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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease
《Neural Regeneration Research》2025年第7期1981-1988,共8页Shan Ping Yu Emily Choi Michael QJiang Ling Wei 
supported by National Health Institute(NIH)grant NS099596(to LW and SPY),NS114221(to LW and SPY);Veterans Affair(VA)SPiRE grant RX003865(to SPY);supported by the O.Wayne Rollins Endowment Fund(to SPY);John E.Steinhaus Endowment Fund(to LW)。
Stroke and Alzheimer's disease are common neurological disorders and often occur in the same individuals.The comorbidity of the two neurological disorders represents a grave health threat to older populations.This rev...
关键词：Ca^(2+)hypothesis cognitive deficits HYPERACTIVITY late-onset Alzheimer's disease NEURODEGENERATION N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment 
Corrigendum:Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer’s disease
《Neural Regeneration Research》2024年第10期2211-2211,共1页
https://doi.org/10.4103/1673-5374.393108 In the article titled“Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer’s disease”,published on ...
关键词：INVOLVEMENT ALZHEIMER 
Sorl1 knockout inhibits expression of brain-derived neurotrophic factor:involvement in the development of late-onset Alzheimer's disease被引量：3
《Neural Regeneration Research》2024年第7期1602-1607,共6页Mingri Zhao Xun Chen Jiangfeng Liu Yanjin Feng Chen Wang Ting Xu Wanxi Liu Xionghao Liu Mujun Liu Deren Hou 
supported by the Community Development Office of Hunan Provincial Science and Technology Department;China,Nos.2020SK53613(to DH),21JJ31006(to DH);the Fundamental Research Funds of Central South University,Nos.CX20220375(to TX),2023zzts215(to MZ)。
Sortilin-related receptor 1(SORL1)is a critical gene associated with late-onset Alzheimer’s disease.SORL1 contributes to the development and progression of this neurodegenerative condition by affecting the transport ...
关键词：brain-derived neurotrophic factor late-onset Alzheimer’s disease N-methyl-D-aspartate receptor sortilin-related receptor 1 SYNAPSE 
Alzheimer’s disease:a tale of two diseases?被引量：2
《Neural Regeneration Research》2021年第10期1958-1964,共7页Eleonora Nardini Ryan Hogan Anthony Flamier Gilbert Bernier 
This work was supported by grants from the National Science and Engineering Research Council of Canada(NSERC)(to GB),Canadian Institutes of Health Research(CIHR)(to GB),Maisonneuve-Rosemont Hospital Foundation and Fondation de la Famille Pierre Theroux(to GB).RH is supported by a fellowship from the Maisonneuve-Rosemont Hospital Foundation.AF is supported by post-doctoral fellowship from the Jane Coffin Childs Fund.
Sporadic late-onset Alzheimer’s disease(SLOAD)and familial early-onset Alzheimer’s disease(FEOAD)associated with dominant mutations in APP,PSEN1 and PSEN2,are thought to represent a spectrum of the same disorder bas...
关键词：aging Alzheimer’s disease BMI1 epigenetics FAMILIAL LATE-ONSET SPORADIC 
Differences in clinical and genetic characteristics between early-and late-onset narcolepsy in a Han Chinese cohort
《Neural Regeneration Research》2020年第10期1887-1893,共7页Hui Ouyang Fang Han Ze-Chen Zhou Jun Zhang 
supported by the Research Project of Central Health Care Special Fund,China,No.W2017BJ52(to JZ)
Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared ...
关键词：case-control studies clinical features genetic association studies genetic load genetic loci genetic phenomena hypothalamic diseases precision medicine risk assessment single nucleotide polymorphism 
APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease被引量：4
《Neural Regeneration Research》2014年第6期653-660,共8页Qin Zhou Dantao Peng Xinrui Yuan Zeping Lv Shenghang Pang Wenyu Jiang Chuyu Yang Xiaohong Shi Guofang Pang Yige Yang Haiqun Xie Wandong Zhang Caiyou Hu Ze Yang 
supported by the National Natural Science Foundation of China,No.81370445,81061120527,81241082;Major Funding from Beijing Hospital,No.BJ-2010-30;Key Project of Clinical Disciplines at the Subordinate Hospital,Ministry of Health,No.10120101;National Department Public Benefit Research Foundation by the Ministry of Health,No.201302008;12th 5-year National Program from Ministry of Scientific Technology,No.2012BAI10B01;Science and Technology Development Foundation of Guangxi Zhuang Autonomous Region,No.1355005-62;Canadian Institute of Health Research(CIHR),No.109606
Current evidence shows that apolipoprotein E （APOE）, apolipoprotein CI （APOC1） and low density lipoprotein receptor-related protein （LRP） variations are related to late-onset Alzheimer＇s disease. However, it re...
关键词：nerve degeneration cognitive disorders DEMENTIA Alzheimer＇s disease polymorphism apolipoprotein E apolipoprotein CI low density lipoprotein receptor-related protein NSFC grant neural regeneration 
A non-invasive,rapid method to genotype late-onset Alzheimer's disease-related apolipoprotein E gene polymorphisms被引量：1
《Neural Regeneration Research》2014年第1期69-75,共7页Li Yi Ting Wu Wenyuan Luo Wen Zhou Jun Wu 
supported by two grants from Science,Industry,Trade and Information Technology Commission of Shenzhen Municipality in China,grant No.201002063,JC20110518075 7A
The apolipoprotein E gene ε4 allele is considered a negative factor for neural regeneration in late-onset Alzheimer＇s disease cases. The aim of this study was to establish a non-invasive, rapid method to genotype ap...
关键词：nerve regeneration NEURODEGENERATION late-onset Alzheimer＇s disease apolipoprotein Egene real-time PCR DNA sequencing risk factor ALLELE neural regeneration 
SLC26A4 gene polymorphism and late-onset Alzheimer’s disease in a Han Chinese population from Qingdao,China被引量：1
《Neural Regeneration Research》2013年第8期754-759,共6页Jifang Zhang Yantuan Li 
In a recent genome-wide association study, the SLC26A4 gene rs2072064 polymorphism was found to be associated with late-onset Alzheimer＇s disease in Caucasians. Here, we investigated this association in a large North...
关键词：neural regeneration neurodegenerative diseases late-onset Alzheimer＇s disease SLC26A4 rs2072064 POLYMORPHISM genetic association Han Chinese population apolipoprotein E NEUROREGENERATION 
Correlation between prion protein gene codon 129 polymorphism and late-onset Alzheimer's disease
《Neural Regeneration Research》2009年第6期468-473,共6页Hairong Qian Luning Wang Xiaokun Qi Jianwei Liu Jing Liu Ling Ye Hengge Xie WeiWang Feng Qiu 
the 973 Project of the National Ministry of Science and Technology,No. 2006cb500700
BACKGROUND： Studies addressing the correlation between prion protein gene codon 129 polymorphism, Alzheimer＇s disease, and cognitive disorders have mainly focused on Caucasians. However, prion protein gene codon 1...
关键词：Alzheimer＇s disease prion protein POLYMORPHISM 
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