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ANTITUMOR: 作品数：470被引量：1206H指数：15; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：明艳林陈良华刘韶松齐宪荣李润涛更多>>; 相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>

Optical evodiamine derivatives:Asymmetric synthesis and antitumor activity被引量：2: 《Chinese Chemical Letters》2015年第3期267-271,共5页Zhen-Gang Li Guo-Qiang Dong Sheng-Zheng Wang Zhen-Yuan Miao Jian-Zhong Yao Wan-Nian Zhang Chun-Quan Sheng; supported by National Natural Science Foundation of China (Nos.81222044,81373278);Key Project of Science and Technology of Shanghai (Nos.11431920402,14YF1405400); Evodiamine and its derivatives have an asymmetric center at the C13 b position.Herein,isomers of evodiamine derivatives 2 and 3 were obtained by straightforward asymmetric total synthesis.Their inhibitory activities t...; 关键词：isomers asymmetric antitumor clarified toward hydrogenation hexane potent relaxation dissolved

Cyathula prostrata:A potent source of anticancer agent against daltons ascites in Swiss albino mice: 《Asian Pacific Journal of Tropical Medicine》2013年第10期776-779,共4页Priya K Krishnakumari S Vijayakumar M; Objective:To evaluate the anticancer activity of the methanolic extract of Cyathula prostrata in Ehrlich ascites carcinoma(EAC)-bearing mice with methotrexate as positive control in the advanced stage of tumorigenesis...; 关键词：ANTITUMOR Cyathula prostrata MTT Cancer Ehrlich ASCITES CARCINOMA

Celastrus Orbiculatus Extract Inhibits Tumor Angiogenesis by Targeting Vascular Endothelial Growth Factor Signaling Pathway and Shows Potent Antitumor Activity in Hepatocarcinomas in Vitro and in Vivo被引量：28: 《Chinese Journal of Integrative Medicine》2012年第10期752-760,共9页钱亚云张华侯莹员林李国青郭试瑜 Hisamits Tadashi 刘延庆; Supported by Plans of Colleges and Universities in Jiangsu Province to Postgraduate Research and Innovation(No.CX09B-321Z);State Administration of Traditional Chinese Medicine of People's Republic of China(No.04-05ZP35); Objective： Ce/astrus orbicu/atus Thunb. has been used for thousands of years in China as a remedy against cancer and inflammatory diseases. This study aims to investigate whether C. orbiculatus extract （COE） could ...; 关键词：ANTITUMOR Celastrus orbiculatus Thunb. ANGIOGENESIS vascular endothelial growth factor

Synthesis and Screening of New 5-Substituted-1,3,4-oxadiazole-2-thioglycosides as Potent Anticancer Agents: 《Pharmacology & Pharmacy》2012年第2期254-261,共8页Mamdouh A .Z. Abu-Zaied Galal A. M. Nawwar Randa H. Swellem Shahinaz H. El-Sayed; A series of newly 1,3,4-oxadiazole-2-thioglycoside derivatives were synthesized. The key step of this protocol is the coupling between 5-herteroaryl-1,3,4-oxadiazole-2-thione and activated sugars (cyclic or acyclic su...; 关键词：1 3 4-Oxadiazoles THIOGLYCOSIDES ACYCLIC Sugars ANTITUMOR

Grifolin,a potent antitumor natural product,upregulates death-associated protein kinase 1(DAPK1)via p53 in nasopharyngeal carcinoma cells被引量：1: 《中国病理生理杂志》2010年第A10期2006-2006,共1页LUO Xiang-jian1,LI Li-li1,DENG Qi-pan1,YU Xin-fang1,LUO Fei-jun1,YANG Li-fang1,XIAO Lan-bo1,CHEN Xiao-yan1,YE Mao1,LIU Ji-kai2,CAO Ya1(1Cancer Research Institute,Xiangya School of Medicine,Central South University,Changsha 410078,China 2Department of Phytochemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China); Grifolin,a secondary metabolite isolated from the fresh fruiting bodies of mushroom Albatrellus confluens,inhibits the growth of some cancer cell lines in vitro by induction of apoptosis in the previous studies of our...; 关键词：NASOPHARYNGEAL POTENT understood ANTITUMOR METABOLITE profiling MUSHROOM induction targeting fresh

