云南高校图书馆联盟文献共享服务平台- ANTITUMOR

ANTITUMOR: 作品数：470被引量：1206H指数：15; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：明艳林陈良华刘韶松齐宪荣李润涛更多>>; 相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>

Research Progress of Structure Based Antitumor Drug Design: 《Chinese Journal of Structural Chemistry》2020年第12期2085-2090,2053,共7页ZHANG Lei CHEN Zhuo; supported by the National Natural Science Foundation of China(21877113,81572944,31300650);Natural Science Foundation of Fujian Province(2020I0036,2019Y9062,2013N0039);the CAS/SAFEA International Partnership Program for Creative Research Teams(30973567);the High-Level Entrepreneurship and Innovation Talents Projects in Fujian Province(2018-8-1)。; At present,the development of antineoplastic drugs has been highly concerned.Many strategies have been developed to explore the safety and effectiveness of antitumor drugs.In recent years,the progress of structural an...; 关键词：STRUCTURE drug design ANTITUMOR

Diorganotin Complexes of N-[4-(Diethylamino)salicylidene]-(L)-tryptophane: Syntheses, Structures and Properties被引量：1: 《Chinese Journal of Structural Chemistry》2019年第11期1977-1985,共9页TIAN Lai-Jin CHEN Le-Xing AN Wu-Gai LIU Xi-Cheng; Financially supported by the Natural Science Foundation of Shandong Province(ZR2013BM007);the National Natural Science Foundation of China(21702119); Four chiral diorganotin complexes of N-[4-(diethylamino)salicylidene]-(L)-tryptophane,R2Sn[4-(Et2N)-2-OC6H3CH=NCH(CH2Ind)COO](Ind=3-indolyl;R=Me(1);Et,(2);n-Bu(3);Cy(cyclohexyl)(4)),have been synthesized and character...; 关键词：ORGANOTIN complex SCHIFF base CRYSTAL structure ANTITUMOR activity FLUORESCENCE

Syntheses, Crystal Structures and Biological Activities of Three New Benzoxazole Derivatives Containing Pyridyl Moiety: 《Chinese Journal of Structural Chemistry》2019年第11期1902-1908,共7页XING Guo-Xiang TAO Jia-Yu WANG Xiao-Yu LI Zheng-Zheng FANG Xian-Ying GUO Ying-Xin FU Bo XU Hai-Jun; Supported by the National Key R&D Program of China(2016YFD0600804);Natural Scientific Foundation of Jiangsu Province(No.BK20160922);National Natural Scientific Foundation of China(No.21606133);the Open Fund of Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals(JSBGFC12002);SPITP(201710298006Z); Three novel benzoxazole derivatives based on the pyridyl group were designed and synthesized from 2-methylbenzoxazole and three different types of pyridylaldehyde.Their structures were confirmed by HRMS,1H NMR,13C NMR...; 关键词：BENZOXAZOLE derivatives PYRIDINE synthesis crystal structure ANTITUMOR activity

Antitumor and Antioxidant Activities of the New Anthraquinone Derivatives: Synthesis, DPPH, ABTS, Biological and DFT Investigations被引量：2: 《Chinese Journal of Structural Chemistry》2019年第10期1673-1690,1610,共19页SYAMAK Shahab MASOOME Sheikhi RADWAN Alnajjar LIUDMILA Filippovich EVGENJ Dikusar; supported by the National Academy of Sciences of Belarus; In the given research,for the first time the molecular structures of four new anthraquinone derivatives have been predicted and investigated by using Density Functional Theory(DFT/M052X/MidiX)in water.After quantum-ch...; 关键词：ANTHRAQUINONE ANTIOXIDANT ANTITUMOR RADICAL

Synthesis, Crystal Structure and Antitumor Activities of N-(2-(2-hydroxy-2-phenylacetyl)phenyl)cinnamamide: 《Chinese Journal of Structural Chemistry》2019年第10期1701-1706,1610,共7页王芳周学浩肖新生贾国凯; supported by the construct program of applied characteristic discipline in Hunan University of Science and Engineering,Research Learning and Innovative Experimental Program for College Students of Hunan University of Science and Engineering(No.[2018]32-51);the opening project of key laboratory of comprehensive utilization of advantage plants resources in Hunan south,Hunan university of science and engineering(No.XNZW17C04,XNZW17C05);the Planned Science and Technology Project of Hunan Yongzhou,China(No.2018ZD15); The title compound N-(2-(2-hydroxy-2-phenylacetyl)phenyl)cinnamamide(C23H19NO3,Mr=357.39)has been synthesized with 2-iodoaniline and ethynylbenzene as starting materials,and its crystal structure was determined by ^1H...; 关键词：SYNTHESIS CRYSTAL structure ANTITUMOR activity

