economic Development Project(GDNRC[2021]48);the Science and Technology Planning Project of Guangzhou(202102020471);Rising Star Foundation of the South China Sea Institute of Oceanology(NHXX2018SW0201)。
Lobophorins(LOBs)belong to a large family of spirotetronate antibiotics with antibacterial and antitumor activities.In this study,we demonstrated the function of LobP1,a P450 monooxygenase encoded in the LOB biosynthe...
关键词：Lobophorins BIOSYNTHESIS Post modifications P450 monooxygenase HYDROXYLATION Enzymes Biological activity Structure elucidation 
BmCH25H,a vertebrate interferon-stimulated gene(ISG)homolog,inhibits BmNPV infection dependent on its hydroxylase activity in Bombyx mori被引量：3
《Insect Science》2023年第2期321-337,共17页Hongyun Wu Junming Xia Shigang Fei Yeyuan Wang Mengmeng Zhang Yiyao Guo Xian Li Luc Swevers Jingchen Sun Min Feng 
supported by the Natural Science Foundation of Guangdong Basic and Applied Basic Research Fund(2022A1515012657);Guangzhou Science and Technology Plan Project(202002030218);National Natural Science Foundation of China(31872426);South China Agricultural University high-level talent launch project;Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry(No.2018-143);Innovation and Entrepreneurship Training Program for College Students in Guangdong Province(S202110564098).
Cholesterol-25-hydroxylase(CH25H)has been identified as an interferon-stimulated gene(ISG)in mammals that exerts its antiviral effects by catalyzing the conversion of cholesterol to 25-hydroxycholesterol(25HC).However...
关键词：Bombyx mori nucleopolyhedrovirus Bombyx mori Cholesterol 25-hydroxylase Interferon-stimulated genes Signal transducer and activator of transcription 
Molecular diagnosis of phenylketonuria in 157 Chinese families and the results of prenatal diagnosis in these families被引量：1
《Chinese Medical Journal》2021年第13期1626-1628,共3页Yang Xiao Qiang Gu Hai-Rong Wu Song-Tao Wang Pei Pei Xue-Fei Zheng Hong Pan Yi-Nan Ma 
To the Editor:Phenylketonuria(PKU)is an autosomal recessive genetic disease caused by pathogenic variants in the phenylalanine hydroxylase(PAH)gene encoding phenylalanine hydroxylase,a key enzyme in the metabo-lism of...
关键词：DIAGNOSIS HYDROXYLASE maintained 
Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana被引量：2
《Synthetic and Systems Biotechnology》2020年第3期236-243,共8页Fengwei Li Li Ma Xingwang Zhang Jingfei Chen Feifei Qi Yinyue Huang Zepeng Qu Lishan Yao Wei Zhang Eung-Soo Kim Shengying Li 
This work was supported by the National Key Research and Development Program of China(2019YFA0905100 to S.L.);the National Natural Science Foundation of China(31800664 to F.L.,31872729 to S.L.and 31600045 to L.M.);General Support from China Postdoctoral Science Foundation(Grant No.2017M622293 to F.L.);Shandong Provincial Natural Science Foundation,China(ZR2019ZD22 to S.L.and ZR2016CQ05 to L.M.);the Applied Basic Research Programs of Science and Technology of Qingdao(17-1-1-60-jch to L.M.);National Research Foundation of Korea(No.NRF-2017R1A2A2A05069859 to E.-S.K.).
The cytochrome P450 enzyme CYP-sb21 from the rare actinomycete Sebekia benihana is capable of hydroxylating the immunosuppressive drug molecule cyclosporine A(CsA)primarily at the 4th N-methyl leucine(MeLeu4),giving r...
关键词：Cytochrome P450 monooxygenase Crystal structure Cyclosporine A Regioselectivity Hair growth stimulator 
Construction of an efficient genomic editing system with CRISPR/Cas9 in the vector mosquito Aedes albopictus被引量：3
《Insect Science》2019年第6期1045-1054,共10页Tong Liu Wen-Qiang Yang Yu-Gu Xie Pei-Wen Liu Li-Hua Xie Feng Lin Chen-Ying Li Jin-Bao Gu Kun Wu Gui-Yun Yan Xiao-Guang Chen 
the National Natural Science Foundation of China (81420108024,81528013);National Institute of Allergy and Infectious Diseases Grants of USA(AI136850);the National Key R&D Program of China(2016YFC1200500);the Natural Science Foundation of Guangdong Province(2014A030312016,2016A020251001);the Guangzhou Synergy Innovation Key Program for Health(201508020263,201605030010).
Aedes (Stegomyia) albopictus, also known as the Asian tiger mosquito, is a mosquito which originated in Asia. In recent years, it has become increasingly rampant throughout the world. This mosquito can transmit severa...
关键词：AEDES ALBOPICTUS CRISPR/Cas9 dopachrome conversion enzyme (yellow) gene editing KYNURENINE HYDROXYLASE (kh) 
Ginsenoside Rb1 protects dopaminergic neurons from inflammatory injury induced by intranigral lipopolysaccharide injection被引量：15
《Neural Regeneration Research》2019年第10期1814-1822,共9页Da-Wei Li Fa-Zhan Zhou Xian-Chang Sun Shu-Chen Li Jin-Bin Yang Huan-Huan Sun Ai-Hua Wang 
supported by the Medical and Health Technology Development Plan of Shandong Province of China,No.2011HD009(to AHW);the Chinese Medicine Science and Technology Development Plan Project of Shandong Province of China,No.2017-163(to AHW);the Natural Science Foundation of Shandong Province of China,No.ZR2016HP23(to AHW);the Science and Technology Development Plan Project of Taian City of China,No.2017NS0151(to XCS)
Accumulating studies suggest that neuroinflammation characterized by microglial overactivation plays a pivotal role in the pathogenesis of Parkinson’s disease.As such,inhibition of microglial overactivation might be ...
关键词：nerve REGENERATION neurodegeneration Parkinson's disease GINSENOSIDE Rb1 neuroinflammation LIPOPOLYSACCHARIDE DOPAMINERGIC neuron microglia nuclear factor kappa B dopamine TYROSINE HYDROXYLASE substantia nigra neural REGENERATION 
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