The project supported by National Natural Science Foundation of China(81301908);the Science and Technology Commission of Shanghai Municipality(15140904700,13ZR1412600 and 14DZ2270100)
OBJECTIVE Cytochrome P450(CYP)2J2 is highly expressed in many kinds of human tumors and promotes tumor cell growth via regulating the metabolism of arachidonic acids.The purposes of this study were toidentify the new ...
National High Technology Research and Development Program of China(863 Program)(2014AA022208);National Natural Science Foundation of China(31170131 and 31070312);Jiangsu Qinglan Project
Objective To isolate and identify the bioactive phytochemicals from the leaves of Camellia nitidissima. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, MCI gel colu...
the financial supports from the Natural Science Foundation of China(No.21101069)
Five organotin complexes of terpyridine derivatives were synthesized and characterized. The mononuclear Sn(IV) complexes were six-coordinated adopting a distorted octahedral coordination geometry. A brief outline of...
Supported by the National Natural Science Foundation of China(No.30360119)
A series of 2-[1-(2-formylamido-3-phenylpropionyloxy)alkyl]-1,4-dihydroxy-9,10-anthraquinone(2FPADHAQ) derivatives was designed and synthesized.Their antitumor activities were tested against L1210 tumor cells and ...
supported by Doctoral Innovation Research Assistance Program of the Science and Technology Review (kjdb200902-11)
Two novel rare earth substituted phosphotungstates containing 5-fluorouracil,K 9(C 4 H 4 FN 2 O 2) 2 Nd(PW 11 O 39) 2 ·25H 2 O(FNdPW) and K 9(C 4 H 4 FN 2 O 2) 2 Ce(PW 11 O 39) 2 ·23H 2 O(FCePW),were syn...
Objective:To evaluate the antitumor,cytotoxic and antioxidant activities of methanolic leaf extract of Indigofera cassioides(MEIC) against transplantable tumors and human cancer cell lines.Methods:MEIC was investigate...
supported by the National Natural Science Foundation of China(No.30873363);the Great Program of Science Foundation of Tianjin(No.09ZCKFNC01200);Program of Science Foundation of Tianjin (No.08JCYBJC070000).
In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as poten...
The characteristics of rhuIL-4 induced cytotoxicity was detected in vitro by using  ̄(51)Cr release assay and the anti-tumor activity of rhuIL-4 induced killer cell was evaluated in vivo by using a human tumor model i...
We have studied the cytotoxicity of three chemically diverse antitumor agents, i.e. camptothecin (CPT), lycobetaine (LBT) and oxalysine (OLS). CPT mainly acted on tumor cells in S phase by pronounced inhibition of DNA...