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Comparative metabolomics reveal histamine biodegradation mechanism by salt stressed Bacillus subtilis JZXJ-7
《Food Science and Human Wellness》2025年第3期925-940,共16页Rundong Wang Yijia Deng Yuhao Zhang Xuepeng Li Ravi Gooneratne Jianrong Li 
supported by the National Key R&D Program of China(2019YFD0901702);National Natural Science Foundation of China(32201929,32202134);2025 Guangdong Basic and Applied Basic Research Foundation of Natural Science Foundation Project(2025A1515011748);High-level Talent Project of Lingnan Normal University(ZL2415);China Postdoctoral Science Foundation(2022M712625);2021 and 2022 Chongqing Postdoctoral Special Funding Project。
Bacillus subtilis JZXJ-7 isolated from shrimp paste can significantly degrade histamine under salt stress but the mechanism is unclear.This study aims to evaluate the effect of 170 and 340 mmol/L Na Cl on B.subtilis J...
关键词：Bacillus subtilis JZXJ-7 HISTAMINE Salt stress Antioxidant enzymes Metabolomics 
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids
《World Journal of Gastrointestinal Surgery》2025年第4期333-346,共14页Min-Hui Ke Shu-Yan Huang Wei-Gan Lin Zhen-Guo Xu Xia-Xia Zheng Xian-Bao Liu You-Min Cheng Zuan-Fang Li 
Supported by the National Natural Science Foundation of China,No.81774118;the Foreign Cooperation Project of Science and Technology Department of Fujian Province,No.2023I0021;the Medical Innovation Project of Fujian Province,No.2024CXB013.
BACKGROUND Hemorrhoids,a prevalent chronic condition globally,significantly impact patients'quality of life.While various surgical interventions,such as external stripping and internal ligation,procedure for prolapse ...
关键词：Internal hemorrhoids Xiaozhiling injection FIBROBLAST Marker gene Single-cell sequencing Spatial transcriptome sequencing 
16S amplicon sequencing and untargeted metabolomics reveal changes in rumen microorganisms and metabolic pathways involved in the reduction of methane by cordycepin被引量：1
《Journal of Integrative Agriculture》2025年第4期1310-1326,共17页Haokai Ma Dengke Liu Rui Liu Yang Li Modinat Tolani Lambo Baisheng Dai Weizheng Shen Yongli Qu Yonggen Zhang 
financially supported by the National Key Research and Development Program of China(2023YFD2000701);the Natural Science Foundation of Heilongjiang Province,China(YQ2023C011);the Key Research and Development Program of Heilongjiang Province,China(Grant no.2022ZX01A24);the Key Laboratory of Low-carbon Green Agriculture in Northeastern China,Ministry of Agriculture and Rural Affairs of China(LCGANE14)。
As a major contributor to methane production in agriculture,there is a need for a suitable methane inhibitor to reduce ruminant methane emissions and minimize the impact on the climate.This work aimed to explore the i...
关键词：CORDYCEPIN in vitro rumen fermentation rumen microbiome METABOLOME methane production 
Multi-time point transcriptomics and metabolomics reveal key transcription and metabolic features of hepatic ischemia-reperfusion injury in mice
《Genes & Diseases》2025年第2期288-303,共16页Qi Li Xiaoyan Qin Liangxu Wang Dingheng Hu Rui Liao Huarong Yu Zhongjun Wu Yanyao Liu 
funded by the National Natural Science Foundation of China (No.82300745 to Yanyao Liu);China Postdoctoral Science Foundation (No.2023M730442 to Yanyao Liu);Chongqing Postdoctoral Science Foundation of China (No.CSTB2023NSCQ-BHX1003 to Yanyao Liu);Postdoctoral Cultivation Project of the First Affiliated Hospital of Chongqing Medical University (No.CYYY-BSHPYXM-202301 to Yanyao Liu);Chongqing Postdoctoral Innovation Talents Support Program (Chongqing,China) (No.2309013437264551 to Yanyao Liu)。
Hepatic ischemia-reperfusion injury is an unavoidable surgical complication of liver transplantation and the leading cause of poor graft function and increased mortality post-transplantation.Multiple mechanisms have b...
关键词：INFLAMMATION Liver ischemia-reperfusion injury Metabolic remodeling Metabolomics TRANSCRIPTOMICS 
Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis
《World Journal of Gastroenterology》2025年第16期30-48,共19页Ying Zhu Shi-Yu Geng Yao Chen Qing-Jing Ru Yi Zheng Na Jiang Fei-Ye Zhu Yong-Sheng Zhang 
Supported by the Zhejiang Provincial Natural Science Foundation,No.LZ22H270001.
