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作品数:917被引量:3082H指数:22
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相关领域:医药卫生更多>>
相关作者:朱依敏何荣环唐朝枢王伟忠袁文俊更多>>
相关机构:浙江大学中南大学浙江大学医学院附属妇产科医院中山大学附属第一医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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CD146,a therapeutic target involved in cell plasticity
《Science China(Life Sciences)》2024年第8期1563-1578,共16页Zhenzhen Wu Yuzhe Zang Chuyi Li Zhiheng He Jingyu Liu Zhaoqi Du Xinran Ma Lin Jing Hongxia Duan Jing Feng Xiyun Yan 
supported in part by the Beijing Natural Science Foundation of China(L232077,7242092,7222117);the National Natural Science Foundation of China(82000812);the China Postdoctoral Science Foundation(2023M733682).
Since its identification as a marker for advanced melanoma in the 1980s,CD146 has been found to have multiple functions in both physiological and pathological processes,including embryonic development,tissue repair an...
关键词:CD146 cell plasticity therapeutic target 
Ferroptosis:a critical mechanism of N^(6)-methyladenosine modification involved in carcinogenesis and tumor progression
《Science China(Life Sciences)》2024年第6期1119-1132,共14页Qingqing Wei Changning Xue Mengna Li Jianxia Wei Lemei Zheng Shipeng Chen Yumei Duan Hongyu Deng Faqing Tang Wei Xiong Ming Zhou 
supported by the National Natural Science Foundation of China(82172592);the Free Exploration Program of Central South University(2021zzts0934);the program of Introducing Talents of Discipline to Universities(111-2-12)。
Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid peroxidation.It occurs when multiple redoxactive enzymes are ectopically expressed or show abnormal function.Hence,the preci...
关键词:ferroptosis m6A modification RNA methylation m^(6)A regulator tumor progression 
PINK1 is involved in determining the cellular autophagic hierarchy
《Science China(Life Sciences)》2024年第5期1087-1088,共2页Zhuchen Zhou Zhong Chen Yanrong Zheng 
supported by the National Natural Science Foundation of China (82273903)。
The protein PINK1 plays a crucial role in the regulation of the cellular autophagic hierarchy.Autophagy,a highly conserved biological process,serves as a mechanism for the degradation of intracellular components by ly...
关键词:PINK1 DETERMINING HIERARCHY 
Techniques for increasing the yield of stem cell-derived exosomes:what factors may be involved?被引量:1
《Science China(Life Sciences)》2022年第7期1325-1341,共17页Zi-Yuan Feng Qing-Yi Zhang Jie Tan Hui-Qi Xie 
sponsored by the National Natural Science Foundation of China(31771065);Sichuan Science and Technology Program(2019JDRC0020);the“1.3.5 Program for Disciplines of Excellence,”West China Hospital,Sichuan University(ZYJC18002)。
Exosomes are nano-scale extracellular vesicles secreted by cells and constitute an important part in the cell-cell communication.The main contents of the exosomes include proteins,micro RNAs,and lipids.The mechanism a...
关键词:EXOSOME stem cell YIELD therapy 
Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells被引量:2
《Science China(Life Sciences)》2021年第7期1087-1096,共10页Yang Zhoui Leqing Cao Huidong Guo Yan Hong Ming Wang Ke Wang Xiaojun Huang Yingjun Chang 
partly supported by grants from the National Key Research and Development Program of China(2017YFA0104500);National Natural Science Foundation of China(81670168);the Key Program of National Natural Science Foundation of China(81230013)。
Acute graft-versus-host disease(a GVHD)is caused by allo-activated donor T cells infiltrating target organs.As a regulator of immune function,granulocyte colony-stimulating factor(G-CSF)has been demonstrated to reliev...
关键词:granulocyte colony-stimulating factor graft-versus-host disease mouse model Th2 polarization 
A GATA-type transcription factor AcAREB for nitrogen metabolism is involved in regulation of cephalosporin biosynthesis in Acremonium chrysogenum被引量:8
《Science China(Life Sciences)》2017年第9期958-967,共10页Feifei Guan Yuanyuan Pan Jinyang Li Gang Liu 
supported by the National Natural Science Foundation of China(31670091 and 31470177)
In filamentous fungi,nitrogen metabolism is repressed by GATA-type zinc finger transcription factors.Nitrogen metabolite repression has been found to affect antibiotic production,but the mechanism is still poorly unde...
关键词:AcareB Acremonium chrysogenum cephalosporin biosynthesis GATA-type transcription factor REGULATION 
A single mutation in the PBC loop of VP2 is involved in the in vitro replication of infectious bursal disease virus被引量:3
《Science China(Life Sciences)》2016年第7期717-723,共7页Xiaole Qi Xiang Gao Zhen Lu Lizhou Zhang Yongqiang Wang Li Gao Yulong Gao Kai Li Honglei Gao Changjun Liu Hongyu Cui Yanping Zhanga Xiaomei Wang 
supported by the National Natural Science Foundation of China (31430087);the Scientific and Technological Research Project of Harbin (2014AB3AN058);the Special Fund for Scientific and Technological Innovative Talents of Harbin (2014RFQYJ129);the Modern Agro-industry Technology Research System of China (nycytx-42-G3-01)
To test whether amino acid mutations in the PBC and PHI loops of VP2 are involved in the replication and virulence of infectious bursal disease virus(IBDV), a pair of viruses, namely the moderately virulent IBDV(rG x-...
关键词:infectious bursal disease virus (IBDV) VP2 PUC REPLICATION 
Transcriptome analysis reveals long noncoding RNAs involved in fiber development in cotton (Gossypium arboreum)被引量:11
《Science China(Life Sciences)》2016年第2期164-171,共8页Changsong Zou Qiaolian Wang Cairui Lu Wencui Yang Youping Zhang Hailiang Cheng Xiaoxu Feng Mtawa Andrew Prosper Guoli Song 
the National Natural Science Foundation of China (31301369, 31271768, 31401425)
Long noncoding RNAs (lncRNAs) play important roles in various biological regulatory processes in yeast, mammals, and plants. However, no systematic identification of lncRNAs has been reported in Gossypium arboreum. ...
关键词:long noncoding RNAs strand specific RNA sequencing fiber TRANSCRIPTOME expression 
New players in ABA signaling: identification of PUB12/13 involved in degradation of ABA co-receptor ABI1被引量:3
《Science China(Life Sciences)》2015年第11期1173-1174,共2页MA Xuan MO Bei Xin CAO Xiao Feng 
Abscisic acid (ABA) was originally identified in the early 1960s, and was thought to be involved in fruit and leaf ab- scission. Over the past 50 years, ABA was intensely studied and has become one of the vital plan...
关键词:早期鉴定 ABA 信号 蛋白磷酸酶 球员 降解 受体 植物激素 
miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction被引量:9
《Science China(Life Sciences)》2013年第5期431-439,共9页ZHAO Na YU HaiYi YU HaiTao SUN Min ZHANG YouYi XU Ming GAO Wei 
supported by the National Natural Science Foundation of China (81100164,31271212,81070196,81030001);the Research Fund for the Doctoral Program of Higher Education (20100001110101,20110001120015);the Program for New Century Excellent Talents in University,the Beijing Talents Foundation
Although microRNAs (miRNAs) have been intensively studied in cardiac fibrosis, their roles in drug-mediated anti-fibrotic therapy are still unknown. Previously, Pioglitazone attenuated cardiac fibrosis and increased...
关键词:PIOGLITAZONE miR-711 cardiac fibrosis 
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