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PRION: 作品数：175被引量：154H指数：5; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：朱钦士赵德明周筠梅练富林柯莎更多>>; 相关机构：中国农业大学中国科学院南加州大学厦门大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国科学院知识创新工程重要方向项目更多>>

Establishment of a Special Platform for the Research of Prion and the Diagnosis of Human Prion Disease —China’s Studies: 《China CDC weekly》2022年第33期729-734,共6页Kang Xiao Qi Shi Cao Chen Wei Zhou Chen Gao Liping Gao Jun Han Jichun Wang Xiaoping Dong; Supported by SKLID Development Grant(2021SKLID506,2019SKLID501,2019SKLID603,2021SKLID101);National Natural Science Foundation of China(81572048).; The studies of prions and prion disease usually need many special platforms and techniques that differ from those for classical microbes.Search of new biomarkers and establishment of new methods for the diagnosis of h...; 关键词：HUMAN DIAGNOSIS PRION

Extensive Disturbances of Intracellular Components and Dysfunctions of Biological Pathways in the Brain Tissues During Prion Infection—China’s Studies: 《China CDC weekly》2022年第33期741-747,共7页Qi Shi Cao Chen Kang Xiao Wei Zhou Chen Gao Liping Gao Jun Han Jichun Wang Xiaoping Dong; Supported by National Key R&D Program of China(2020YFE0205700);SKLID Development Grant(2021SKLID503,2021SKLID504,2019SKLID401);National Natural Science Foundation of China(81772197,81630062,81401670).; The study describes some of the major findings of changes in intracellular components and biological pathways in the brain during prion infection and hypothesizes some important physiological and pathological approach...; 关键词：alterations HOMEOSTASIS summarized

朊样蛋白Doppel的研究进展: 《中国预防兽医学报》2022年第6期676-681,共6页王川俞海山杨宇泽魏亚琴张钊万学瑞贾晓蕊吴润; 国家自然科学基金(32060822、31500067);甘肃省科技计划项目重点研发计划(18YF1NA077);甘肃农业大学动物医学院学科建设基金(GSAU-XKJS-2018-074)。; 传染性海绵状脑病(Transmissible spongiform encephalopathies,TSEs)是由朊蛋白(Prion protein,PrP)引起的一种致命的神经退行性疾病,最早于18世纪中期在欧洲地区羊群中发现羊瘙痒病,目前已在人和多种哺乳动物发现了传染性海绵状脑病...; 关键词：传染性海绵状脑病朊蛋白痒病神经退行性疾病 PRION PrP 错误折叠

Distinct effects of Cu^2＋-binding on oligomerization of human and rabbit prion proteins被引量：2: 《Acta Biochimica et Biophysica Sinica》2015年第10期842-850,共9页Kejiang Lin Ziyao Yu Yuanhui Yu Xinli Liao Pei Huang Chenyun Guo Donghai Lin; This work was supported by the grants from the National Natural Science Foundation of China （Nos. 31170717, 31470034, and 31270777）.; The cellular prion protein （PrP^C） is a kind of cell-surface Cu^2＋-binding glycoprotein. The oligomerization of PrP^C is highly related to transmissible spongiform encephalopathies （TSEs）. Cu^2＋ plays a vital ro...; 关键词：Cu^2＋ prion oligomerization AFFINITY conformational stability TSE-resistance

The structure of prion： is it enough for interpreting the diverse phenotypes of prion diseases？被引量：1: 《Acta Biochimica et Biophysica Sinica》2013年第6期429-434,共6页Chan Tian Xiaoping Dong; Funding This work was supported by the grants from the National Natural Science Foundation of China （81101302, 31270185）, China Mega-Project for Infectious Disease （2011ZX10004-101, 2012ZX10004215）, and SKLID Development Grant （2012SKLID102）.; Prion diseases, or transmissible spongiform encephalop- athies, are neurodegenerative diseases, which affect human and many species of animals with 100% fatality rate. The most accepted etiology for prion disease is ...; 关键词：PRP PRPC prion disease PrP structure

Prion protein oligomer and its neurotoxicity: 《Acta Biochimica et Biophysica Sinica》2013年第6期442-451,共10页Pei Huang Fulin Lian Yi Wen Chenyun Guo Donghai Lin; Funding This work was supported by the grants from the National Natural Science Foundation of China （Nos. 31170717, 91129713, and 30900233）.; The prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders. According to the ＇protein only＇ hypothesis, the key molecular event in the pathogenesis of priori d...; 关键词：PRION OLIGOMER NEUROTOXICITY transmissiblespongiform encephalopathies

Recent progress in prion and prion-like protein aggregation被引量：1: 《Acta Biochimica et Biophysica Sinica》2013年第6期520-526,共7页Chuan-Wei Yi Wen-Chang Xu Jie Chen Yi Liang; Funding This work was supported by the grants from the National Key Basic Research Foundation of China （Grants 2013CB910702 and 2012CB911003）, National Natural Science Foundation of China （Grants 31170744 and 30970599）, and Fundamental Research Funds for the Central Universities of China （Grant 1104006）.; Prion diseases and prion-like protein misfolding diseases involve the accumulation of abnormally aggregated forms of the normal host proteins, such as prion protein and Tau protein. These proteins are special because ...; 关键词：prion protein prion-like protein proteinmisfolding physiological environment macromolecularcrowding

Prion-like behavior of MAVS in RIG-I signaling被引量：3: 《Cell Research》2011年第12期1643-1645,共3页Eva Marie Y Moresco Diantha La Vine Bruce Beutler; Viral infection triggers the innate antiviral response in part through acti- vation of RIG-I, a cytoplasmic sensor of 5＇-triphosphorylated and uncapped single- or double-stranded RNA, which are not found among endoge...; 关键词：朊病毒双链RNA 信令行为信号蛋白转录激活病毒感染先天免疫

Expression of Recombinant Protein Bovine Prion pCIp264 in COS-7 Cells and Its Detection: 《Journal of Life Sciences》2010年第5期30-36,共7页Yaozhong Ding Yongsbeng Liu Wenqian Liu Yanping Ma Meng Wang Shenghai Yang Jie Zhang; Acknowledgment This work was supported by grants from the National Natural Science Foundation （30671563, 30700597） and Key Project of Science and Technology of Gansu Province （0801NKDA034） and by gifts from the Development Planning Project of Science and Technology of Lanzhou （07-2-12, 2008- l- 167）.; Bovine spongiform encephalopathy （BSE） is thought to be caused by prions initially derived from sheep scrapie, and epidemiological studies suggest that new viriant form of CJD manifest in Great Britain may be caused...; 关键词：Bovine prion protein （boprp） COS-7 cells indirect immunofluorescence assay （IFA）

PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site被引量：4: 《Cell Research》2009年第9期1062-1078,共17页Cathryn L Haigh Victoria A Lewis Laura J Vella Colin L Masters Andrew F Hill Victoria A Lawson Steven J Collins; The copper-binding, membrane-anchored, cellular prion protein （PrP~） has two constitutive cleavage sites producing distinct N- and C-terminal fragments （N1/C1 and N2/C2）. Using RK13 cells expressing either human P...; 关键词：PRION COPPER endoproteolytic cleavage signal transduction lipid raft

PRION