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DRUG-INDUCED: 作品数：120被引量：422H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：魏群吴和珍骆静尹江华郭礼和更多>>; 相关机构：北京师范大学中国科学院上海生命科学研究院浙江大学首都医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划更多>>

Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes: 《Science China(Life Sciences)》2024年第2期301-319,共19页Xiaoli Tang Hong Liu Rongjia Rao Yafei Huang Mengqi Dong Miaomiao Xu Shanshan Feng Xun Shi Li Wang Zengwu Wang Bingying Zhou; supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-1-I2M-006,2023-I2M-1-003,2022-I2M-2-001,2021-1-I2M-019);the National Natural Science Foundation of China(82070287,82088101 and 82025004);the National Key Research and Development Program of China(2022YFA1104500)。; Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’lives.However,mitochondrial toxicity testing is not inco...; 关键词：remdesivir mitochondrial toxicity CARDIOTOXICITY human primary cardiomyocytes high-throughput screening

A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals被引量：4: 《Animal Models and Experimental Medicine》2022年第5期436-444,共9页Abbasali Abbasnezhad Fatemeh Salami Reza Mohebbati; Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s)of action of toxic agents as well as drugs or sub-stances under consideration.The use of toxins in laborato...; 关键词：ANIMAL drug toxicity drug-induced abnormality liver dysfunction renal injury

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts被引量：2: 《Acta Pharmaceutica Sinica B》2022年第10期3905-3923,共19页Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto Jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan; supported by the National University Heart Centre Singapore (NUHCS) Cardiovascular Research Institute (CVRI)Core Fund [Grant NUHSRO/2019/082/Core];SCEPTRE CG Seed Grant [Grant NMRC/CG/M008/2017, Singapore];Singapore Ministry of Education Tier 1 Academic Research Funding [Grant R-148-000-193-112];the National University of Singapore, Department of Pharmacy, Final Year Project Funding [Grant C148-000-003-001] provided to Eric Chun Yong Chan;from Japan Society for the Promotion of Science (JSPS) KAKENHI [grant number 20K16136] provided to Ryuichi Kambayashi; Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adver...; 关键词：Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation DRONEDARONE

PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway被引量：2: 《Acta Pharmaceutica Sinica B》2022年第5期2391-2405,共15页Peihua Liu Ling Jiang Weimin Kong Qiushi Xie Ping Li Xiaonan Liu Jiayi Zhang Ming Liu Zhongjian Wang Liang Zhu Hanyu Yang Ying Zhou Jianjun Zou Xiaodong Liu Li Liu; supported by the National Natural Science Foundation of China (Nos.81673505,81872930,and 82073922);the “Double First-Class” university project (No.CPU2018GY22,China);“333” Project of Jiangsu Province (No.BRA2020287,China)。; Drug-induced hyperglycemia/diabetes is a global issue. Some drugs induce hyperglycemia by activating the pregnane X receptor(PXR), but the mechanism is unclear. Here, we report that PXR activation induces hyperglycemi...; 关键词：Pregnane X receptor Hepatocyte nuclear factor4-alpha Glucose transporter 2 Hepatic glucose uptake Diabetes Drug-induced hyperglycemia

Drug-induced stuttering:A comprehensive literature review被引量：1: 《World Journal of Psychiatry》2022年第2期236-263,共28页Naemeh Nikvarz Salehe Sabouri; Drug-induced stuttering(DIS)is a type of neurogenic stuttering(NS).Although DIS has not been reported as frequently as other cases of NS in the literature,it is not a negligible adverse drug reaction(ADR)which can sig...; 关键词：DRUG Dysfluency Dysphemia PSYCHOTROPICS Speech Stammering

DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy被引量：2: 《Acta Pharmaceutica Sinica B》2015年第4期330-336,共7页Yue Sheng Bo Sun Xin Xie Na Li Deli Dong; supported by the National Natural Science Foundation of China (No. 81373406); Our previous work found that DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl]quinoline) was a novel autophagy inhibitor. Here, we aimed to investigate the effects of DMH1 on chemotherapeutic drug-induced ...; 关键词：AUTOPHAGY TAMOXIFEN 5-Fluorouracil Cancer cells

缺乏依从性对合理用药影响之分析: 《药物与人》2015年第2期210-210,共1页陈卫红; 目的：提高病患依从性,促进合理用药的可行性,倡导安全用药人人有责.方法：了解并分析病患缺乏依从性的产生原因及其后果的危害性.结果：病患不依从性普遍存在是临床合理用药的主要障碍之一.结论：病患良好的依从性是保证合理用药的一...; 关键词：药物(Drug) 合理用药(Rationaldruguse) 依从性(Compliance) 药源性疾病(Drug-induceddiseases DID)

Mechanisms of drug-induced proarrhythmia in clinical practice被引量：2: 《World Journal of Cardiology》2013年第6期175-185,共11页Arkadia Konstantopoulou Spyros Tsikrikas Dimitrios Asvestas Panagiotis Korantzopoulos Konstantinos P Letsas; Drug-induced proarrhythmia represents a great challenge for those involved in the development of novel pharmaceuticals and in the regulatory bodies for drug approval as well as for the prescribing clinicians.Our under...; 关键词：Drugs SUDDEN cardiac death Long QT SYNDROME Short QT SYNDROME BRUGADA SYNDROME

Antiepileptic drug-induced multidrug resistance P-glycoprotein overexpression in astrocytes cultured from rat brains被引量：21: 《Chinese Medical Journal》2004年第11期1682-1686,共5页吕洋晏勇王学峰; Background Intractable epilepsy may be due to multidrug resistance induced by conventional antiepileptic drugs. The phenomenon is sometimes associated with an overexpression of multidrug resistance gene 1 (MDR 1). T...; 关键词：antiepileptic drugs · P-glycoprotein · multidru g resistance gene · astrocytes

Effects of cyclophosphamide on protein expression of rat embryo at end of pre-gastrulation stage in vivo: 《Acta Pharmacologica Sinica》2000年第6期76-78,共3页洪缨楼宜嘉; Project supported by the National Natural Science Foundation of China, № 39470836,;by the Natural Science Foundation of Zhejiang Province, № 398458; AIM: To seek a sensitive time point for pre-gastrulation embryos exposed to developmental toxic agents, and to establish a molecular biomarker to evaluate the mechanism of cyclophosphamide-induced embryonic abnormalit...; 关键词：fetal development drug-induced abnonnalities BLASTOCYST mutagens gene expression regulation

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