Objective: PulmonaryMycobacterium tuberculosis infection can trigger cellular and humoral innate immune responses, which may cause death of the pathogen and or host cells/tissue. We aimed to determine the cytotoxic re...
supported by a grant from State Key Laboratory of Proteomics of China,No.SKLP-K201401(to SJL);the National Key Project of Basic Research of China,No.2009CB918301(to SJL);the National Natural Science Foundation of China,Nos.30430310,30140001,30370460(to SJL)
Microglia, as the resident immune cells in the central nervous system, play important roles in regulating neuronal processes, such as neural excitability, synaptic activity, and apoptotic cell clearance. Growth factor...
Migration of polymorphonuclear leukocytes from bloodstream to the site of inflammation is an important event required for surveillance of foreign antigens.This trafficking of leukocytes from bloodstream to the tissue ...
supported by a Cornell start-up fund and NIH grants (R01NS099125 and R21OD023824) awarded to C.H.
Dendrites and axons are delicate neuronal membrane extensions that undergo degeneration after physical injuries. In neurodegenerative diseases, they often degenerate prior to neuronal death. Understanding the mechanis...
Supported by grants from CONICET(Argentina,EM,PIP-CONICET 112-201101-00247,http://www.conicet.gov.ar);ANPCyT(Argentina,EM,PICT 2012-174,PICT 2017-499;http://www.agencia.mincyt.gob.ar);NIH-CONICET(Argentina and USA,EM and Stephen Noctor,F65096).
Until recently,microglia were mainly known as the resident phagocytes of the brain,i.e.the‘immunological warriors’of the brain.However,extensive knowledge is being accumulated about the functions of microglia beyond...
Objective To investigate expression differences of neutrophil and mononuclear phagocyte related gene mRNAs among acute myocardial infarction (AMI), stable angina (SA) and control groups, and then discuss their exp...
Mycobacterium tuberculosis ( M. tuberculosis) is a pathogen associated with the deaths of millions of people worldwide annually. Although tuberculosis is a treatable disease, the emergence and increasing prevalence...
It is generally accepted that the most of the chemical energy in the form of ATP used during phagocytosis is derived from the glycolytic pathway and oxidative phosphorylation. Loik (1979) found that phagocytes contain...