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The relation of synaptic biomarkers with Aβ,tau,glial activation,and neurodegeneration in Alzheimer’s disease
《Translational Neurodegeneration》2024年第1期736-740,共5页Yi-Ting Wang Nicholas J.Ashton Stijn Servaes Johanna Nilsson Marcel S.Woo Tharick A.Pascoal Cécile Tissot Nesrine Rahmouni Joseph Therriault Firoza Lussier Mira Chamoun Serge Gauthier Ann Brinkmalm Henrik Zetterberg Kaj Blennow Pedro Rosa-Neto Andréa L.Benedet 
supported by the Canadian Institutes of Health Research(CIHR)[MOP-11–51-31,RFN 152985,159815,162303];Canadian Consortium of Neurodegeneration and Aging(CCNA;MOP-11–51-31-team 1);Weston Brain Institute,the Alzheimer’s Association[NIRG-12–92090,NIRP-12–259245];Brain Canada Foundation(CFI Project 34874,33397);the Fonds de Recherche du Québec–Santé(FRQS;Chercheur Boursier,2020-VICO-279314)。
Main text Synaptic degeneration is a prominent feature of vari-ous neurodegenerative diseases and represents an early pathogenic event in Alzheimer’s disease(AD)[1,2].Multiple synapse-specific proteins involved in di...
关键词：GAP43 ALZHEIMER TAU AΒ 
CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation
《Translational Neurodegeneration》2024年第1期93-113,共21页Yan-Yan Xue Zhe-Sheng Zhang Rong-Rong Lin Hui-Fen Huang Ke-Qing Zhu Dian-Fu Chen Zhi-Ying Wu Qing-Qing Tao 
supported by grants from the National Natural Science Foundation of China(81970998);the Science Innovation 2030-Brain Science and Brain-Inspired Intelligence Technology Major Projects(Nos.2021ZD0201103 and 2021ZD0201803);the Key R&D Program of Zhejiang(2024SSYS0018).
Background Alzheimer’s disease(AD)is the most common form of neurodegenerative disorder,which is characterized by a decline in cognitive abilities.Genome-wide association and clinicopathological studies have demonstr...
关键词：Alzheimer’s disease CD2AP P38 MAPK Synaptic injury Tau 
p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease
《Translational Neurodegeneration》2023年第1期890-907,共18页Jia-Bing Li Xiao-Yu Hu Mu-Wen Chen Cai-Hong Xiong Na Zhao Yan-Hui Ge Hao Wang Xiao-Ling Gao Nan-Jie Xu Lan-Xue Zhao Zhi-Hua Yu Hong-Zhuan Chen Yu Qiu 
supported by the National Natural Science Foundation of China(81802840,81473217);Shanghai Natural Science Foundation(20ZR1430100);Shanghai High Level Local University Construction Project(PT21002).
Background Ribosomal protein S6 kinase 1(S6K1)is a serine-threonine kinase that has two main isoforms:p70S6K(70-kDa isoform)and p85S6K(85-kDa isoform).p70S6K,with its upstream mammalian target of rapamycin(mTOR),has b...
关键词：Alzheimer’s disease COGNITION GluA1 subunit of AMPA receptors Ribosomal S6 protein kinase 1 85 kDa isoform 
Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson’s disease
《Translational Neurodegeneration》2023年第1期90-110,共21页Wenying Xu Jie Wang Xin-Ni Li Jingxue Liang Lu Song Yi Wu Zhenguo Liu Bomin Sun Wei-Guang Li 
supported by grants from the STI2030-Major Projects(2022ZD0208605);the National Natural Science Foundation of China(32071023,82271274,82171242);the Science and Technology Commission of Shanghai Municipality(22XD1420700);the Shanghai Municipal Health Commission(2022XD046);innovative research team of high-level local universities in Shanghai(SHSMU-ZDCX20211901).
Deep brain stimulation(DBS)is a well-established and effective treatment for patients with advanced Parkinson’s disease(PD),yet its underlying mechanisms remain enigmatic.Optogenetics,primarily conducted in animal mo...
关键词：Parkinson’s disease Deep brain stimulation OPTOGENETICS Opto-DBS Synaptic adaptation Orthodromic effects Antidromic effects Long-lasting therapeutic effects 
N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer’s disease被引量：1
《Translational Neurodegeneration》2023年第1期111-129,共19页Xiong Wang Jiazhao Xie Lu Tan Yanjun Lu Na Shen Jiaoyuan Li Hui Hu Huijun Li Xiaoguang Li Liming Cheng 
supported by the National Natural Science Foundation of China(82372337,81500925 to Xiong Wang,81801062 to Xiaoguang Li);Tongji Hospital(HUST)Foundation for Excellent Young Scientist(2020YQ01-11 to Xiong Wang);the Natural Science Foundation of Hubei Province(2022CFB150 to Huijun Li).
