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作品数：8被引量：18H指数：3
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Targeting TRPM2- and TRPM4-extrasynaptic N-methyl-D-aspartate receptor coupling in ischemic stroke被引量：1
《Neural Regeneration Research》2023年第11期2383-2384,共2页Pengyu Zong Cindy X.Li Jianlin Feng Lixia Yue 
National Institute of Health (R01-HL143750);American Heart Association (19TPA34890022) to LY。
Ischemic stroke represents a heavy burden on public health.Currently,recanalization is the only effective therapy for ischemic stroke in a small population of eligible patients.However,there is no effective adjunct me...
关键词：ASPARTATE ISCHEMIC MEDICATION 
Modulating balance of synaptic and extrasynaptic NMDA receptors as strategy for Alzheimer disease drug discovery
《中国药理学与毒理学杂志》2019年第6期404-404,共1页ZHOU Wen-xia 
The unbalance between synaptic(Glu N2 A, mediating the protective pathway) and extrasynaptic NMDA receptors(NMDARs)(Glu N2 B, mediating the excitotoxic pathway) has been found in Alzheimer disease(AD), indicating rest...
关键词：Alzheimer disease GLU N2A GLU N2B IFENPRODIL D-CYCLOSERINE drug discovery 
S1A-5 Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects Against Amyloid-Beta-Induced Neurotoxicity
《神经药理学报》2018年第4期25-26,共2页ZHOU Wen-xia HUANG Yan SHEN Wei SU Jie CHENG Bin LI Dong LIU Gang ZHANG Yong-xiang 
The unbalance between synaptic(GluN2A,mediating the protective pathway)and extrasynaptic NMDA receptors(NMDARs)(GluN2B,mediating the excitotoxic pathway)has been found in Alzheimer’s disease(AD),indicating restoring ...
关键词：GluN2B-selective ANTAGONIST NMDRs similar to D-SERINE 
The adjustment of γ-aminobutyric acid_A tonic subunits in Huntington＇s disease：from transcription to translation to synaptic levels into the neostriatum
《Neural Regeneration Research》2018年第4期584-590,共7页Abraham Rosas-Arellano Argel Estrada-Mondragón Carola A.Mantellero Carlos Tejeda-Guzmán Maite A.Castro 
the programs for the postdoctoral fellowships-Chilean CONICYT-FONDECYT#3140218,Mexican CONACYT#164978 and DID-UACh S-2015-81;Sistema Nacional de Investigadores#58512 to Abraham Rosas-Arellano;supported by USACH PhD fellowship;supported with a PhD fellowship from CONACYT(#299627);FONDECYT grants 1151206 and 1110571 to Maite A.Castro
γ-Aminobutyric acid（GABA）,plays a key role in all stages of life,also is considered the main inhibitory neurotransmitter.GABA activates two kind of membrane receptors known as GABAA and GABAB,the first one is respo...
关键词：GABAA extrasynaptic and perisynaptic y-aminobutyric acidA receptors STRIATUM R6/1  R6/2 HdhQ92  HdhQ111  HdhQ150  N171-82Q and YAC128 HD transgenics mice models CHOREA mutanthuntingtin inhibitory neurotransmission D1 medium sized spiny neurons D2 medium sized spiny neurons 
Activation of extrasynaptic GABA_A receptors inhibits cyclothiazideinduced epileptiform activity in hippocampal CA1 neurons被引量：3
《Neuroscience Bulletin》2014年第5期866-876,共11页Li Wan Xu Liu Zheng Wu Wanting Ren Shuzhen Kong Raya Abou Dargham Longzhen Cheng Yun Wang 
supported by grants from the National Natural Science Foundation of China(31129003,81100815,81171224, 81401082,and 81301108);the Science and Technology Commission of Shanghai Municipality,China(13DJ1400302, 13ZR1406500,and 11ZR1401700)
Extrasynaptic GABAA receptors （GABAARs）-mediated tonic inhibition is reported to involve in the patho- genesis of epilepsy. In this study, we used cyclo- thiazide （CTZ）-induced in vitro brain slice seizure model t...
关键词：GABAARS tonic inhibition EPILEPSY population spike CYCLOTHIAZIDE hippocampal CA1 neurons 
Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β被引量：8
《Neuroscience Bulletin》2013年第6期752-760,共9页Zhi-Cong Wang Jie Zhao Shao Li 
supported by the National Natural Science Foundation of China(81371223 and 81371437);the Research Fund for the Doctoral Program of Higher Education of China(20122105110010);the Science and Technology Project of Liaoning Province,China(2011226006)
The toxicity of amyloid-beta（Aβ） is strongly associated with Alzheimer’s disease（AD）,which has a high incidence in the elderly worldwide.Recent evidence showed that alteration in the activity of N-methyl-D-aspar...
关键词：amyloid-β synaptic NMDA receptor extrasynaptic NMDA receptor NEUROTOXICITY 
Volume Transmission and Its Different Forms in the Central Nervous System被引量：6
《Chinese Journal of Integrative Medicine》2013年第5期323-329,共7页Kjell Fuxe Dasiel O.Borroto-Escuela Wilber Romero-Fernandez 张维波 Luigi F.Agnati 
Supported by grants from the Swedish Research Council (04X-715);Torsten and Ragnar Sderberg Foundation, Hjrnfonden and Marianne and Marcus Wallenberg Foundation to KF,by a grants from the Swedish Royal Academy of Sciences and Karolinska Institutet Forskningsstiftelser 2012 to DOB-E
Volume transmission （VT） is a widespread mode of intercellular communication that occurs in the extracellular fluid （ECF） and in the cerebrospinal fluid （CSF） of the brain with VI signals moving from source to t...
关键词：extrasynaptic volume transmission long distance volume transmission Roamer type of volume transmission Chinese medicine MERIDIAN 
Changes in synaptic and extrasynaptic N-methyl-D-aspartate receptor-mediated currents at early-stage epileptogenesis in adult mice
《Neural Regeneration Research》2011年第2期118-124,共7页Juegang Ju Sheng-tian Li 
Shanghai Pujiang Program,No. 06PJ14053;the National Natural Science Foundation of China,No. 30600177;the Scientific Research Founda-tion for the Returned Over-seas Chinese Scholars,State Education Ministry;Doctoral Fund of Ministry of Education of China,No. 20070248083;Shanghai Leading Aca-demic Discipline Project,No. B205
Previous reports have shown that N-methyl-D-aspartate （NMDA） receptors are extensively involved in epilepsy genesis and recurrence. Recent studies have shown that synaptic and extrasynaptic NMDA receptors play diffe...
关键词：N-methyl-D-aspartate receptor excitatory postsynaptic current epilepsy EPILEPTOGENESIS hippocampus 
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