ANTITUMOR

作品数：469被引量：1197H指数：15
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相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>
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Peptide-based strategies for overcoming multidrug-resistance in cancer therapy
《Chinese Chemical Letters》2025年第1期110-118,共9页Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong Qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang Qin Xin Luan 
supported by the Science and Technology Innovation Program of Hunan Province(No.2022RC1168);National Natural Science Foundation of China(Nos.82322073,82173846,82304533);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009);Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302);China Postdoctoral Science Foundation(No.2021M702215);Oriental Scholars of Shanghai Universities(No.TP2022081);Jiangxi Province Thousand Talents Program(No.jxsq2023102168);Young Talent Lifting Project of China Association of Chinese Medicine(No.CACM-(2021-QNRC2-A08));Shanghai Rising-Star Program(No.22QA1409100);Shanghai Sailing Program(No.22YF1445000);2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800);Three-year Action Plan for Shanghai TCM Development and Inheritance Program(Nos.ZY(2021-2023)-0208,ZY(2021-2023)-0401);High level Key Discipline of National Administration of Traditional Chinese Medicine(No.71);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004);Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology。
Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade therapies.The demand for...
关键词：Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics IMMUNOTHERAPY Medicinal chemistry 
Application of magnetotactic bacteria as engineering microrobots:Higher delivery efficiency of antitumor medicine
《Chinese Chemical Letters》2024年第10期139-146,共8页Jing Zhang Charles Wang Yaoyao Zhang Haining Xia Yujuan Wang Kun Ma junfeng Wang 
supported by the National Natural Science Foundation of China(No.3190110313 to K.Ma);Special Foundation of President of the Chinese Academy of Sciences(No.YZJJ2022QN_(4)4);HFIPS Director’s Fund(Nos.E16CWK123X1;YZJJQY202201);the Heye Health Technology Chong Ming Project(No.HYCMP-2022012 to Y.Wang)。
For a significant duration,enhancing the efficacy of cancer therapy has remained a critical concern.Magnetotactic bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery system.MTB,clas...
关键词：Magnetotactic bacteria Engineering microrobot Tumor treatment Drug delivery BIOCONJUGATION 
Luminescence-activated Pt(Ⅳ)prodrug for in situ triggerable cancer therapy
《Chinese Chemical Letters》2024年第7期383-387,共5页Huijie An Chen Yang Zhihui Jiang Junjie Yuan Zhongming Qiu Longhao Chen Xin Chen Mutu Huang Linlang Huang Hongju Lin Biao Cheng Hongjiang Liu Zhiqiang Yu 
supported by the National Natural Science Foundation of China(Nos.32201171 and 82372115);the Science and Technology Program of Guangzhou(No.202102021266)。
Anticancer platinum prodrugs that can be controllably activated are highly desired for personalized precision medicine and patient compliance in cancer therapy.However,the clinical application of platinum(Ⅳ)prodrugs(...
关键词：Tumor microenvironment Endogenous luminescence Platinum(Ⅳ)prodrug Activation strategy ANTITUMOR BIOSAFETY 
Environmentally sensitive fluorescent probes with improved properties for detecting and imaging PDEδ in live cells and tumor slices被引量：1
《Chinese Chemical Letters》2023年第11期214-219,共6页Keliang Li Shanchao Wu Gaopan Dong Yu Li Wei Wang Guoqiang Dong Zhanying Hong Minyong Li Chunquan Sheng 
supported by the National Key Research and Development Program of China(No.2020YFA0509200 to C.Sheng);National Natural Science Foundation of China(Nos.81903436 to Y.Li,82204211 to W.Wang and 22077138 to S.Wu);Shanghai Rising-Star Program(No.22QA1411300 to S.Wu).
Kirsten rat sarcoma viral oncogene homolog(KRAS)-phosphodiesterase-delta(PDEδ)is a promising target for antitumor drug discovery.Herein,highly efficient and environmentally sensitive fluorescent probes of PDEδ(DS-Pr...
关键词：ANTITUMOR PDEδ Fluorescent probes Environmentally sensitive Binding affinity 
Nanovaccines for cancer immunotherapy:Current knowledge and future perspectives被引量：3
《Chinese Chemical Letters》2023年第8期57-68,共12页Yiming Wu Zhe Zhang Yuquan Wei Zhiyong Qian Xiawei Wei 
supported by the National Science Foundation for Excellent Young Scholars(No.32122052);National Natural Science Foundation Regional Innovation and Development(No.U19A2003).
Cancer immunotherapy harnesses the immune system to attack tumors and has received extensive attention in recent years.Cancer vaccines as an important branch of immunotherapy are designed for delivering tumor antigens...
