Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TM...
the financial supports from National Natural Science Foundation of China (Nos.81971678 and 81671756);the Innovation Fund for Postgraduate Students of Central South University (No.2019zzts1019)。
Intracellular pH is a key parameter related to various biological and pathological processes.In this study,a ratiometric pH fluorescent sensor ABTT was developed harnessing the amino-type excited-state intramolecular ...
This work was supported by“National Key Research and Development Program of China”(Project No.2018YFC1603400);Science and Technology Program of Hebei Province(Project No.19225503D).
The aim of this work was to develop an automated on-line solid phase extraction(SPE)with liquid chromatography-tandem mass spectrometry method for the detection of fifteen sulfonamides in pork and fish samples.Samples...
supported by the National Natural Science Foundation of China(31770616 and 21601087);the Natural Science Foundation for Colleges and Universities in Jiangsu Province(17KJA220002);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015C221)。
The title compounds(7a^7g)were synthesized from dehydroabietic acid and characterized by spectroscopic methods including HR-MS,1H-and 13C-NMR.The crystal structure of compound 7g determined by single-crystal X-ray dif...
This project was supported by the National Natural Science Foundation of China(No.21876143);Science and Technology Program of Henan Province(No.172102210088);Nanhu Scholars Program for Young Scholars of XYNU。
OH addition reactions of cationic,neutral and anionic forms of three sulfonamides(sulfamethoxazole,sulfadiazine and sulfapyridine)in aqueous solution were theoretically studied using density functional theory(DFT)meth...
Supported by Guangxi Natural Science Foundation(No.2016GXNSFAA380292);National Natural Science Foundation of China(No.21661011)
Co-crystal is a very potential kind of drug solid forms, and has a far-reaching influence on designing and preparing drugs. A new 1:1:1 co-crystal compound consisting of 4-amino-3,5-dichloro-benzenesulfonamide, 1,10...
supported by the National Nature Science Foundation of China (No. 51406109)
In this paper, we propose a novelmethod based on the plate theory to simultaneously predict retention times and peak shapes under gradient elutions and different flow rates by reversed-phase high-performance liquid ch...
Supported by the National Natural Science Foundation of China(Nos. 81373259, 81573286).
A new and convenient procedure was developed for the preparation of sulfonamides and sulfonic esters using N-fluorobenzenesulfonimide(NFSI) as a novel phenylsulfonyl group transfer reagent. In this protocol, a broad...
This work was supported by National Natural Science Foundation of China (Nos. 20931006, 21072070, 21272088 and 21571110), the Program for Academic Leader in Wuhan Municipality (No. 201271130441), the Natural Science Foundation of Ningbo City (No. 2016A610051) and financially supported by research funds of NBU (No. ZX2015000586).
The detection of cations has attracted considerable interest because of their importance in various physiological processes. In this study, compound 1 bearing sulfonamidc and morpholine functionalities was synthesized...
The vibrational spectral analysis was carried out by using FT-Raman and FT-IR spectroscopy in the range 4 000~400and 4 000~400cm-1 respectively,for N-[4-[1-hydroxy-2-[(1-methyl ethyl)amino]ethyl]phenyl]methane sulfona...