ANTITUMOR

作品数:470被引量:1206H指数:15
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相关领域:医药卫生生物学更多>>
相关作者:明艳林陈良华刘韶松齐宪荣李润涛更多>>
相关机构:北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划北京市自然科学基金更多>>
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Inhibitory effect of plumbagin,a potential anticancer natural compound,on cytochrome P450 2J2 in humans
《中国药理学与毒理学杂志》2016年第10期1044-1044,共1页LU Jian LIU Dao-zhi ZHOU Xiao-jing CHEN Ang LIU Ming-yao WANG Xin 
The project supported by National Natural Science Foundation of China(81301908);the Science and Technology Commission of Shanghai Municipality(15140904700,13ZR1412600 and 14DZ2270100)
OBJECTIVE Cytochrome P450(CYP)2J2 is highly expressed in many kinds of human tumors and promotes tumor cell growth via regulating the metabolism of arachidonic acids.The purposes of this study were toidentify the new ...
关键词:PLUMBAGIN astemizole CYP2J2 ANTITUMOR LC-MS/MS CYTOTOXICITY 
Chemical Constituents from Leaves of Camellia nitidissima and Their Potential Cytotoxicity on SGC7901 Cells被引量:25
《Chinese Herbal Medicines》2016年第1期80-84,共5页Jing Qi Ruo-fu Shi Jian-ming Yu Yi Li Sheng-tao Yuan Ji-zhu Yang Jiang-miao Hu Ai-qun Jia 
National High Technology Research and Development Program of China(863 Program)(2014AA022208);National Natural Science Foundation of China(31170131 and 31070312);Jiangsu Qinglan Project
Objective To isolate and identify the bioactive phytochemicals from the leaves of Camellia nitidissima. Methods The chemical constituents were isolated and purified by repeated silica gel, Sephadex LH-20, MCI gel colu...
关键词:ANTITUMOR Camellia nitidissima C-27 steroidal saponins FLAVONOIDS quorum sensinginhibitors SGC7901 triterpenes 
Synthesis,characterization and cytotoxicity of fluorescent organotin complexes of terpyridine derivatives被引量:1
《Chinese Chemical Letters》2014年第4期586-588,共3页Peng-Fei Shi Qin Jiang Hai-Chao Duan Da-Qi Wang 
the financial supports from the Natural Science Foundation of China(No.21101069)
Five organotin complexes of terpyridine derivatives were synthesized and characterized. The mononuclear Sn(IV) complexes were six-coordinated adopting a distorted octahedral coordination geometry. A brief outline of...
关键词:Organotin Terpyridine Antitumor 
Synthesis and Antitumor Activity of 2-[1-(2-Formylamido-3-phenylpropionyloxy)alkyl]-1,4dihydroxy-9,10-anthraquinone Derivatives
《Chemical Research in Chinese Universities》2012年第6期971-975,共5页J1N Li-li JIN Guang-zhu 
Supported by the National Natural Science Foundation of China(No.30360119)
A series of 2-[1-(2-formylamido-3-phenylpropionyloxy)alkyl]-1,4-dihydroxy-9,10-anthraquinone(2FPADHAQ) derivatives was designed and synthesized.Their antitumor activities were tested against L1210 tumor cells and ...
关键词:ANTHRAQUINONE ANTITUMOR CYTOTOXICITY PHENYLALANINE 
Synthesis,characterization and antitumor activity of rare earth(Y,La) substituted phosphotungstates containing 5-fluorouracil被引量:5
《Journal of Rare Earths》2012年第6期604-608,共5页刘霞 甘强 冯长根 
Project supported by Institution of Chemical Materials,China Academy of Engineering Physics
Two rare earth substituted Keggin-type phosphomngstates containing 5-fluorouracil, K10C4H4FN2O2Y(PW11O39)2· 10H2O (FYPW) and Kg(C4H4FN2O2)2La(PWl1O39)2· 18H2O (FLaPW) were synthesized in aqueous solution, ...
