supported by grants from STI 2030-Major Projects(2021ZD0203203,2021ZD02044400);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32000000);the National Natural Science Foundation of China(31871066,31922028,and 31900721);the Shanghai Municipal Science and Technology Major Project(2018 SHZDZX05).
Dear Editor,Instinctual male mating actions serve the fundamental purpose of bringing the two gametes together in sexually reproducing species[1,2].Upon encountering a conspecific female,a male mouse investigates the ...
supported by grants from the STI2030-Major Projects(2021ZD0202700);the National Natural Science Foundation of China(82090032,31830033,T2394535,32200947);the Key-Area Research and Development Program of Guangdong Province(2018B030334001,2018B030340001);the Science and Technology Program of Guangzhou(202007030013);the China Postdoctoral Science Foundation(2022M721491).
The transition of affective states manifests affective regulation,wherein individuals adaptively adjust their emotional states to cope with changes in the external environment,reflecting their sensitivity and adaptabi...
supported by the STI2030-Major Projects(2021ZD0202800).
Behaviors can be shaped and modulated by the dopamine system,which can be remodeled in adolescents due to environmental factors,including pharmacologic exposure,stress,and rewarding experiences,leading to various adol...
supported by the Natural Science Foundation of Zhejiang Province(LY23H090001).
The peripheral and central nervous systems have numerous examples of two or more neuroactive products co-existing in the same neuron[1],which can simultaneously be released as both fast-acting neurotransmitters and sl...
Opioid use disorder(OUD)has become a considerable global public health challenge;however,potential medications for the management of OUD that are effective,safe,and nonaddictive are not available.Accumulating preclini...
The brain circuits underlying sleep-wake regulation are not fully understood,although significant progress has been made in the past few decades[1-3].Different sleep-wake states arecontrolledbydistinct neural circuits.
supported by the National Natural Science Foundation of China(81790640,82070993,31571072,32070989,31872766,31571075,81430007,and 81470661);the Ministry of Science and Technology of China(2011CB504602 and 2015AA020512);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);ZJLab,Shanghai Center for Brain Science and Brain-Inspired Technology,Sanming Project of Medicine in Shenzhen(SZSM202011015);Anhui Medical University Research Foundation(2020xkj003),China.
Reduced levels of retinal dopamine,a key regulator of eye development,are associated with experimental myopia in various species,but are not seen in the myopic eyes of C57BL/6 mice,which are deficient in melatonin,a n...
This insight was,supported by,the National NaturalScienceFoundationofChina(32171233,32000704,81974203,81901308,31670843,21790390,and 21790394);the Natural Science Foundation of Sichuan Province,China(2020YJ0337 and 2020YJ0378);the Natural ScienceFoundation of Shaanxi Province of China(2020JQ-029 and 2019JC-07);the Key Research and Development Program of Shaanxi Province,China(2017SF-113);the Science and Technology Innovation Projects of China(20-163-00-TS-009-035-01);China Postdoctoral Science Foundation(2018M640972);the Innovation Capability Support Programof Shaanxi Province,China(2021TD-37).
Parkinson's disease(PD)is a common neurodegenerative disease among the elderly,characterized by the specific loss of dopaminergic(DAergic)neurons in the substantia nigra pars compacta(SNpc)and defects in dopamine(DA)r...
supported by the National Natural Science Foundation of China(81801366 and 82001453)and the National Key R&D Program of China(2018YFC2001901).
Dopaminergic neurons in the ventral tegmental area(VTA)play an important role in cognition,emergence from anesthesia,reward,and aversion,and their projection to the cortex is a crucial part of the"bottom-up"ascending ...
the National Nature Science Foundation of China(81771521);Key Research and Development Plan of Liaoning Science and Technology Department(2018225051);Guangdong Provincial Key R&D Program(2018B030337001);the National Key Research and Development Program of China(2016YFC1306600).
Parkinson’s disease(PD)is the second most common neurodegenerative disease,which manifests with both motor and non-motor symptoms.Circadian rhythm dysregulation,as one of the most challenging non-motor features of PD...