funded by Project Management Unit,Banha University,Banha,Egypt
Methylprednisolone(MP) is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury(SCI). Vitamin C(VC) is a natural water-soluble antioxidant that exerts neuroprotective ...
supported by the National Natural Science Foundation of China,No.30960448;the Natural Science Foundation of Jiangxi Province,No.20142BAB205023;the Ph.D.Start-up Fund of Natural Science Foundation of Jiangxi Science&Technology Normal University in China,No.3000990122
Methylprednisolone is a commonly used drug for the treatment of spinal cord injury, but high doses of methylprednisolone can increase the incidence of infectious diseases. Methotrexate has anti-inflammatory activity a...
supported by the National Natural Science Foundation of China,No.81471854
Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury, and expression levels of specific proteins, including low-density lipoprotein receptor related protein-6...
Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-y in the spinal cord. Methy...
supported by the National Natural Science Foundation of China,No.81171799,81471854;the Science and Technology Research Project of Education Department of Liaoning Province of China,No.L2013333;the"College Students’Science and Technology Innovation Project"of Liaoning Medical University Principal Fund-Aohong Boze Fund of China,No.2014D08;the Liaoning Medical University Principal Fund-Aohong Boze Graduate Student Science Research Innovation Fund,No.AH2014017
Methylprednisolone markedly reduces autophagy and apoptosis after secondary spinal cord injury. Here, we investigated whether pretreatment of cells with methylprednisolone would protect neuron-like cells from subseque...
The present study was undertaken to examine the effects of methylprednisolone on the expression and activity of calpain in spinal cord tissue following spinal cord ischemia-reperfusion injury in rats. Adult male Sprag...
the Research Fund of First Affiliated Hospital,Xinjiang Medical University,China,No.2008-YFY-05;the Postgraduate Fund of the First Affiliated Hospital,Xinjiang Medical University,No.2010PGF01
High dose methylprednisolone intravenous injections are effective in treating acute spinal cord injury but can have severe side effects. In this study, we investigated intrathecal delivery of methylprednisolone for th...
BACKGROUND:Ginkgo biloba leaf extract exhibits neuroprotective effects in spinal cord injury. However, the mechanisms of action remain unclear. OBJECTIVE: To investigate inducible nitric oxide synthase (iNOS) and ...
the Natural Science Foundation of Hainan Province, No. 39914
BACKGROUND: The direct current electrical field can effectively promote the regeneration of the spinal cord; moreover, methylprednisolone (MP) can relieve secondary edema after spinal cord injury. Tetrandrine (Tet...
ThisworkwassupportedpartlybyagrantfromtheNaturalScienceResearchFoundationofJiangsuProvince ,China (No 990 14 5 )
Objective To investigate the effects of combination therapy with methylprednisolone (MP) and brain-derived neurotrophic factor (BDNF) on axonal remyelination and functional recovery after spinal cord injury in rats. M...