METHYLPREDNISOLONE

作品数:98被引量:353H指数:10
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相关领域:医药卫生更多>>
相关作者:胡宝华张祥宝史建刚贾连顺李家顺更多>>
相关机构:台湾大学宁波市第二医院第二军医大学解放军第98医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家科技支撑计划更多>>
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Does vitamin C have the ability to augment the therapeutic effect of bone marrow-derived mesenchymal stem cells on spinal cord injury?被引量:2
《Neural Regeneration Research》2017年第12期2050-2058,共9页Nesrine Salem Mohamed Y.Salem Mohammed M.Elmaghrabi Moataz A.Elawady Mona A.Elawady Dina Sabry Ashraf Shamaa Abdel-Haleem H.Elkasapy Noha Ibrhim Azza Elamir 
funded by Project Management Unit,Banha University,Banha,Egypt
Methylprednisolone(MP) is currently the only drug confirmed to exhibit a neuroprotective effect on acute spinal cord injury(SCI). Vitamin C(VC) is a natural water-soluble antioxidant that exerts neuroprotective ...
关键词:nerve regeneration spinal cord injury vitamin C METHYLPREDNISOLONE bone marrow mesenchymalstern cells locotmotor neural regeneration 
Methotrexate combined with methylprednisolone for the recovery of motor function and differential gene expression in rats with spinal cord injury被引量:6
《Neural Regeneration Research》2017年第9期1507-1518,共12页Jian-tao Liu Si Zhang Bing Gu Hua-nan Li Shuo-yu Wang Shui-yin Zhang 
supported by the National Natural Science Foundation of China,No.30960448;the Natural Science Foundation of Jiangxi Province,No.20142BAB205023;the Ph.D.Start-up Fund of Natural Science Foundation of Jiangxi Science&Technology Normal University in China,No.3000990122
Methylprednisolone is a commonly used drug for the treatment of spinal cord injury, but high doses of methylprednisolone can increase the incidence of infectious diseases. Methotrexate has anti-inflammatory activity a...
关键词:nerve regeneration spinal cord injury METHOTREXATE METHYLPREDNISOLONE GAIT gene expression profile inflammation oxidative stress apoptosis nerve repair Solexa gene sequencing secondary lesion neural regeneration 
Methylprednisolone promotes recovery of neurological function after spinal cord injury: association with Wnt/β-catenin signaling pathway activation被引量:12
《Neural Regeneration Research》2016年第11期1816-1823,共8页Gong-biao Lu Fu-wen Niu Ying-chun Zhang Lin DU Zhi-yuan Liang Yuan Gao Ting-zhen Yan Zhi-kui Nie Kai Gao 
supported by the National Natural Science Foundation of China,No.81471854
Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury, and expression levels of specific proteins, including low-density lipoprotein receptor related protein-6...
关键词:nerve regeneration spinal cord injury NEUROPROTECTION METHYLPREDNISOLONE apoptosis locomotor function caspase-3 caspase- 9 BAX Bcl-2 neural regeneration 
Combination of methylprednisolone and rosiglitazone promotes recovery of neurological function after spinal cord injury被引量:4
《Neural Regeneration Research》2016年第10期1678-1684,共7页Xi-gong Li Xiang-jin Lin Jun-hua Du San-zhong Xu Xian-feng Lou Zhong Chen 
Methylprednisolone exhibits anti-inflammatory antioxidant properties, and rosiglitazone acts as an anti-inflammatory and antioxidant by activating peroxisome proliferator-activated receptor-y in the spinal cord. Methy...
关键词:nerve regeneration spinal cord injury methylprednisotone ROSIGLITAZONE INFLAMMATION drug therapy anti-inflammatory agents functional recovery neural regeneration 
Methylprednisolone exerts neuroprotective effects by regulating autophagy and apoptosis被引量:2
《Neural Regeneration Research》2016年第5期823-828,共6页Wei Gao Shu-rui Chen Meng-yao Wu Kai Gao Yuan-long Li Hong-yu Wang Chen-yuan Li Hong Li 
supported by the National Natural Science Foundation of China,No.81171799,81471854;the Science and Technology Research Project of Education Department of Liaoning Province of China,No.L2013333;the"College Students’Science and Technology Innovation Project"of Liaoning Medical University Principal Fund-Aohong Boze Fund of China,No.2014D08;the Liaoning Medical University Principal Fund-Aohong Boze Graduate Student Science Research Innovation Fund,No.AH2014017
Methylprednisolone markedly reduces autophagy and apoptosis after secondary spinal cord injury. Here, we investigated whether pretreatment of cells with methylprednisolone would protect neuron-like cells from subseque...