Background Synaptic degeneration occurs in the early stage of Alzheimer’s disease(AD)before devastating symptoms,strongly correlated with cognitive decline.Circular RNAs(circRNAs)are abundantly enriched in neural tis...
关键词：Alzheimer’s disease circRNA Synaptic dysfunction GluN2B UBIQUITINATION 
Correction:Starburst amacrine cells,involved in visual motion perception,lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
《Translational Neurodegeneration》2023年第1期574-574,共1页Xavier Sánchez-Sáez† Isabel Ortuño-Lizarán† Carla Sánchez-Castillo Pedro Lax Nicolás Cuenca 
Correction:Translational Neurodegeneration(2023)12:17(2023)https://doi.org/10.1186/s40035-023-00348-y Following publication of the original article[1],the authors reported an error in the article title.Following publi...
关键词：DEGENERATE motion LOOSE 
Starburst amacrine cells,involved in visual motion perception,lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients被引量：1
《Translational Neurodegeneration》2023年第1期638-653,共16页Xavier Sánchez-Sáez Isabel Ortuño-Lizarán Carla Sánchez-Castillo Pedro Lax Nicolás Cuenca 
support from the Ministerio de Ciencia e Innovación(FEDER-PID 2019-106230RB-I00);Ministerio de Universidades(FPU16/04114),Instituto Carlos III(RETICS-FEDER RD16/0008/0016);FARPE-FUNDALUCE,Generalitat Valenciana-FEDER(IDIFEDER/2017/064,PROMETEO/2021/024,APOSTD/2020/245);Es Retina Asturias(2019/00286/001);Michael J Fox Foundation for Parkinson’s Research.
Background The main clinical symptoms characteristic of Parkinson’s disease(PD)are bradykinesia,tremor,and other motor deficits.However,non-motor symptoms,such as visual disturbances,can be identified at early stages...
关键词：Parkinson’s disease Retinal neurodegeneration Human retina ChAT amacrine cells Dopaminergic amacrine cells 
Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance,neuroinflammation and Alzheimer’s disease
《Translational Neurodegeneration》2022年第1期931-948,共18页Alessandro Dario Confettura Eleonora Cuboni Mohamed Rafeet Ammar Shaobo Jia Guilherme M.Gomes PingAn Yuanxiang Rajeev Raman Tingting Li Katarzyna M.Grochowska Robert Ahrends Anna Karpova Alexander Dityatev Michael R.Kreutz 
the Deutsche Forschungsgemeinschaft(DFG)(Kr 1879/9-1/FOR 2419,Kr1879/5-1/6-1/10-1;CRC1436 A02 Project-ID 425899996;Research Training Group 2413 SynAGE,TP4),BMBF‘Energi’FKZ:01GQ1421B,The EU Joint Programme-Neurodegenerative Disease Research(JPND)project STAD(01ED1613)and Leibniz Foundation SAW‘ISAS2’,’SynMetAge’,’Neurotranslation’and’SynErca’to MRK.;CRC1436 A02 Project-ID 425899996 to AK;CRC1436 A05 Project-ID 425899996,Research Training Group 2413 SynAGE TP5 and BMBF‘Energi’FKZ:01GQ1421A to AD.G.M.G.was supported by the Alexander-von-Humboldt Foundation/CAPES post-doctoral research fellowship(99999.001756/2014-01).
Background:The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Al...
关键词：Metabolic syndrome Alzheimer’s disease NEDDYLATION Cullins MLN-4924 Insulin IRS1 Amyloid-β TNFα 
NMDAR-dependent somatic potentiation of synaptic inputs is correlated withβamyloid-mediated neuronal hyperactivity
《Translational Neurodegeneration》2021年第3期432-446,共15页Yifei Bao Xin Yang Yi Fu Zhengyan Li Ru Gong Wei Lu 
This work was supported by grants to W.L.from the National Natural Science Foundation of China(31730107,31970959,31671056).
Background:βAmyloid(Aβ)-mediated neuronal hyperactivity,a key feature of the early stage of Alzheimer’s disease(AD),is recently proposed to be initiated by the suppression of glutamate reuptake.Nevertheless,the und...
关键词：NMDA receptor HYPERACTIVITY Somatic modifcation Alzheimer’s disease 
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