PHOSPHODIESTERASE

作品数：80被引量：149H指数：6
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  • 期刊=中国药理学与毒理学杂志x
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Regulation by phosphodiesterase of anxiety-and depressive-like behavior induced by alcohol withdrawal in mice
《中国药理学与毒理学杂志》2021年第9期667-668,共2页LIU Xiao-qian WANG Dong ZHENG Wen-qing ZHANG Fang-fang ZHANG Han-ting 
OBJECTIVE Alcohol dependence is not only the most common public health prob⁃lem worldwide,but also the cause of many alco⁃hol-related diseases,such as anxiety and depres⁃sion.However,the mechanism of these comor⁃bidit...
关键词：PHOSPHODIESTERASES alcohol with⁃drawal behavior 
Comparison of phosphodiesterase 7 expres⁃sion in brain striatum of C57BL/6J and DBA/2J mice and association with ethanol drinking behavior
《中国药理学与毒理学杂志》2021年第9期668-668,共1页ZHANG Fang-fang DU Xian ZHOU Yan-meng ZHENG Wen-qing LIU Xiao-qian ZHANG Han-ting 
National Natural Science Foundation of China(81773717);National Natural Science Foundation of China(81801510);Academic Promotion Program of Shandong First Medical University(2019QL011);and Science and Technology Development Plan Project in Tai′an City(2017NS0237).
OBJECTIVE Cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling has been shown to regulate alcohol consumption.The phosphodiesterase 7(PDE7)enzyme is one of the PDE families responsible for controlling i...
关键词：PHOSPHODIESTERASE ethanol drinking behavior 
FCPR16 induces AMPK-dependent autophagy and provides neuroprotection in SH-SY5Y cells and neurons exposed to MPP^+-induced oxidative damage
《中国药理学与毒理学杂志》2019年第6期460-461,共2页ZHONG Jia-hong XIE Jin-feng XIAO Jiao ZHOU Zhong-zhen WANG Hai-tao XU Jiang-ping 
National Natural Science Foundation of China(81773698);Guangzhou Science and Technology Department(2015B020211007; and 201604020112)
OBJECTIVE The cause of Parkinson disease (PD) is generally not clear, but it is considered to be related to excessive oxidative damage. Therefore, the identification of therapeutic targets and compounds with antioxida...
关键词：PHOSPHODIESTERASE 4 FCPR16 OXIDATIVE stress MITOCHONDRIAL membrane potential PARKINSON disease 
Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP^+ -induced decline of mitochondrial membrane potential and oxidative stress被引量：10
《中国药理学与毒理学杂志》2018年第9期699-700,共2页ZHONG Jia-hong XIE Jin-feng XIAO Jiao LI Dan ZHOU Zhong-zhen WANG Hai-tao XU Jiang-ping 
NationalNatural Science Foundation of China (81773698);Funding from Guangzhou Science and Technology Department (2015B020211007,201604020112).
Parkinson disease(PD) is a chronic neurodegenerative disorder caused by progressive dopaminergic neuronal death in the substantia nigra pars compacta within the midbrain.There still is no cure,effective treatments for...
关键词：PHOSPHODIESTERASE 4 FCPR16 oxidative stress MITOCHONDRIAL membrane potential PARKINSON disease 
Icariside Ⅱ, a PDE5 inhibitor, attenuates cerebral ischemia/reperfusion injury through activating BDNF/TrkB/CREB signaling pathway
《中国药理学与毒理学杂志》2018年第9期671-671,共1页XU Fan LYU Chun DENG Yan LIU Yuan-gui GONG Qi-hai SHI Jing-shan GAO Jian-mei 
National Natural Science Foundation of China(81560585);Program for Excellent Young Talentsof Zunyi Medical University(15zy-002);Scienceand Technology Innovation Talent Team of GuizhouProvince(20154023);the hundred”Level of High—level Innovative Talents in Guizhou Province(QKHRCPT 20165684):Education Department of Guizhou Province of China[GNYL(2017)006,YLXKJS—YS一06];Program for Changjiang Scholars and lnnovative Research Team in University,China(IRT-17R113).
OBJECTIVE To explore the effects and mechanism of icariside Ⅱ(ICS Ⅱ),a pharmacologically active compound derived from herbal Epimedii with previous study-proved phosphodiesterase 5(PDE5) inhibitors,was investigated ...
关键词：icarisideⅡ oxygen-glucose DEPRIVATION REPERFUSION PHOSPHODIESTERASE 5 apoptosis 
Phosphodiesterase 1:a unique therapeutic target with multiple potential indications
《中国药理学与毒理学杂志》2017年第5期452-453,共2页Larry WENNOGLE 
Cyclic-nucleotide phosphodiesterase 1(PDE1) is a unique enzyme family hydrolyzing both cyclic guanosine monophosphate(cGMP) and cyclic adenosine monophosphate(cAMP) intra-cellular signaling molecules. A unique aspect ...
关键词：cyclic-nucleotide phosphodiesterase 1 calmodulin-activation COGNITION DEGENERATIVE THERAPIES 
Phosphodiesterases:novel targets for treatment of alcoholism
《中国药理学与毒理学杂志》2017年第5期454-455,共2页LIU Xin WEN Rui-ting GONG Mei-fang XU Ying Nicolas GRAHAME XU Jiang-ping LIANG Jian-hui Marco CONTI 张汉霆 
OBJECTIVE Alcoholism is one of the most damaging psychiatric disorders and causes serious social and health problems in the world. However,there are no ideal treatments for this disease in clinic.Phosphodiesterases(PD...
关键词：PHOSPHODIESTERASE alcohol drinking ALCOHOLISM ANXIETY DEPRESSION RODENTS 
用磷酸化蛋白组学分析鉴别磷酸二酯酶功能（英文）
《中国药理学与毒理学杂志》2017年第5期445-446,共2页Joseph BEAVO 
We now know that 11 different families of cyclic nucleotide phosphodiesterases(PDEs) are expressed in mammalian species. Most of these families contain multiple gene products and most of the genes utilize alternative ...
关键词：PHOSPHODIESTERASE PHOSPHOPROTEOME CAMP SIGNALING 
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