UBIQUINONE

作品数：10被引量：13H指数：2
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相关作者：徐红张启元张汝波屈正旺张兴康更多>>
相关机构：中国科学院首都师范大学华东理工大学更多>>
相关期刊：《Science China Chemistry》《World Journal of Gastroenterology》《Journal of Pharmacy and Pharmacology》《The Innovation》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划泰国研究基金World Health Organization更多>>
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Erlotinib combination with a mitochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival被引量：2
《World Journal of Gastroenterology》2024年第7期714-726,共13页Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram Pui-Kei Wu Susan Tsai Jong-In Park 
Supported by NIH/National Cancer Institute Grant,No.R01CA138441 and No.R01CA269452;UW Madison Centene Pancreas Cancer Collaborative Award,No.21-8568.
BACKGROUND Pancreatic cancer is a leading cause of cancer-related deaths.Increased activity of the epidermal growth factor receptor(EGFR)is often observed in pancreatic cancer,and the small molecule EGFR inhibitor erl...
关键词：Pancreatic cancer ERLOTINIB Mitochondria-targeted ubiquinone Mitochondria Combination therapy 
CPEB1,a novel risk gene in recent-onset schizophrenia,contributes to mitochondrial complex I defect caused by a defective provirus ERVWE1被引量：2
《World Journal of Psychiatry》2021年第11期1075-1094,共20页Ya-Ru Xia Xiao-Cui Wei Wen-Shi Li Qiu-Jin Yan Xiu-Lin Wu Wei Yao Xu-Hang Li Fan Zhu 
Supported by the National Natural Science Foundation of China,No.81971943,No.81772196,No.31470264,No.81271820,No.30870789,and No.30300117;the Stanley Foundation of United States,No.06R-1366(for Zhu F);the Medical Science Advancement Program(Basic Medical Sciences)of Wuhan University,No.TFJC 2018002.
BACKGROUND Schizophrenia afflicts 1%of the world population.Clinical studies suggest that schizophrenia patients may have an imbalance of mitochondrial energy metabolism via inhibition of mitochondrial complex I activ...
关键词：ERVWE1 CPEB1 NADH dehydrogenase ubiquinone flavoprotein 2 complex I PSEUDOGENE 
Liposoluble quinone promotes the reduction of hydrophobic mineral and extracellular electron transfer of Shewanella oneidensis MR-1被引量：2
《The Innovation》2021年第2期130-136,共7页Xiaohan Lin Fan Yang Le-xing You Huan Wang Feng Zhao 
This study was supported by grants from the National Key R&D Program of China(2018YFC1800502);the National Natural Science Foundation of China(nos.42021005 and 22025603);the FJIRSM&IUE Joint Research Fund(RHZX-2018-006).
A large number of reaction systems are composed of hydrophobic interfaces and microorganisms in natural environment.However,it is not clear how microorganisms adjust their breathing patterns and respond to hydrophobic...
关键词：UBIQUINONE WETTABILITY HYDROPHOBIC Shewanella oneidensis RIBOFLAVIN extracellular electron transfer 
Protective Effect of Ubiquinone and Precursors of ItsSynthesis on Mitochondrial Respiratory Chain andActivity of Matrix Metalloproteinases in Animal Tissuesunder Effect of Doxorubicin
《Journal of Pharmacy and Pharmacology》2015年第3期116-127,共12页Anatoliy Burlaka Olena Kuchmenko Dmytro Petukhov Iryna Ganusevych Sergiy Lukin Evgeniya Lukyanchuk Evgen Sydoryk Georgiy Donchenko 
Mitochondrial dysfunction, oxidative stress, and their regulation are important fields of study in modem clinical research.Exogenous CoQ is an efficient therapeutic agent, yet its application has leads to continued su...
关键词：Ubiquinone  mitochondrion  matrix metalloproteinases  doxorubicin. 
HMG CoA reductase inhibition by Simvastatin gets rat <i>β</i>-Myosin heavy chain disappeared: A statin paradox
《Open Journal of Molecular and Integrative Physiology》2013年第1期1-5,共5页Laura Trapani Marco Segatto Adam Jozwiak Ewa Swiezewska Valentina Pallottini 
3-hydroxy-3methylglutaryl Coenzyme A reductase, the rate limiting enzyme of mevalonate pathway, generates, in addition to cholesterol, a range of products involved in several biological functions: oligoprenyl groups, ...
