supported by the National Natural Science foundation of China(Nos.22225104,92356302,22071077,21975102).
Indole derivatives,especially bisindolylesters,have attracted intense attention due to their important applications in medicinal chemistry and organic synthesis.Here we develop a Lewis acid-catalyzed efficient and reg...
the Independent Research Foundation of Key Laboratory of Green and Precise Synthetic Chemistry and Applications in Huaibei Normal University,Ministry of Education;the University Top Talents Academic Funding Project of Anhui Province(gxbjzD2021097);the Natural Science Foundation of Educational Committee from Anhui Province and Huaibei Normal University(KJ2020A0045,KJ2020A1199,KJ2020B01,2023ZK078,2023ZK079);the University Synergy Innovation Program of Anhui Province(GXXT-2020-078)for financial support of this work.
Herein,a DMAP-catalyzed[4+2]annulation ofα-substituted allenoates with arylazosulfones is reported,which affords facile access to tetrahydropyridazine derivative in synthetically useful yields.This reaction features ...
the funding support of the National Natural Science Foundation of China(No.21871240);the Strategic Priority Research Program of the CAS(No.XDPB14);the Fundamental Research Funds for the Central Universities(No.WK2060190082)。
Herein,copper-catalyzed 1,4-protosilylation and 1,4-protoborylation of enynic orthoesters have been developed.The enynic orthoesters as precursors of unstable enynic esters were applied to produce the functionalized 2...
The authors are grateful to NSFC(Nos.21971066 and 21772042)for financial support.Special thanks to prof;Junliang Zhang(Fudan University)for his kind suggestion on this[3 t 2]cycloaddition reaction.
A highly efficient and mild method for[3 t 2]cycloaddition ofβ-sulfonyl-α,β-unsaturated ketones with terminal allenoates was well-explored and developed.The reactions were successfully performed by applying multifu...
the National Natural Science Foundation of China(No.21702189);Key Scientific and Technological Project of Henan Province(No.202102310004);Zhengzhou University(No.JC21253007)of China for financial support.
Lewis base-catalyzed annulations of allenoates have been one of the most powerful synthetic strategies for the synthesis of various valuable cycles,especially in the preparation of biologically active natural products...
Yixin Lu thanks the Singapore National Research Foundation,Prime Minister’s Office for the NRF Investigatorship Award(R-143-000-A15-281);Financial supports from the National University of Singapore(R-143-000-695-114 and C-141-000-092-001);the National Natural Science Foundation of China(21672158)are also gratefully acknowledged.
An enantioselective umpolung γ-addition reaction of 3’-indolyl-3-oxindoles to allenoates catalyzed by amino acid-derived bifunctional phosphine catalysts has been developed. A wide range of chiral mixed 3,3’-bisind...
supported by the National Natural Science Foundation of China(Nos. 21372256, 21572264)
The double [3 + 2] cycloaddition of allenoates with nitrile oxides is presented. The reaction worked well under mild reaction conditions to give the spirobidihydroisoxazole in moderate to excellent yields with excelle...
Financial support from the Fundamental Research Funds for the Central Universities (No. KYZ201749) and the National Natural Science Foundation of China (Nos. 21272119, J1103306) are gratefully acknowledged.
A phosphine-catalyzed [4+2] annulation of a-substituted allenoate with exocyclic alkene moiety of oxindoles or indan-1,3-diones has been developed. Thus, under the catalysis of PPh3 (20 mol%), a series of spirooxin...
Supported by the National Natural Science Foundation of China(No. 21372096).
Phosphine-catalyzed [4+2] annulations of 2-(acetoxymethyl)buta-2,3-dienoates with α-aminonitriles have been developed, in which a-aminonitriles serve as C, N-bisnucleophilic reaction partners and 2-(acetoxymethyl...
In contrast with the reported phosphine- and DABCO-catalyzed [3 + 2] and [2 +2] annulation of allenoates with trifluoromethylketone, the [2+2+2] annulation of allenoates and two molecules of trifluoromethylketone ...