BACKGROUND Hepatic fibrosis(HF)represents a pivotal stage in the progression and potential reversal of cirrhosis,underscoring the importance of early identification and therapeutic intervention to modulate disease tra...
关键词：Chronic hepatitis B virus infection Hepatic fibrosis Liver stiffness Fecal microbiomes Serum intestinal mucosal barrier 
Reveal short range interactions between u/d quarks in the NN,D_(03),and D_(30)systems
《Science China(Physics,Mechanics & Astronomy)》2025年第3期102-111,共10页Qi-Fang Lü Yu-Bing Dong Peng-Nian Shen Zong-Ye Zhang 
supported by the National Natural Science Foundation of China(Grant No.12375142);the Natural Science Foundation of Hunan Province(Grant No.2023JJ40421);the Key Project of Hunan Provincial Education Department(Grant No.21A0039);the Youth Talent Support Program of Hunan Normal University(Grant No.2024QNTJ14);the National Key Research and Development Program of China(Grant No.2020YFA0406300)。
The dynamic mechanism of short range interactions between u/d quarks remains an open and challenging problem.In order to reveal this quark dynamics,we perform a systematic analysis of N N,D_(03),and D_(30)systems in t...
关键词：short range interactions DIBARYONS constituent quark models 
Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets
《Neural Regeneration Research》2025年第3期725-739,共15页Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler 
funded by NIH-NIA R01AG061708 (to PHO);Patrick Grange Memorial Foundation (to PHO);A Long Swim (to PHO);CureSPG4 Foundation (to PHO)。
Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understan...
关键词：ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST SPASTIN 
Target enrichment data reveal rapid divergence with reticulate evolution of Maianthemum(Asparagaceae:Convallarioideae)in the Himalayan-Hengduan Mountains and eastern Asia
《Journal of Systematics and Evolution》2025年第1期85-98,共14页Yan-Yang Xie Ze-Long Nie Meng-Hua Zhang Ming-Yang Song Jun Wen Ying Meng 
supported by grants from Natural Sciences Foundation of China(32160052,31760055);Natural Sciences Foundation of Hunan Province(2019JJ40232 and 2019JJ40233).
Understanding plant diversity and the phylogenetic divergences in the Northern Hemisphere is essential for in-depth evolutionary studies and conservation efforts.Maianthemum is an ideal example to explore plant divers...
关键词：ASPARAGACEAE Himalayan-Hengduan Mountain Maianthemum PHYLOGENOMICS reticulate evolution 
A genome-wide association study and transcriptome analysis reveal the genetic basis for the Southern corn rust resistance in maize
《Journal of Integrative Agriculture》2025年第2期453-466,共14页Yang Wang Chunhua Mu Xiangdong Li Canxing Duan Jianjun Wang Xin Lu Wangshu Li Zhennan Xu Shufeng Sun Ao Zhang Zhiqiang Zhou Shenghui Wen Zhuanfang Hao Jienan Han Jianzhou Qu Wanli Du Fenghai Li Jianfeng Weng 
supported by the National Key R&D Program of China(2022YFD1201802);the Shandong Key R&D Program,China(2022CXGC010607);the Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202109);the Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP2017-ICS);the Subproject of the Major Project of Science and Technology in Shanxi Province,China(202201140601025-1-02)。
Southern corn rust(SCR)is an airborne fungal disease caused by Puccinia polysora Underw.(P.polysora)that adversely impacts maize quality and yields worldwide.Screening for new elite SCR-resistant maize loci or genes h...
关键词：MAIZE southern corn rust genome-wide association study TRANSCRIPTOME 
Integrated metabolomics and proteomics analyses reveal the molecular mechanism underlying the yellow leaf phenotype of Camellia sinensis被引量：1
《Horticultural Plant Journal》2025年第1期417-430,共14页Nana Li Weizhong He Yufan Ye Mingming He Taimei Di Xinyuan Hao Changqing Ding Yajun Yang Lu Wang Xinchao Wang 
supported by the Project for Collaborative Promotion of Agricultural Major Technology of Zhejiang Province(Grant No.2022XTTGCY01-02);the National Natural Science Foundation of China(Grant Nos.31700615,32172633);the China Agriculture Research System of MOF and MARA(Grant No.CARS19-01A);the Special Project of Zhejiang Province(Grant No.2020R52036)。
The tea plant cultivar‘Zhonghuang 2'(ZH2)possesses albino-induced yellow leaves that contain low levels of catechins but high contents of amino acids.However,the molecular mechanism underlying the yellow leaf phenoty...
关键词：Tea plant Chlorophyll-deficient mutant Chlorophyll biosynthesis Photosynthetic protein Antioxidant capacity Photooxidative stress 
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