Treatment of cancer with chemotherapy often faces drug resistance issues, which can stop after a period of remission. This resistance is due to several mechanisms;among them, the most important is the one in relation ...
Supported by the Natural Science Foundation for Middle-Aged;Young Scientist of Gansu Province(No.YS031-A21-015)
Objective: To investigate the effect of total flavonoids of Hedysarum polybotry on the proliferation, cell cycle, and expressions of p21Ras and proliferating cell nuclear antigen (PCNA) gene in erythroleukemia cell...
the National Natural Science Foundation of China (Grant Nos. 30270355 & 10572007)
After injecting VP16, MEL cells and MEL-TF19 cells into the body of mice, with those injected with the same dose of saline as the control group, we observed the mice for their blood pictures, histological changes of t...
Clk/STY is a LAMMER protein kinase capable to phosphorylate serine/arginine-rich (SR) proteins that modulate pre-mRNA splicing. Clk/STY alternative splicing generates transcripts encoding a full-length kinase and a tr...
This work supported by the National Natural Sciences Foundation of China(39670364);This work was originally published in Acta Academiae Medicinae Sinicae(2001;23: 32-35)in Chinese.
Objective. To investigate the roles of mouse erythroid differentiation and denucleation factor (MKI)DF), a novel factor cloned in our laboratory recently, in erylhroid terminal differentiation.Method. Mouse erythroleu...
In the present study, FBL3 murine erythroleukemia cells were transfected with human OSM(hOSM) gene by recombinant adenovirus, then the immunological properties of hOSM genetransfected FBL3 cells(FBL3OSM+) were investi...
Adenoviruses harboring E. coli. cytosine deaminase(CD) gene (Ad-CD) and murine granulocyte-macrophage colony stimulating factor (GM-CSF) gene(Ad-GM-CSF) were used for gene transfer in vivo.(C57BL/6 mice were inoculate...
Project supported by the National Natural Science Foundation of China.
A permanent lymphocyte cell line of a heterozygote with Yunnanese (Aγδβ)0-thalassemia deletion, associated with an increased production of Cry globin in adult, was founded using Epstein-Barr virus transformation. T...