关键词：Heart MYOSIN Heavy Chains STATINS UBIQUINONE 
Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex Ⅱ via a water molecule mediated binding feature被引量：2
《Protein & Cell》2011年第7期531-542,共12页Qiangjun Zhou Yujia Zhai Jizhong Lou Man Liu Xiaoyun Pang Fei Sun 
supported by grants from the National Basic Research Program(973 Program)(Nos.2011CB910301,2011CB910900,and 2006CB806506);the National Natural Science Foundation of China(Grant No.31021062).
The mitochondrial respiratory complex Ⅱ or succinate:ubiquinone oxidoreductase(SQR)is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration.Five disinfectant compounds were investigated ...
关键词：mitochondrial respiratory complexⅡ THIABENDAZOLE PENTACHLOROPHENOL inhibition CRYSTALLOGRAPHY 
Putative metabolic roles of the mitochondria in asexual blood stages and gametocytes of Plasmodium falciparum被引量：4
《Asian Pacific Journal of Tropical Medicine》2008年第1期31-49,共19页Krungkrai J Kanchanaphum P Pongsabut S Krungkrai SR 
the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases(CHEMAL);the National Science and Technology Development Agency of Thailand (Career Development Award);the Thailand Research Fund(Basic Research)
Upon infection into human red cell,Plasmodium falciparum differentiates into asexual and sexual(gametocyte) stages.The mitochondrion is a tubular-cristate organelle,functionally and structurally different between the ...
关键词：malaria MITOCHONDRION metabolism electron transport system oxygen utilization pyrimidine BIOSYNTHESIS tricarboxylic acid cycle heme BIOSYNTHESIS UBIQUINONE BIOSYNTHESIS protein synthesis ANTIMALARIAL drug target 
Ubiquinone (Coenzyme Q) Biosynthesis in Chlamydophila pneumoniae AR39:Identification of the ubiD Gene
《Acta Biochimica et Biophysica Sinica》2006年第10期725-730,共6页Jun LIU Jian-Hua LIU 
Ubiquinone is an essential electron carrier in prokaryotes. Ubiquinone biosynthesis involves at least nine reactions in Escherichia coli. 3-octaprenyl-4-hydroxybenzoate decarboxylase （UbiD） is an important enzyme on...
关键词：UbiD UBIQUINONE BIOSYNTHESIS Chlamydophila pneumoniae 
Theoretical Studies on the Mechanism of the Proton-transfer-coupled Electron Transfer Reactions Between Menaquinone Q_A and Ubiquinone Q_B in the Bacterial Photosynthetic Reaction Center of Rhodopseudomona viridis被引量：1
《Acta Botanica Sinica》2002年第12期1409-1417,共9页马淑华 徐红 张汝波 屈正旺 张兴康 张启元 
国家自然科学重大基金 (3 9890 3 90 ) ;国家基础研究发展规划项目 (G19980 10 10 0 )~~
The mechanism of the proton_transfer_coupled electron transfer (PT_ET) reactions between the menaquinone Q A (MQ 1) and ubiquinone Q B (UQ 1) in the bacterial photosynthetic reaction center of Rhodopseudomona vi...
关键词：Rhodopseudomena viridis electron transfer proton transfer Q  A and Q  B DFT 
TWO-SITE PROPERTY OF THENOYLTRIFLUOROACETONE INHIBITING SUCCINATE-UBIQUINONE REDUCTASE
《Science China Chemistry》1992年第2期162-168,共7页徐建兴 TSOO E.KING 
This work was co-supported by Grants NIH GM-16767 of USA and the National Natural Science Foundation of China
It is proved by using the Dixon plot and the Lineweaver-Burk plot that thenoyltrifluoroacetone (TTFA) has two inhibitive sites affecting the reduction of ubiquinone catalyzed by succinate-ubiquinone reductase. The hig...
关键词：succinate-ubiquinone REDUCTASE inhibition TTFA. 
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