The authors are grateful for financial support from the Beijing Natural Science Foundation(No.JQ18024);the National Natural Science Foundation of China(Nos.21822701,91953111,21672012);the Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910001001);State Key Laboratory of Natural and Biomimetic Drugs.
An efficient method for the activation of C-terminal 4-mecaptoproline-or penicillamine-containing peptide hydrazides in ligation re-actions is reported herein.The corresp on ding peptide hydrazides can be readily prep...
Financial support for this work was gratefully received from the National Natural Science Foundation of China(Nos.22077080,21907064 and 91753102);the Interdisciplinary Program of Shanghai Jiao Tong University(No.YG2020YQ14).
Main observation and conclusion Selenoesters are useful substitutes for traditional thioesters in protein ligation chemistry due to their high reactivity in the trans-thio/selenoesterification reaction.However,existin...
Fund of Luzhou Government and Southwest Medical University(Nos.2019LZXNYDJ28,2018LZXNYD-ZK33,2018LZXNYD-ZK39);the Open Project of Central Nervous System Drug Key Laboratory of Sichuan Province(No.200023-01SZ);the research fund of Southwest Medical University(Nos.2017-ZRZD-020 and 2017-ZRQN-031).
Main observation and conclusion Alkoxy radical-mediated carbon-carbon bond cleavages have emerged as a powerful strategy to complement traditional ionic-type transformations.However,carbon-carbon cleavage reaction tri...
A novel sulfur-promoted cyclization of hydrazides and isonitriles to produce 1,3,4-oxadiazole has been devel- oped. The method is operationally simple and compatible with a wide scope of substrates and various 2-amino...
An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed o...
A novel and efficient approach to sulfonamides has been developed. Using TBHP as the oxidant and NH4I (20 mol%) as the catalyst, arylsulfonyl hydrazides reacted with amines to provide sulfonamides in moderate to goo...