Synthesis, Structure and Biological Activity of 2-[2-(4-Fluorobenzylidene)hydrazinyl]-4-(1-methyl-1H-indol-3-yl)thieno[3,2-d]pyrimidine被引量：3: 《Chinese Journal of Structural Chemistry》2019年第9期1530-1536,共7页SHI Jian-Tao GONG Yi-Lin LI Jun WANG Yang CHEN Ye DING Shi LIU Ju; Supported by the projects of Shenyang Science&Technology(18-013-0-03);the Youth National Natural Science Foundation of China(21807055); The title compound 2-[2-(4-fluorobenzylidene)hydrazinyl]-4-(1-methyl-1 H-indol-3-yl)thieno[3,2-d] pyrimidine(8) was synthesized by the condensation of 4-fluorobenzaldehyde(7) with 2-hydrazinyl-4-(1-methyl-1 H-indol-3-...; 关键词：thieno[3 2-d] PYRIMIDINE SYNTHESIS X-ray DIFFRACTION ANTITUMOR activity

Synthesis, Crystal Structure and Antitumor Activity of 4-(5-(2,6-Difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine: 《Chinese Journal of Structural Chemistry》2019年第8期1344-1348,共5页SONG Xin-Jian LI Chen-Chen WANG Xu-Mei SUN Qi YANG Ping; supported by the National Natural Science Foundation of China(No.21262012); The title compound 4-(5-(2,6-difluorophenyl)-1,3,4-oxadiazol-2-ylthio)-2-(trifluoromethyl)thieno[2,3-d]pyrimidine(C15H5F5N4OS2, Mr = 416.35) was designed and synthesized as antitumor agent, and its structure was deter...; 关键词：thieno[2 3-d]pyrimidine 1 3 4-OXADIAZOLE FLUORINATED compound crystal structure ANTITUMOR activity

Synthesis, Crystal Structure and Antitumor Activity of a Na(Ⅰ) Coordination Polymer Based on 2-Propyl-4,5-imidazoledicarboxylic Acid and 1,10-Phenanthroline Ligands被引量：1: 《Chinese Journal of Structural Chemistry》2019年第7期1079-1085,共7页TAI Xi-Shi ZHOU Xiao-Jing LIU Li-Li; supported by the National Natural Science Foundation of China(No.21171132);the Project of Shandong Province Higher Educational Science and Technology Program(J14LC01);Science Foundation of Weifang; A new Na(I) coordination polymer,[Na2(Hpimdc)(H2 pimdc)(phen)2]n(1), has been synthesized by the reaction of NaOH with 2-propyl-4,5-imidazoledicarboxylic acid(H3 pimdc)and 1,10-phenanthroline(phen). The Na(I) coordina...; 关键词：2-propyl-4 5-imidazoledicarboxylic acid Na(Ⅰ) coordination polymer SYNTHESIS crystal structure ANTITUMOR activity

Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas: 《Chinese Journal of Structural Chemistry》2019年第7期1086-1092,共7页SONG Xin-Jian WANG Xu-Mei SUN Qi HUANG Sheng-Tian WANG Yan; supported by the National Natural Science Foundation of China(No.21262012);the Natural Science Foundation of Hubei Province(No.2016CFB400); N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas 4 a～4 i were designed and synthesized as antitumor agents, and their structures were characterized by IR, 1 H NMR, 13 C NMR,MS and elemental analysis. The single ...; 关键词：1 3 4-THIADIAZOLE UREA crystal structure ANTITUMOR activity

Structural Modification for Antitumor Nitrogenous Steroids被引量：2: 《Chinese Journal of Structural Chemistry》2017年第12期2007-2019,共13页谢田鹏杨康张立志陈德胜邹坤黄年玉; Financial support from the National Natural Science Foundation of China(No.21272136);Youth Talent Development Foundation of China Three Gorges University; Natural steroids have been showing notable cytotoxic activities, which are quite interesting lead compounds for the development of anticancer drug including estramustine and prednimustine. Considering that these semi-...; 关键词：STEROIDS structural modification N-hetercycles ANTITUMOR structure-activity relationship

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