Design and synthesis of L-5'-noraristeromycin analogues as potent antitumor agents被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2009年第4期313-319,共7页黄民俊杨振军张亮仁张礼和; National Natural Science Foundation of China(Grant No.20672010); Nucleoside analogues show a variety of biological activities. To prepare new purine nucleoside analogues that could inhibit the proliferation of tumor cells and resist enzyrne hydrolysis, we designed and synthesized 1...; 关键词：Carbocyclic nucleoside L-Nucleoside analogue ANTITUMOR

GA3, a new gambogic acid derivative, exhibits potent antitumor activities in vitro via apoptosis-involved mechanisms被引量：4: 《Acta Pharmacologica Sinica》2009年第3期346-354,共9页Hua XIE Yu-xin QIN Yun-long ZHOU Lin-jiang TONG Li-ping LIN Mei-yu GENG Wen-hu DUAN Jian DING; Acknowledgement This work was financially supported by the National Natural Science Foundation of China （No 30721005）. Hua XIE especially appreciated the support from a Shanghai Postdoctoral Grant （No 05R214157）.; Aim： Gambogic acid （GA） is the major active ingredient of gamboge, which is secreted from a Chinese traditional medicine, Garcinia hanburyi, which possesses potent antitumor activity. GA3, a new GA derivative, has ...; 关键词：gambogic acid GA3 ANTITUMOR APOPTOSIS CASPASE Bcl-2 cytochrome c

Synthesis of the (3R, 9S, 10S)-Diastereoisomer of Panaxytriol,a Potent Antitumor Polyacetylene from Panax ginseng被引量：1: 《Chinese Chemical Letters》1999年第3期201-204,共4页Wei LU Guang Rong ZHENG Jing Shan SHEN Jun Chao CAI(Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 200031); (3R, 9S, 10S)-Heptadec-1-ene-4,6-diyne-3, 9, 10-triol 2, a diastereoisomer of panaxytriol 1 was synthesized using L-(+)-diethyl tartrate 5 as a chiral template, through the Cadiot-Chodkiczwicz coupling of the terminal...; 关键词：DIASTEREOISOMER panaxytriol Cadiot-Chodkiczwicz coupling

POTENT INHIBITORY EFFECTS OF TUBEIMOSIDE 1 ISOLATED FROM THE BULB OF Bolbostemma paniculatum (MAXIM)FRANQUET ON INFLAMMATORY EAR OEDEMA AND TUMOR PROMOTION IN MICE被引量：1: 《Chinese Science Bulletin》1992年第7期602-606,共5页马润娣于立坚王永清 HOYOKU NISHINO JUNKO TAKAYASU; The research work was partly carried out in the Department of Biochemistry Kyoto Prefectural University of Medicine Japan; Numerous attempts have been made to select compounds that might reduce the incidence of cancer. Previously we have found out that several kinds of natural and; 关键词：TUBEIMOSIDE 1 anti-inflammatory activity ANTITUMOR promoting action.

ISOLATION AND CHARACTERIZATION OF MAYTANSINE AND MAYTANPRINE, TWO ANTICANCER AGENTS FROM MAYTENUS HOOKERI LOES被引量：2: 《Chinese Science Bulletin》1980年第7期612-615,共4页周韵丽黄丽瑛周倩如蒋初祥贺贤国李朝明王春李秉钧; Maytansine （I） (C34H46CIN3O10) is a novel type of ansa macrolide with potent antitumor activity. It was isolated by Kupchan et al. with great efforts from several Maytenus species （0.2 p.p.m.—1.5 p.p.m, dried plan...; 关键词：dosage attracting DRIED FOLDS POTENT ANTICANCER dissolved ANTITUMOR body showing

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