关键词:phosphotungstates 5-flurouracil rare earth CYTOTOXICITY ANTITUMOR HELA HEPG-2 
Synthesis and antitumor activities of rare earth substituted phosphotungstates containing 5-fluorouracil被引量:6
《Journal of Rare Earths》2012年第5期467-472,共6页冯长根 甘强 刘霞 何洪优 
supported by Doctoral Innovation Research Assistance Program of the Science and Technology Review (kjdb200902-11)
Two novel rare earth substituted phosphotungstates containing 5-fluorouracil,K 9(C 4 H 4 FN 2 O 2) 2 Nd(PW 11 O 39) 2 ·25H 2 O(FNdPW) and K 9(C 4 H 4 FN 2 O 2) 2 Ce(PW 11 O 39) 2 ·23H 2 O(FCePW),were syn...
关键词:phosphotungstates 5-fluorouracil rare earth HeLa HepG-2 antitumor cytotoxicity 
In vitro and in vivo anticancer activity of Indigofera cassioides Rottl.Ex. DC.被引量:6
《Asian Pacific Journal of Tropical Medicine》2011年第5期379-385,共7页Raju Senthil Kumar Balasubramanian Rajkapoor Perumal Perumal 
Objective:To evaluate the antitumor,cytotoxic and antioxidant activities of methanolic leaf extract of Indigofera cassioides(MEIC) against transplantable tumors and human cancer cell lines.Methods:MEIC was investigate...
关键词:INDIGOFERA cassioides CYTOTOXICITY ANTITUMOR ANTIOXIDANT Mean survival time HEMATOLOGICAL parameters Solid tumor volume 
Synthesis and cytotoxicity of novel podophyllotoxin derivatives被引量:3
《Chinese Chemical Letters》2009年第12期1431-1434,共4页Yi Zheng YOU Guang Sun Yuan Zhang Jing Jing Lv Wen Chao Bi Yuan Wei Ma Hong Chen 
supported by the National Natural Science Foundation of China(No.30873363);the Great Program of Science Foundation of Tianjin(No.09ZCKFNC01200);Program of Science Foundation of Tianjin (No.08JCYBJC070000).
In order to find novel synthetic antitumor agents with superior cytotoxicity and overcoming multidrug resistance, a novel series of 4β-N-substituted podophyllotoxin derivatives were synthesized and evaluated as poten...
关键词:Podophyllotoxin derivatives CHEMOSYNTHESIS ANTITUMOR Multidrug resistance 
EVALUATION OF THE ANTITUMOR ACTIVITY OF HUMAN IL-4 BY IN VITRO AND IN VIVO ASSAYS被引量:1
《Chinese Medical Sciences Journal》1994年第4期248-254,共7页王彤钢 陈慰峰 
The characteristics of rhuIL-4 induced cytotoxicity was detected in vitro by using  ̄(51)Cr release assay and the anti-tumor activity of rhuIL-4 induced killer cell was evaluated in vivo by using a human tumor model i...
关键词:IL-4 CTL cytotoxicity 
STUDIES ON CYTOTOXICITY AND INDUCTION OF SISTER CHROMATID EXCHANGES IN V79 CELLS WITH THREE ANTITUMOR AGENTS
《Chinese Science Bulletin》1984年第9期1268-1271,共4页王心伟 乐秀芳 韩家娴 吴富根 沈祖铭 胥彬 黄振球 
We have studied the cytotoxicity of three chemically diverse antitumor agents, i.e. camptothecin (CPT), lycobetaine (LBT) and oxalysine (OLS). CPT mainly acted on tumor cells in S phase by pronounced inhibition of DNA...
关键词:chemically CAMPTOTHECIN diverse ANTITUMOR acted CYTOTOXICITY dissolved inhibited UNTREATED DILUTED 
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