关键词：Cancer immunotherapy Cancer vaccines NANOPARTICLES Antitumor immune response Clinical transformation 
Degradable nanocatalyst enables antitumor/antibacterial therapy and promotion of wound healing for diabetes via self-enhanced cascading reaction被引量：2
《Chinese Chemical Letters》2023年第7期155-161,共7页Xiang Wang Cheng Ding Ziwen Zhang Chunlin Li Dongmiao Cao Linjing Zhao Guoying Deng Yu Luo Chunping Yuan Jie Lu Xijian Liu 
supported by the Laboratory Animal Welfare and Ethics Committee of the Clinical Center of Shanghai First People's Hospital (No. 2020AWS0065);financially supported by the National Natural Science Foundation of China (Nos. 21978165, 92156020);Science and Technology Commission of Shanghai (No. 20DZ2255900);Class Ⅲ Peak Discipline of Shanghai—Materials Science and Engineering (High-Energy Beam Intelligent Processing and Green Manufacturing)。
Diabetic patients often have problems such as residual tumor and wound infection after tumor resection,causing severe clinical problems.It is urgent to develop effective therapies to reach oncotherapy/antiinfection/pr...
关键词：Self-cascade reaction Starvation therapy Chemodynamic therapy ANTITUMOR ANTIBACTERIAL Wound healing 
Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy被引量：1
《Chinese Chemical Letters》2022年第9期4339-4344,共6页Chunlei Wu Yanyan Li Zhehong Cheng Pengxin Wang Zhilong Ma Ke Liu Yulian Cheng Yimin Zhou Xian Lin Ximing Shao Yong Yang Hongchang Li Lijing Fang 
supported by the National Natural Science Foundation of China(Nos.21977111 and 22007096);the National Key Research and Development Program of China(No.2021YFA0910000);the Natural Science Foundation of Guangdong Province(Nos.2019A1515012073 and 2018B030308001);the Shenzhen Science and Technology Innovation Commission(No.JCYJ20210324120200001).
Riboflavin(RF,vitamin B2)is an essential vitamin and has been considered as a promising natural photosensitizer for photodynamic therapy(PDT).However,further exploration of RF in antitumor application was limited by i...
关键词：RIBOFLAVIN ANTITUMOR Photodynamic therapy Cell-penetrating peptides 
Short and simple peptide-based pH-sensitive hydrogel for antitumor drug delivery被引量：1
《Chinese Chemical Letters》2022年第4期1936-1940,共5页Jie Li Zhongshi Wang Han Han Zhonghua Xu Shasha Li Ying Zhu Yuejian Chen Liang Ge Yuan Zhang 
supported by the National Natural Science Foundation of China (Nos. 81572978 and 81760638);Special Science and Frontier Technology Research Project of Chongqing(No. cstc2016jcyj A0520);Innovative Technology in Military and Clinical Medicine (No. 2018JSLC0035);Natural Science Foundation of Xinjiang Province (No. 2017D01C200)。
Since self-assembled peptide hydrogels can solve the problems such as low solubility, poor selectivity and serious adverse effects of traditional chemotherapy drugs, they have been widely used as carrier materials for...
关键词：Peptide hydrogel pH Sensitivity ANTITUMOR Drug delivery Targeted therapy 
Design, synthesis and antitumor evaluations of nucleoside base hydroxamic acid derivatives as DNMT and HDAC dual inhibitors
《Chinese Chemical Letters》2021年第8期2479-2483,共5页Qinsheng Sun Qiuzi Dai Cunlong Zhang Yan Chen Lei Zhao Zigao Yuan Yuyang Jiang 
financial supports from China Postdoctoral Science Foundation (No.2018M631825);Shenzhen Development and Reform Committee (No.2019156);Shenzhen Science,Technology and Innovation Commission (No.JCYJ20180306174248782);Department of Science and Technology of Guangdong Province (No.2017B030314083);Shenzhen Bay Laboratory Open Funding (No.SZBL2019062801009)。
DNA methyl transferase(DNMT) and histone deacetylase(HDAC) are well recognized epigenetic targets for discovery of antitumor agents.In this study,we designed and synthesized a series of nucleoside base hydroxamic acid...
关键词：EPIGENETIC DNMT HDAC Multitarget Antitumor bioactivity 
Egg white as a natural and safe biomaterial for enhanced cancer therapy
《Chinese Chemical Letters》2021年第5期1737-1742,共6页Jun Huang Xinru You Peikun Xin Zhipeng Gu Chun Chen Jun Wu 
supported by National Science and Technology Major Project of the Ministry of Science and Technology of China (No.2018ZX10301402);International Cooperation and Exchange of the National Natural Science Foundation of China (No.51820105004);China Postdoctoral Science Foundation (No. 2019M663246);the Fundamental Research Funds for the Central Universities (Nos.191gzd35 and 20ykpy15);Guangdong Basic and Applied Basic Research Foundation (No.2019A1515110686);the Seventh Affiliated Hospital of Sun Yat-sen University (Shenzhen) Research Startup Fund (No.ZSQYRSFPD0015);Science and Technology Program of Guangzhou (Nos.201707010094 and 201704020095);Guangdong Innovative and Entrepreneurial Research Team Program (Nos.2016ZT06S252 and 2016ZT06S029);Science and Technology Planning Project of Shenzhen (No.JCYJ20170307141438157);Shenzhen Foundation of Science and Technology (No.JCYJ20170818103626421);National Natural Science Foundation of China (No.51973243)
The last few decades have witnessed the eme rgence of a very large variety of engineered nanomaterials.However,it is far from to meet the growing clinical demand.Actually,nature itself is an excellent na notechnologis...
关键词：Egg white Natural biomaterial NANOCARRIER Biosafe ANTITUMOR 
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