关键词:nerve regeneration spinal cord injury METHYLPREDNISOLONE oxidative stress N2a cells AUTOPHAGY light chain 3B BECLIN-1 APOPTOSIS NEUROPROTECTION H2O2 neural regeneration 
Effects of Methylprednisolone on the Expression and Activity of Calpain Following Ischemia-Reperfusion Spinal Cord Injury in Rats
《Neuroscience & Medicine》2014年第1期23-31,共9页Zifeng Zhang Jinquan Xu Yushu Bai Tiesheng Hou 
The present study was undertaken to examine the effects of methylprednisolone on the expression and activity of calpain in spinal cord tissue following spinal cord ischemia-reperfusion injury in rats. Adult male Sprag...
关键词:METHYLPREDNISOLONE Spinal CORD INJURY ISCHEMIA-REPERFUSION INJURY CALPAIN 
Methylprednisolone intrathecal injections suppress neuronal apoptosis following acute spinal cord injury
《Neural Regeneration Research》2011年第17期1306-1312,共7页Xinghua Song Jianjun Zhang Liwen Ding Li Cao Xiaoxiong Xu Hao Wen 
the Research Fund of First Affiliated Hospital,Xinjiang Medical University,China,No.2008-YFY-05;the Postgraduate Fund of the First Affiliated Hospital,Xinjiang Medical University,No.2010PGF01
High dose methylprednisolone intravenous injections are effective in treating acute spinal cord injury but can have severe side effects. In this study, we investigated intrathecal delivery of methylprednisolone for th...
关键词:spinal cord injury APOPTOSIS interleukin-1 receptor antagonist CASPASE-3 METHYLPREDNISOLONE neural regeneration 
Ginkgo biloba leaf extract effects on inducible nitric oxide synthase, Bcl-2, and Bax expression in rat models of spinal cord injury被引量:1
《Neural Regeneration Research》2008年第8期875-880,共6页Jiejun Jiao Bin Du 
BACKGROUND:Ginkgo biloba leaf extract exhibits neuroprotective effects in spinal cord injury. However, the mechanisms of action remain unclear. OBJECTIVE: To investigate inducible nitric oxide synthase (iNOS) and ...
关键词:apoptosis BCL-2/BAX ginkgo biloba leaf extract inducible nitric oxide synthase METHYLPREDNISOLONE NEUROPROTECTION spinal cord injury 
Methylprednisolone and tetrandrine in combination with direct current electrical field for treating acute spinal cord injury被引量:1
《Neural Regeneration Research》2007年第1期27-32,共6页Ningjiang Shen Yutian Wang Ji Cai 
the Natural Science Foundation of Hainan Province, No. 39914
BACKGROUND: The direct current electrical field can effectively promote the regeneration of the spinal cord; moreover, methylprednisolone (MP) can relieve secondary edema after spinal cord injury. Tetrandrine (Tet...
关键词:spinal cord injury METHYLPREDNISOLONE electric stimulation 
Combined therapy of methylprednisolone and brain-derived neurotrophic factor promotes axonal regeneration and functional recovery after spinal cord injury in rats被引量:13
《Chinese Medical Journal》2003年第3期95-99,共5页李立新 徐启武 吴幼章 胡卫星 顾培元 傅震 
ThisworkwassupportedpartlybyagrantfromtheNaturalScienceResearchFoundationofJiangsuProvince ,China (No 990 14 5 )
Objective To investigate the effects of combination therapy with methylprednisolone (MP) and brain-derived neurotrophic factor (BDNF) on axonal remyelination and functional recovery after spinal cord injury in rats. M...
关键词:spinal cord injuries METHYLPREDNISOLONE brain-derived neurotrophic factor 
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